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GRM6

GENERAL INFORMATION

Gene name

 GRM6

Gene description

 Glutamate receptor, metabotropic 6

Protein class

 Disease related genes
G-protein coupled receptors
Potential drug targets
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Not detected
GTEx:Tissue enhanced (testis)
FANTOM5:Tissue enriched (retina)

Protein evidence

 Evidence at protein level

Protein expression

 Expression in nerve fibers in retina and in neuronals cells.

DATA RELIABILITY

Data reliability
description

 External characterization data supports antibody staining but no internal RNA data available for correlation.

Reliability score

 Supported based on 1 antibody.
HPA014511
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Eye
N/A
Retina
N/A
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Retina

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Not detected
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (testis)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (retina)

GENE INFORMATION

Gene name

 GRM6 (HGNC Symbol)

Synonyms

 CSNB1B, GPRC1F, mGlu6, MGLUR6

Description

 Glutamate receptor, metabotropic 6 (HGNC Symbol)

Entrez gene summary

 L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. [provided by RefSeq, Feb 2012]

Chromosome

 5

Cytoband

 q35.3

Chromosome location (bp)

 178978327 - 178996206

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000113262 (version 83.38)

Entrez gene

 2916

UniProt

 O15303 (UniProt - Evidence at protein level)

neXtProt

 NX_O15303

Antibodypedia

 GRM6 antibodies

PROTEIN BROWSER
GRM6-001
GRM6-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GRM6-001
ENSP00000430767
ENST00000517717
O15303 [Direct mapping]
Metabotropic glutamate receptor 6
Show all
   Family 3 (C) receptors
G-protein coupled receptors
   GPCRs excl olfactory receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Disease related genes
Potential drug targets
Show all
GO:0000139 [Golgi membrane]
GO:0001642 [group III metabotropic glutamate receptor activity]
GO:0004930 [G-protein coupled receptor activity]
GO:0005515 [protein binding]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007196 [adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway]
GO:0007216 [G-protein coupled glutamate receptor signaling pathway]
GO:0008066 [glutamate receptor activity]
GO:0009584 [detection of visible light]
GO:0016021 [integral component of membrane]
GO:0030425 [dendrite]
GO:0042734 [presynaptic membrane]
GO:0042803 [protein homodimerization activity]
GO:0050908 [detection of light stimulus involved in visual perception]
GO:0051966 [regulation of synaptic transmission, glutamatergic]
GO:0090280 [positive regulation of calcium ion import]
Show all
 877 aa
95.5 kDa 		Yes 7
GRM6-201
ENSP00000231188
ENST00000231188
O15303 [Direct mapping]
Metabotropic glutamate receptor 6
Show all
   Family 3 (C) receptors
G-protein coupled receptors
   GPCRs excl olfactory receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0001640 [adenylate cyclase inhibiting G-protein coupled glutamate receptor activity]
GO:0001642 [group III metabotropic glutamate receptor activity]
GO:0004930 [G-protein coupled receptor activity]
GO:0005515 [protein binding]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0007165 [signal transduction]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007196 [adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway]
GO:0007216 [G-protein coupled glutamate receptor signaling pathway]
GO:0007268 [synaptic transmission]
GO:0007626 [locomotory behavior]
GO:0008066 [glutamate receptor activity]
GO:0009584 [detection of visible light]
GO:0016021 [integral component of membrane]
GO:0030425 [dendrite]
GO:0035841 [new growing cell tip]
GO:0042734 [presynaptic membrane]
GO:0042803 [protein homodimerization activity]
GO:0050908 [detection of light stimulus involved in visual perception]
GO:0050953 [sensory perception of light stimulus]
GO:0051966 [regulation of synaptic transmission, glutamatergic]
GO:0060041 [retina development in camera-type eye]
GO:0090280 [positive regulation of calcium ion import]
Show all
 877 aa
95.5 kDa 		Yes 7

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.