Expression of LMNB1 in cancer - Summary

CANCER ATLAS

Gene description

Lamin B1

Protein class

Disease related genes, Plasma proteins, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA050524	HPA053579	CAB005269

GENE INFORMATION
Gene name	LMNB1
Synonyms
Description	Lamin B1 (HGNC Symbol)
Entrez gene summary	The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. This gene encodes one of the two B type proteins, B1. Alternative splicing results in transcript variants and a duplication of this gene is associated with autosomal dominant adult-onset leukodystrophy (ADLD). [provided by RefSeq, Oct 2010]
Chromosome	5
Cytoband	q23.2
Chromosome location (bp)	126776623 - 126837020
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000113368 (version 83.38)
Entrez gene	4001
UniProt	P20700 (UniProt - Evidence at protein level)
neXtProt	NX_P20700
Antibodypedia	LMNB1 antibodies

PROTEIN BROWSER

LMNB1-001	LMNB1-003	LMNB1-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LMNB1-001 ENSP00000261366 ENST00000261366	P20700 [Direct mapping] Lamin-B1 Show all	Predicted intracellular proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005198 [structural molecule activity] GO:0005634 [nucleus] GO:0005635 [nuclear envelope] GO:0005637 [nuclear inner membrane] GO:0005638 [lamin filament] GO:0005654 [nucleoplasm] GO:0005882 [intermediate filament] GO:0006915 [apoptotic process] GO:0006921 [cellular component disassembly involved in execution phase of apoptosis] GO:0012501 [programmed cell death] GO:0016020 [membrane] GO:0016363 [nuclear matrix] GO:0031965 [nuclear membrane] GO:0043274 [phospholipase binding] Show all	586 aa 66.4 kDa	No	0
LMNB1-003 ENSP00000378761 ENST00000395354	E9PBF6 [Direct mapping] Lamin-B1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005198 [structural molecule activity] GO:0005637 [nuclear inner membrane] GO:0005638 [lamin filament] GO:0005882 [intermediate filament] Show all	387 aa 44.6 kDa	No	0
LMNB1-005 ENSP00000486992 ENST00000492190	A0A0D9SFY5 [Direct mapping] Lamin-B1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005198 [structural molecule activity] GO:0005637 [nuclear inner membrane] GO:0005638 [lamin filament] GO:0005882 [intermediate filament] Show all	166 aa 18.5 kDa	No	0