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RNA cell line category: Cell line enhanced (MOLT-4, HMC-1, HEL, HDLM-2)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.
Cell lines sorted after biological source for establishment.
Cell lines sorted after the cell line category according to Cellosaurus.
Cell lines sorted on descending RNA expression.
Cell lines sorted alphabetically.
GENE INFORMATION
Gene name
ITK (HGNC Symbol)
Synonyms
EMT, LYK, PSCTK2
Description
IL2-inducible T-cell kinase (HGNC Symbol)
Entrez gene summary
This gene encodes an intracellular tyrosine kinase expressed in T-cells. The protein contains both SH2 and SH3 domains which are often found in intracellular kinases. It is thought to play a role in T-cell proliferation and differentiation. [provided by RefSeq, Jul 2008]
Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001865 [NK T cell differentiation] GO:0002250 [adaptive immune response] GO:0005515 [protein binding] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane] GO:0035556 [intracellular signal transduction] GO:0038083 [peptidyl-tyrosine autophosphorylation] GO:0042127 [regulation of cell proliferation] GO:0045087 [innate immune response] GO:0050852 [T cell receptor signaling pathway]
