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HMGCR

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GENERAL INFORMATION

Gene name

 HMGCR

Gene description

 3-hydroxy-3-methylglutaryl-CoA reductase

Protein class

 Enzymes
FDA approved drug targets
Plasma proteins
Predicted intracellular proteins
Predicted membrane proteins
Transporters

Predicted localization

 Intracellular,Membrane

Number of transcripts

 7
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 HMGCR

Synonyms

Description

 3-hydroxy-3-methylglutaryl-CoA reductase (HGNC Symbol)

Entrez gene summary

 HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]

Chromosome

 5

Cytoband

 q13.3

Chromosome location (bp)

 75336329 - 75362104

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000113161 (version 83.38)

Entrez gene

 3156

UniProt

 P04035 (UniProt - Evidence at protein level)

neXtProt

 NX_P04035

Antibodypedia

 HMGCR antibodies

PROTEIN BROWSER
HMGCR-001
HMGCR-002
HMGCR-004
HMGCR-005
HMGCR-006
HMGCR-009
HMGCR-010

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
HMGCR-001
ENSP00000287936
ENST00000287936
P04035 [Direct mapping]
3-hydroxy-3-methylglutaryl-coenzyme A reductase
A0A024RAP2 [Target identity:100%; Query identity:100%]
3-hydroxy-3-methylglutaryl coenzyme A reductase
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   8TM proteins predicted by MDM
Plasma proteins
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004420 [hydroxymethylglutaryl-CoA reductase (NADPH) activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005778 [peroxisomal membrane]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006695 [cholesterol biosynthetic process]
GO:0006743 [ubiquinone metabolic process]
GO:0007568 [aging]
GO:0007584 [response to nutrient]
GO:0008284 [positive regulation of cell proliferation]
GO:0008299 [isoprenoid biosynthetic process]
GO:0008542 [visual learning]
GO:0010664 [negative regulation of striated muscle cell apoptotic process]
GO:0010666 [positive regulation of cardiac muscle cell apoptotic process]
GO:0015936 [coenzyme A metabolic process]
GO:0016021 [integral component of membrane]
GO:0016616 [oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor]
GO:0032874 [positive regulation of stress-activated MAPK cascade]
GO:0042282 [hydroxymethylglutaryl-CoA reductase activity]
GO:0042803 [protein homodimerization activity]
GO:0043066 [negative regulation of apoptotic process]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043407 [negative regulation of MAP kinase activity]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0045445 [myoblast differentiation]
GO:0045471 [response to ethanol]
GO:0045908 [negative regulation of vasodilation]
GO:0048643 [positive regulation of skeletal muscle tissue development]
GO:0048661 [positive regulation of smooth muscle cell proliferation]
GO:0050661 [NADP binding]
GO:0050662 [coenzyme binding]
GO:0051262 [protein tetramerization]
GO:0051721 [protein phosphatase 2A binding]
GO:0055114 [oxidation-reduction process]
GO:0061045 [negative regulation of wound healing]
GO:0061179 [negative regulation of insulin secretion involved in cellular response to glucose stimulus]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0070402 [NADPH binding]
Show all
 888 aa
97.5 kDa 		No 8
HMGCR-002
ENSP00000426745
ENST00000511206
P04035 [Direct mapping]
3-hydroxy-3-methylglutaryl-coenzyme A reductase
A0A024RAP2 [Target identity:100%; Query identity:100%]
3-hydroxy-3-methylglutaryl coenzyme A reductase
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   8TM proteins predicted by MDM
Plasma proteins
FDA approved drug targets
   Small molecule drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004420 [hydroxymethylglutaryl-CoA reductase (NADPH) activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005778 [peroxisomal membrane]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006695 [cholesterol biosynthetic process]
GO:0008299 [isoprenoid biosynthetic process]
GO:0015936 [coenzyme A metabolic process]
GO:0016021 [integral component of membrane]
GO:0016616 [oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor]
GO:0042282 [hydroxymethylglutaryl-CoA reductase activity]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0050661 [NADP binding]
GO:0050662 [coenzyme binding]
GO:0051262 [protein tetramerization]
GO:0055114 [oxidation-reduction process]
GO:0070402 [NADPH binding]
Show all
 888 aa
97.5 kDa 		No 8
HMGCR-004
ENSP00000340816
ENST00000343975
P04035 [Direct mapping]
3-hydroxy-3-methylglutaryl-coenzyme A reductase
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   8TM proteins predicted by MDM
Plasma proteins
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004420 [hydroxymethylglutaryl-CoA reductase (NADPH) activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005778 [peroxisomal membrane]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006695 [cholesterol biosynthetic process]
GO:0008299 [isoprenoid biosynthetic process]
GO:0015936 [coenzyme A metabolic process]
GO:0016021 [integral component of membrane]
GO:0016616 [oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor]
GO:0042282 [hydroxymethylglutaryl-CoA reductase activity]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0050661 [NADP binding]
GO:0050662 [coenzyme binding]
GO:0051262 [protein tetramerization]
GO:0055114 [oxidation-reduction process]
GO:0070402 [NADPH binding]
Show all
 835 aa
92 kDa 		No 8
HMGCR-005
ENSP00000421378
ENST00000509085
H0Y8K6 [Direct mapping]
3-hydroxy-3-methylglutaryl-coenzyme A reductase
Show all
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004420 [hydroxymethylglutaryl-CoA reductase (NADPH) activity]
GO:0005622 [intracellular]
GO:0008299 [isoprenoid biosynthetic process]
GO:0015936 [coenzyme A metabolic process]
GO:0016616 [oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor]
GO:0050662 [coenzyme binding]
GO:0055114 [oxidation-reduction process]
Show all
 165 aa
17.4 kDa 		No 0
HMGCR-006
ENSP00000420871
ENST00000511986
H0Y8F6 [Direct mapping]
3-hydroxy-3-methylglutaryl-coenzyme A reductase
Show all
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004420 [hydroxymethylglutaryl-CoA reductase (NADPH) activity]
GO:0005622 [intracellular]
GO:0008299 [isoprenoid biosynthetic process]
GO:0015936 [coenzyme A metabolic process]
GO:0016616 [oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor]
GO:0050662 [coenzyme binding]
GO:0055114 [oxidation-reduction process]
Show all
 115 aa
12.3 kDa 		No 0
HMGCR-009
ENSP00000427340
ENST00000507942
D6RIW0 [Direct mapping]
3-hydroxy-3-methylglutaryl-coenzyme A reductase
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   3TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004420 [hydroxymethylglutaryl-CoA reductase (NADPH) activity]
GO:0005622 [intracellular]
GO:0008299 [isoprenoid biosynthetic process]
GO:0015936 [coenzyme A metabolic process]
GO:0016021 [integral component of membrane]
GO:0050662 [coenzyme binding]
GO:0055114 [oxidation-reduction process]
Show all
 111 aa
12.7 kDa 		No 3
HMGCR-010
ENSP00000409100
ENST00000442032
C9JKX7 [Direct mapping]
3-hydroxy-3-methylglutaryl-coenzyme A reductase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004420 [hydroxymethylglutaryl-CoA reductase (NADPH) activity]
GO:0005622 [intracellular]
GO:0008299 [isoprenoid biosynthetic process]
GO:0055114 [oxidation-reduction process]
Show all
 18 aa
2.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.