Expression of CDH6 in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Cadherin 6, type 2, K-cadherin (fetal kidney)

Protein class

Plasma proteins, Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Renal cancer

STAINING SUMMARY

HPA007047	HPA007456	CAB025274

GENE INFORMATION
Gene name	CDH6
Synonyms
Description	Cadherin 6, type 2, K-cadherin (fetal kidney) (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the cadherin superfamily. Cadherins are membrane glycoproteins that mediate homophilic cell-cell adhesion and play critical roles in cell differentiation and morphogenesis. The encoded protein is a type II cadherin and may play a role in kidney development as well as endometrium and placenta formation. Decreased expression of this gene may be associated with tumor growth and metastasis. [provided by RefSeq, May 2011]
Chromosome	5
Cytoband	p13.3
Chromosome location (bp)	31193750 - 31329146
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000113361 (version 83.38)
Entrez gene	1004
UniProt	P55285 (UniProt - Evidence at protein level)
neXtProt	NX_P55285
Antibodypedia	CDH6 antibodies

PROTEIN BROWSER

CDH6-001	CDH6-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CDH6-001 ENSP00000265071 ENST00000265071	P55285 [Direct mapping] Cadherin-6 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005886 [plasma membrane] GO:0007155 [cell adhesion] GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules] GO:0007219 [Notch signaling pathway] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0034329 [cell junction assembly] GO:0034332 [adherens junction organization] GO:0045216 [cell-cell junction organization] GO:0070062 [extracellular exosome] Show all	790 aa 88.3 kDa	Yes	1
CDH6-003 ENSP00000424843 ENST00000514738	D6RF86 [Direct mapping] Cadherin-6 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005886 [plasma membrane] GO:0007155 [cell adhesion] GO:0007156 [homophilic cell adhesion via plasma membrane adhesion molecules] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	608 aa 67.4 kDa	No	1