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CNOT6

CANCER ATLAS

Gene description

 CCR4-NOT transcription complex, subunit 6

Protein class

 Enzymes, Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA044568

GENE INFORMATION

Gene name

 CNOT6 (HGNC Symbol)

Synonyms

 CCR4, Ccr4a, KIAA1194

Description

 CCR4-NOT transcription complex, subunit 6 (HGNC Symbol)

Entrez gene summary

 This gene encodes the catalytic component of the CCR4-NOT core transcriptional regulation complex. The encoded protein has a 3'-5' RNase activity and prefers polyadenylated substrates. The CCR4-NOT complex plays a role in many cellular processes, including miRNA-mediated repression, mRNA degradation, and transcriptional regulation. [provided by RefSeq, Dec 2014]

Chromosome

 5

Cytoband

 q35.3

Chromosome location (bp)

 180494412 - 180578405

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000113300 (version 83.38)

Entrez gene

 57472

UniProt

 Q9ULM6 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9ULM6

Antibodypedia

 CNOT6 antibodies

PROTEIN BROWSER
CNOT6-001
CNOT6-004
CNOT6-201
CNOT6-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CNOT6-001
ENSP00000377024
ENST00000393356
Q9ULM6 [Direct mapping]
CCR4-NOT transcription complex subunit 6
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000288 [nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay]
GO:0000289 [nuclear-transcribed mRNA poly(A) tail shortening]
GO:0003723 [RNA binding]
GO:0004532 [exoribonuclease activity]
GO:0004535 [poly(A)-specific ribonuclease activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006417 [regulation of translation]
GO:0008284 [positive regulation of cell proliferation]
GO:0010467 [gene expression]
GO:0010606 [positive regulation of cytoplasmic mRNA processing body assembly]
GO:0016020 [membrane]
GO:0030014 [CCR4-NOT complex]
GO:0035195 [gene silencing by miRNA]
GO:0043928 [exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay]
GO:0046872 [metal ion binding]
GO:0070966 [nuclear-transcribed mRNA catabolic process, no-go decay]
GO:0090503 [RNA phosphodiester bond hydrolysis, exonucleolytic]
GO:2000327 [positive regulation of ligand-dependent nuclear receptor transcription coactivator activity]
Show all
 557 aa
63.3 kDa 		No 0
CNOT6-004
ENSP00000422087
ENST00000504343
D6R9H6 [Direct mapping]
CCR4-NOT transcription complex subunit 6
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 235 aa
27.3 kDa 		No 0
CNOT6-201
ENSP00000261951
ENST00000261951
Q9ULM6 [Direct mapping]
CCR4-NOT transcription complex subunit 6
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000288 [nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay]
GO:0000289 [nuclear-transcribed mRNA poly(A) tail shortening]
GO:0003723 [RNA binding]
GO:0004532 [exoribonuclease activity]
GO:0004535 [poly(A)-specific ribonuclease activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006417 [regulation of translation]
GO:0008284 [positive regulation of cell proliferation]
GO:0010467 [gene expression]
GO:0010606 [positive regulation of cytoplasmic mRNA processing body assembly]
GO:0016020 [membrane]
GO:0030014 [CCR4-NOT complex]
GO:0035195 [gene silencing by miRNA]
GO:0043928 [exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay]
GO:0046872 [metal ion binding]
GO:0070966 [nuclear-transcribed mRNA catabolic process, no-go decay]
GO:0090503 [RNA phosphodiester bond hydrolysis, exonucleolytic]
GO:2000327 [positive regulation of ligand-dependent nuclear receptor transcription coactivator activity]
Show all
 557 aa
63.3 kDa 		No 0
CNOT6-202
ENSP00000481893
ENST00000618123
Q9ULM6 [Direct mapping]
CCR4-NOT transcription complex subunit 6
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000288 [nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay]
GO:0000289 [nuclear-transcribed mRNA poly(A) tail shortening]
GO:0003723 [RNA binding]
GO:0004532 [exoribonuclease activity]
GO:0004535 [poly(A)-specific ribonuclease activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006417 [regulation of translation]
GO:0008284 [positive regulation of cell proliferation]
GO:0010467 [gene expression]
GO:0010606 [positive regulation of cytoplasmic mRNA processing body assembly]
GO:0016020 [membrane]
GO:0030014 [CCR4-NOT complex]
GO:0035195 [gene silencing by miRNA]
GO:0043928 [exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay]
GO:0046872 [metal ion binding]
GO:0070966 [nuclear-transcribed mRNA catabolic process, no-go decay]
GO:0090503 [RNA phosphodiester bond hydrolysis, exonucleolytic]
GO:2000327 [positive regulation of ligand-dependent nuclear receptor transcription coactivator activity]
Show all
 557 aa
63.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.