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DROSHA

GENERAL INFORMATION

Gene name

 DROSHA

Gene description

 Drosha, ribonuclease type III

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 7
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

DATA RELIABILITY

Reliability score

 Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
N/A
Hippocampus
N/A
N/A
Caudate
N/A
N/A
Cerebellum
N/A
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Appendix
N/A
Tonsil
N/A
Spleen
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Oral mucosa
N/A
N/A
Esophagus
N/A
Stomach
N/A
Duodenum
N/A
Colon
N/A
Rectum
N/A
Kidney & urinary bladder
N/A
Kidney
N/A
Male tissues
N/A
Testis
N/A
Prostate
N/A
Female tissues
N/A
Breast
N/A
Vagina
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Soft tissue
N/A
N/A
Skin
N/A
Skin
N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 DROSHA (HGNC Symbol)

Synonyms

 Etohi2, HSA242976, RN3, RNASE3L, RNASEN

Description

 Drosha, ribonuclease type III (HGNC Symbol)

Entrez gene summary

 Members of the ribonuclease III superfamily of double-stranded (ds) RNA-specific endoribonucleases participate in diverse RNA maturation and decay pathways in eukaryotic and prokaryotic cells (Fortin et al., 2002 [PubMed 12191433]). The RNase III Drosha is the core nuclease that executes the initiation step of microRNA (miRNA) processing in the nucleus (Lee et al., 2003 [PubMed 14508493]).[supplied by OMIM, Mar 2008]

Chromosome

 5

Cytoband

 p13.3

Chromosome location (bp)

 31400497 - 31532196

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000113360 (version 83.38)

Entrez gene

 29102

UniProt

 Q9NRR4 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NRR4

Antibodypedia

 DROSHA antibodies

PROTEIN BROWSER
DROSHA-002
DROSHA-003
DROSHA-005
DROSHA-009
DROSHA-011
DROSHA-201
DROSHA-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DROSHA-002
ENSP00000425979
ENST00000511367
Q9NRR4 [Direct mapping]
Ribonuclease 3
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001530 [lipopolysaccharide binding]
GO:0003723 [RNA binding]
GO:0003725 [double-stranded RNA binding]
GO:0004521 [endoribonuclease activity]
GO:0004525 [ribonuclease III activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0006396 [RNA processing]
GO:0010467 [gene expression]
GO:0010468 [regulation of gene expression]
GO:0010586 [miRNA metabolic process]
GO:0010628 [positive regulation of gene expression]
GO:0016075 [rRNA catabolic process]
GO:0030422 [production of siRNA involved in RNA interference]
GO:0031047 [gene silencing by RNA]
GO:0031053 [primary miRNA processing]
GO:0031054 [pre-miRNA processing]
GO:0042254 [ribosome biogenesis]
GO:0042803 [protein homodimerization activity]
GO:0044822 [poly(A) RNA binding]
GO:0046872 [metal ion binding]
GO:0050829 [defense response to Gram-negative bacterium]
GO:0050830 [defense response to Gram-positive bacterium]
GO:0070877 [microprocessor complex]
GO:0070878 [primary miRNA binding]
GO:0090501 [RNA phosphodiester bond hydrolysis]
GO:0090502 [RNA phosphodiester bond hydrolysis, endonucleolytic]
GO:2000628 [regulation of miRNA metabolic process]
Show all
 1374 aa
159.3 kDa 		No 0
DROSHA-003
ENSP00000424161
ENST00000513349
Q9NRR4 [Direct mapping]
Ribonuclease 3
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001530 [lipopolysaccharide binding]
GO:0003723 [RNA binding]
GO:0003725 [double-stranded RNA binding]
GO:0004525 [ribonuclease III activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0006396 [RNA processing]
GO:0010467 [gene expression]
GO:0016075 [rRNA catabolic process]
GO:0030422 [production of siRNA involved in RNA interference]
GO:0031047 [gene silencing by RNA]
GO:0031053 [primary miRNA processing]
GO:0031054 [pre-miRNA processing]
GO:0042254 [ribosome biogenesis]
GO:0042803 [protein homodimerization activity]
GO:0044822 [poly(A) RNA binding]
GO:0046872 [metal ion binding]
GO:0050829 [defense response to Gram-negative bacterium]
GO:0050830 [defense response to Gram-positive bacterium]
GO:0070877 [microprocessor complex]
GO:0070878 [primary miRNA binding]
GO:0090501 [RNA phosphodiester bond hydrolysis]
GO:0090502 [RNA phosphodiester bond hydrolysis, endonucleolytic]
Show all
 1337 aa
155.3 kDa 		No 0
DROSHA-005
ENSP00000430921
ENST00000507438
E5RHD1 [Direct mapping]
Ribonuclease 3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003725 [double-stranded RNA binding]
GO:0005634 [nucleus]
GO:0030422 [production of siRNA involved in RNA interference]
GO:0031054 [pre-miRNA processing]
Show all
 201 aa
22 kDa 		No 0
DROSHA-009
ENSP00000422745
ENST00000512076
H7C5U6 [Direct mapping]
Ribonuclease 3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003725 [double-stranded RNA binding]
GO:0005634 [nucleus]
GO:0030422 [production of siRNA involved in RNA interference]
GO:0031054 [pre-miRNA processing]
Show all
 375 aa
43.8 kDa 		No 0
DROSHA-011
ENSP00000428782
ENST00000512302
H0YB67 [Direct mapping]
Ribonuclease 3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003725 [double-stranded RNA binding]
GO:0005634 [nucleus]
GO:0030422 [production of siRNA involved in RNA interference]
GO:0031054 [pre-miRNA processing]
Show all
 195 aa
23.4 kDa 		No 0
DROSHA-201
ENSP00000339845
ENST00000344624
Q9NRR4 [Direct mapping]
Ribonuclease 3
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001530 [lipopolysaccharide binding]
GO:0003723 [RNA binding]
GO:0003725 [double-stranded RNA binding]
GO:0004525 [ribonuclease III activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0006396 [RNA processing]
GO:0010467 [gene expression]
GO:0016075 [rRNA catabolic process]
GO:0030422 [production of siRNA involved in RNA interference]
GO:0031047 [gene silencing by RNA]
GO:0031053 [primary miRNA processing]
GO:0031054 [pre-miRNA processing]
GO:0042254 [ribosome biogenesis]
GO:0042803 [protein homodimerization activity]
GO:0044822 [poly(A) RNA binding]
GO:0046872 [metal ion binding]
GO:0050829 [defense response to Gram-negative bacterium]
GO:0050830 [defense response to Gram-positive bacterium]
GO:0070877 [microprocessor complex]
GO:0070878 [primary miRNA binding]
GO:0090501 [RNA phosphodiester bond hydrolysis]
GO:0090502 [RNA phosphodiester bond hydrolysis, endonucleolytic]
Show all
 1374 aa
159.3 kDa 		No 0
DROSHA-202
ENSP00000409335
ENST00000442743
Q9NRR4 [Direct mapping]
Ribonuclease 3
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001530 [lipopolysaccharide binding]
GO:0003723 [RNA binding]
GO:0003725 [double-stranded RNA binding]
GO:0004525 [ribonuclease III activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0006396 [RNA processing]
GO:0010467 [gene expression]
GO:0016075 [rRNA catabolic process]
GO:0030422 [production of siRNA involved in RNA interference]
GO:0031047 [gene silencing by RNA]
GO:0031053 [primary miRNA processing]
GO:0031054 [pre-miRNA processing]
GO:0042254 [ribosome biogenesis]
GO:0042803 [protein homodimerization activity]
GO:0044822 [poly(A) RNA binding]
GO:0046872 [metal ion binding]
GO:0050829 [defense response to Gram-negative bacterium]
GO:0050830 [defense response to Gram-positive bacterium]
GO:0070877 [microprocessor complex]
GO:0070878 [primary miRNA binding]
GO:0090501 [RNA phosphodiester bond hydrolysis]
GO:0090502 [RNA phosphodiester bond hydrolysis, endonucleolytic]
Show all
 1337 aa
155.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.