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PDE4D

GENERAL INFORMATION

Gene name

 PDE4D

Gene description

 Phosphodiesterase 4D, cAMP-specific

Protein class

 Disease related genes
Enzymes
FDA approved drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 14
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Tissue enhanced (skeletal muscle)
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Ubiquitous cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA045895
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (skeletal muscle)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 PDE4D (HGNC Symbol)

Synonyms

 DPDE3

Description

 Phosphodiesterase 4D, cAMP-specific (HGNC Symbol)

Entrez gene summary

 This gene encodes one of four mammalian counterparts to the fruit fly 'dunce' gene. The encoded protein has 3',5'-cyclic-AMP phosphodiesterase activity and degrades cAMP, which acts as a signal transduction molecule in multiple cell types. This gene uses different promoters to generate multiple alternatively spliced transcript variants that encode functional proteins.[provided by RefSeq, Sep 2009]

Chromosome

 5

Cytoband

Chromosome location (bp)

 58969038 - 60522120

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000113448 (version 83.38)

Entrez gene

 5144

UniProt

 Q08499 (UniProt - Evidence at protein level)

neXtProt

 NX_Q08499

Antibodypedia

 PDE4D antibodies

PROTEIN BROWSER
«
PDE4D-001
PDE4D-003
PDE4D-009
PDE4D-010
PDE4D-011
PDE4D-012
PDE4D-014
PDE4D-015
PDE4D-016
PDE4D-017
PDE4D-019
PDE4D-020
PDE4D-021
PDE4D-201
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PDE4D-001
ENSP00000345502
ENST00000340635
Q08499 [Direct mapping]
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002027 [regulation of heart rate]
GO:0004114 [3',5'-cyclic-nucleotide phosphodiesterase activity]
GO:0004115 [3',5'-cyclic-AMP phosphodiesterase activity]
GO:0005515 [protein binding]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0005891 [voltage-gated calcium channel complex]
GO:0006198 [cAMP catabolic process]
GO:0006939 [smooth muscle contraction]
GO:0007165 [signal transduction]
GO:0007568 [aging]
GO:0008081 [phosphoric diester hydrolase activity]
GO:0008144 [drug binding]
GO:0010469 [regulation of receptor activity]
GO:0010880 [regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum]
GO:0016020 [membrane]
GO:0016324 [apical plasma membrane]
GO:0019899 [enzyme binding]
GO:0019933 [cAMP-mediated signaling]
GO:0030552 [cAMP binding]
GO:0030593 [neutrophil chemotaxis]
GO:0030814 [regulation of cAMP metabolic process]
GO:0031625 [ubiquitin protein ligase binding]
GO:0031698 [beta-2 adrenergic receptor binding]
GO:0032729 [positive regulation of interferon-gamma production]
GO:0032743 [positive regulation of interleukin-2 production]
GO:0032754 [positive regulation of interleukin-5 production]
GO:0033137 [negative regulation of peptidyl-serine phosphorylation]
GO:0034704 [calcium channel complex]
GO:0035264 [multicellular organism growth]
GO:0044325 [ion channel binding]
GO:0045822 [negative regulation of heart contraction]
GO:0046872 [metal ion binding]
GO:0050852 [T cell receptor signaling pathway]
GO:0050900 [leukocyte migration]
GO:0051117 [ATPase binding]
GO:0060314 [regulation of ryanodine-sensitive calcium-release channel activity]
GO:0061028 [establishment of endothelial barrier]
GO:0071222 [cellular response to lipopolysaccharide]
GO:0071320 [cellular response to cAMP]
GO:0071872 [cellular response to epinephrine stimulus]
GO:0071875 [adrenergic receptor signaling pathway]
GO:0086004 [regulation of cardiac muscle cell contraction]
GO:0086024 [adrenergic receptor signaling pathway involved in positive regulation of heart rate]
GO:0097110 [scaffold protein binding]
GO:1901844 [regulation of cell communication by electrical coupling involved in cardiac conduction]
GO:1901898 [negative regulation of relaxation of cardiac muscle]
Show all
 809 aa
91.1 kDa 		No 0
PDE4D-003
ENSP00000423094
ENST00000502484
Q08499 [Direct mapping]
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002027 [regulation of heart rate]
GO:0004114 [3',5'-cyclic-nucleotide phosphodiesterase activity]
GO:0004115 [3',5'-cyclic-AMP phosphodiesterase activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005891 [voltage-gated calcium channel complex]
GO:0006198 [cAMP catabolic process]
GO:0007165 [signal transduction]
GO:0008081 [phosphoric diester hydrolase activity]
GO:0008144 [drug binding]
GO:0010469 [regulation of receptor activity]
GO:0010880 [regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum]
GO:0016020 [membrane]
GO:0016324 [apical plasma membrane]
GO:0019899 [enzyme binding]
GO:0019933 [cAMP-mediated signaling]
GO:0030552 [cAMP binding]
GO:0031625 [ubiquitin protein ligase binding]
GO:0031698 [beta-2 adrenergic receptor binding]
GO:0032729 [positive regulation of interferon-gamma production]
GO:0032743 [positive regulation of interleukin-2 production]
GO:0032754 [positive regulation of interleukin-5 production]
GO:0033137 [negative regulation of peptidyl-serine phosphorylation]
GO:0034704 [calcium channel complex]
GO:0044325 [ion channel binding]
GO:0045822 [negative regulation of heart contraction]
GO:0046872 [metal ion binding]
GO:0050852 [T cell receptor signaling pathway]
GO:0051117 [ATPase binding]
GO:0060314 [regulation of ryanodine-sensitive calcium-release channel activity]
GO:0061028 [establishment of endothelial barrier]
GO:0071320 [cellular response to cAMP]
GO:0071872 [cellular response to epinephrine stimulus]
GO:0071875 [adrenergic receptor signaling pathway]
GO:0086004 [regulation of cardiac muscle cell contraction]
GO:0086024 [adrenergic receptor signaling pathway involved in positive regulation of heart rate]
GO:0097110 [scaffold protein binding]
GO:1901844 [regulation of cell communication by electrical coupling involved in cardiac conduction]
GO:1901898 [negative regulation of relaxation of cardiac muscle]
Show all
 748 aa
84.7 kDa 		No 0
PDE4D-009
ENSP00000425910
ENST00000505507
D6RIG1 [Direct mapping]
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 81 aa
9.4 kDa 		No 0
PDE4D-010
ENSP00000424281
ENST00000515835
D6RBB2 [Direct mapping]
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 29 aa
3.4 kDa 		No 0
PDE4D-011
ENSP00000425917
ENST00000502575
Q08499 [Direct mapping]
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002027 [regulation of heart rate]
GO:0004114 [3',5'-cyclic-nucleotide phosphodiesterase activity]
GO:0004115 [3',5'-cyclic-AMP phosphodiesterase activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005891 [voltage-gated calcium channel complex]
GO:0006198 [cAMP catabolic process]
GO:0008144 [drug binding]
GO:0010469 [regulation of receptor activity]
GO:0010880 [regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum]
GO:0016020 [membrane]
GO:0016324 [apical plasma membrane]
GO:0019899 [enzyme binding]
GO:0019933 [cAMP-mediated signaling]
GO:0030552 [cAMP binding]
GO:0031625 [ubiquitin protein ligase binding]
GO:0031698 [beta-2 adrenergic receptor binding]
GO:0032729 [positive regulation of interferon-gamma production]
GO:0032743 [positive regulation of interleukin-2 production]
GO:0032754 [positive regulation of interleukin-5 production]
GO:0033137 [negative regulation of peptidyl-serine phosphorylation]
GO:0034704 [calcium channel complex]
GO:0044325 [ion channel binding]
GO:0045822 [negative regulation of heart contraction]
GO:0046872 [metal ion binding]
GO:0050852 [T cell receptor signaling pathway]
GO:0051117 [ATPase binding]
GO:0060314 [regulation of ryanodine-sensitive calcium-release channel activity]
GO:0061028 [establishment of endothelial barrier]
GO:0071320 [cellular response to cAMP]
GO:0071872 [cellular response to epinephrine stimulus]
GO:0071875 [adrenergic receptor signaling pathway]
GO:0086004 [regulation of cardiac muscle cell contraction]
GO:0086024 [adrenergic receptor signaling pathway involved in positive regulation of heart rate]
GO:0097110 [scaffold protein binding]
GO:1901844 [regulation of cell communication by electrical coupling involved in cardiac conduction]
GO:1901898 [negative regulation of relaxation of cardiac muscle]
Show all
 219 aa
24.4 kDa 		No 0
PDE4D-012
ENSP00000424852
ENST00000507116
Q08499 [Direct mapping]
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002027 [regulation of heart rate]
GO:0004114 [3',5'-cyclic-nucleotide phosphodiesterase activity]
GO:0004115 [3',5'-cyclic-AMP phosphodiesterase activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005891 [voltage-gated calcium channel complex]
GO:0006198 [cAMP catabolic process]
GO:0007165 [signal transduction]
GO:0008081 [phosphoric diester hydrolase activity]
GO:0008144 [drug binding]
GO:0010469 [regulation of receptor activity]
GO:0010880 [regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum]
GO:0016020 [membrane]
GO:0016324 [apical plasma membrane]
GO:0019899 [enzyme binding]
GO:0019933 [cAMP-mediated signaling]
GO:0030552 [cAMP binding]
GO:0031625 [ubiquitin protein ligase binding]
GO:0031698 [beta-2 adrenergic receptor binding]
GO:0032729 [positive regulation of interferon-gamma production]
GO:0032743 [positive regulation of interleukin-2 production]
GO:0032754 [positive regulation of interleukin-5 production]
GO:0033137 [negative regulation of peptidyl-serine phosphorylation]
GO:0034704 [calcium channel complex]
GO:0044325 [ion channel binding]
GO:0045822 [negative regulation of heart contraction]
GO:0046872 [metal ion binding]
GO:0050852 [T cell receptor signaling pathway]
GO:0051117 [ATPase binding]
GO:0060314 [regulation of ryanodine-sensitive calcium-release channel activity]
GO:0061028 [establishment of endothelial barrier]
GO:0071320 [cellular response to cAMP]
GO:0071872 [cellular response to epinephrine stimulus]
GO:0071875 [adrenergic receptor signaling pathway]
GO:0086004 [regulation of cardiac muscle cell contraction]
GO:0086024 [adrenergic receptor signaling pathway involved in positive regulation of heart rate]
GO:0097110 [scaffold protein binding]
GO:1901844 [regulation of cell communication by electrical coupling involved in cardiac conduction]
GO:1901898 [negative regulation of relaxation of cardiac muscle]
Show all
 745 aa
84.4 kDa 		No 0
PDE4D-014
ENSP00000353152
ENST00000360047
Q08499 [Direct mapping]
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002027 [regulation of heart rate]
GO:0004114 [3',5'-cyclic-nucleotide phosphodiesterase activity]
GO:0004115 [3',5'-cyclic-AMP phosphodiesterase activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005891 [voltage-gated calcium channel complex]
GO:0006198 [cAMP catabolic process]
GO:0007165 [signal transduction]
GO:0008081 [phosphoric diester hydrolase activity]
GO:0008144 [drug binding]
GO:0010469 [regulation of receptor activity]
GO:0010880 [regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum]
GO:0016020 [membrane]
GO:0016324 [apical plasma membrane]
GO:0019899 [enzyme binding]
GO:0019933 [cAMP-mediated signaling]
GO:0030552 [cAMP binding]
GO:0031625 [ubiquitin protein ligase binding]
GO:0031698 [beta-2 adrenergic receptor binding]
GO:0032729 [positive regulation of interferon-gamma production]
GO:0032743 [positive regulation of interleukin-2 production]
GO:0032754 [positive regulation of interleukin-5 production]
GO:0033137 [negative regulation of peptidyl-serine phosphorylation]
GO:0034704 [calcium channel complex]
GO:0044325 [ion channel binding]
GO:0045822 [negative regulation of heart contraction]
GO:0046872 [metal ion binding]
GO:0050852 [T cell receptor signaling pathway]
GO:0051117 [ATPase binding]
GO:0060314 [regulation of ryanodine-sensitive calcium-release channel activity]
GO:0061028 [establishment of endothelial barrier]
GO:0071320 [cellular response to cAMP]
GO:0071872 [cellular response to epinephrine stimulus]
GO:0071875 [adrenergic receptor signaling pathway]
GO:0086004 [regulation of cardiac muscle cell contraction]
GO:0086024 [adrenergic receptor signaling pathway involved in positive regulation of heart rate]
GO:0097110 [scaffold protein binding]
GO:1901844 [regulation of cell communication by electrical coupling involved in cardiac conduction]
GO:1901898 [negative regulation of relaxation of cardiac muscle]
Show all
 673 aa
76.5 kDa 		No 0
PDE4D-015
ENSP00000384806
ENST00000405755
Q08499 [Direct mapping]
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002027 [regulation of heart rate]
GO:0004114 [3',5'-cyclic-nucleotide phosphodiesterase activity]
GO:0004115 [3',5'-cyclic-AMP phosphodiesterase activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005891 [voltage-gated calcium channel complex]
GO:0006198 [cAMP catabolic process]
GO:0007165 [signal transduction]
GO:0008081 [phosphoric diester hydrolase activity]
GO:0008144 [drug binding]
GO:0010469 [regulation of receptor activity]
GO:0010880 [regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum]
GO:0016020 [membrane]
GO:0016324 [apical plasma membrane]
GO:0019899 [enzyme binding]
GO:0019933 [cAMP-mediated signaling]
GO:0030552 [cAMP binding]
GO:0031625 [ubiquitin protein ligase binding]
GO:0031698 [beta-2 adrenergic receptor binding]
GO:0032729 [positive regulation of interferon-gamma production]
GO:0032743 [positive regulation of interleukin-2 production]
GO:0032754 [positive regulation of interleukin-5 production]
GO:0033137 [negative regulation of peptidyl-serine phosphorylation]
GO:0034704 [calcium channel complex]
GO:0044325 [ion channel binding]
GO:0045822 [negative regulation of heart contraction]
GO:0046872 [metal ion binding]
GO:0050852 [T cell receptor signaling pathway]
GO:0051117 [ATPase binding]
GO:0060314 [regulation of ryanodine-sensitive calcium-release channel activity]
GO:0061028 [establishment of endothelial barrier]
GO:0071320 [cellular response to cAMP]
GO:0071872 [cellular response to epinephrine stimulus]
GO:0071875 [adrenergic receptor signaling pathway]
GO:0086004 [regulation of cardiac muscle cell contraction]
GO:0086024 [adrenergic receptor signaling pathway involved in positive regulation of heart rate]
GO:0097110 [scaffold protein binding]
GO:1901844 [regulation of cell communication by electrical coupling involved in cardiac conduction]
GO:1901898 [negative regulation of relaxation of cardiac muscle]
Show all
 687 aa
77.7 kDa 		No 0
PDE4D-016
ENSP00000425605
ENST00000503258
Q08499 [Direct mapping]
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002027 [regulation of heart rate]
GO:0004114 [3',5'-cyclic-nucleotide phosphodiesterase activity]
GO:0004115 [3',5'-cyclic-AMP phosphodiesterase activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005891 [voltage-gated calcium channel complex]
GO:0006198 [cAMP catabolic process]
GO:0007165 [signal transduction]
GO:0008081 [phosphoric diester hydrolase activity]
GO:0008144 [drug binding]
GO:0010469 [regulation of receptor activity]
GO:0010880 [regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum]
GO:0016020 [membrane]
GO:0016324 [apical plasma membrane]
GO:0019899 [enzyme binding]
GO:0019933 [cAMP-mediated signaling]
GO:0030552 [cAMP binding]
GO:0031625 [ubiquitin protein ligase binding]
GO:0031698 [beta-2 adrenergic receptor binding]
GO:0032729 [positive regulation of interferon-gamma production]
GO:0032743 [positive regulation of interleukin-2 production]
GO:0032754 [positive regulation of interleukin-5 production]
GO:0033137 [negative regulation of peptidyl-serine phosphorylation]
GO:0034704 [calcium channel complex]
GO:0044325 [ion channel binding]
GO:0045822 [negative regulation of heart contraction]
GO:0046872 [metal ion binding]
GO:0050852 [T cell receptor signaling pathway]
GO:0051117 [ATPase binding]
GO:0060314 [regulation of ryanodine-sensitive calcium-release channel activity]
GO:0061028 [establishment of endothelial barrier]
GO:0071320 [cellular response to cAMP]
GO:0071872 [cellular response to epinephrine stimulus]
GO:0071875 [adrenergic receptor signaling pathway]
GO:0086004 [regulation of cardiac muscle cell contraction]
GO:0086024 [adrenergic receptor signaling pathway involved in positive regulation of heart rate]
GO:0097110 [scaffold protein binding]
GO:1901844 [regulation of cell communication by electrical coupling involved in cardiac conduction]
GO:1901898 [negative regulation of relaxation of cardiac muscle]
Show all
 679 aa
76.8 kDa 		No 0
PDE4D-017
ENSP00000421013
ENST00000505453
D6RHE0 [Direct mapping]
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004114 [3',5'-cyclic-nucleotide phosphodiesterase activity]
GO:0007165 [signal transduction]
GO:0008081 [phosphoric diester hydrolase activity]
GO:0008152 [metabolic process]
GO:0046872 [metal ion binding]
Show all
 422 aa
48.4 kDa 		No 0
PDE4D-019
ENSP00000351800
ENST00000358923
Q08499 [Direct mapping]
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002027 [regulation of heart rate]
GO:0004114 [3',5'-cyclic-nucleotide phosphodiesterase activity]
GO:0004115 [3',5'-cyclic-AMP phosphodiesterase activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005891 [voltage-gated calcium channel complex]
GO:0006198 [cAMP catabolic process]
GO:0007165 [signal transduction]
GO:0008081 [phosphoric diester hydrolase activity]
GO:0008144 [drug binding]
GO:0010469 [regulation of receptor activity]
GO:0010880 [regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum]
GO:0016020 [membrane]
GO:0016324 [apical plasma membrane]
GO:0019899 [enzyme binding]
GO:0019933 [cAMP-mediated signaling]
GO:0030552 [cAMP binding]
GO:0031625 [ubiquitin protein ligase binding]
GO:0031698 [beta-2 adrenergic receptor binding]
GO:0032729 [positive regulation of interferon-gamma production]
GO:0032743 [positive regulation of interleukin-2 production]
GO:0032754 [positive regulation of interleukin-5 production]
GO:0033137 [negative regulation of peptidyl-serine phosphorylation]
GO:0034704 [calcium channel complex]
GO:0044325 [ion channel binding]
GO:0045822 [negative regulation of heart contraction]
GO:0046872 [metal ion binding]
GO:0050852 [T cell receptor signaling pathway]
GO:0051117 [ATPase binding]
GO:0060314 [regulation of ryanodine-sensitive calcium-release channel activity]
GO:0061028 [establishment of endothelial barrier]
GO:0071320 [cellular response to cAMP]
GO:0071872 [cellular response to epinephrine stimulus]
GO:0071875 [adrenergic receptor signaling pathway]
GO:0086004 [regulation of cardiac muscle cell contraction]
GO:0086024 [adrenergic receptor signaling pathway involved in positive regulation of heart rate]
GO:0097110 [scaffold protein binding]
GO:1901844 [regulation of cell communication by electrical coupling involved in cardiac conduction]
GO:1901898 [negative regulation of relaxation of cardiac muscle]
Show all
 507 aa
57.8 kDa 		No 0
PDE4D-020
ENSP00000321739
ENST00000317118
Q08499 [Direct mapping]
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002027 [regulation of heart rate]
GO:0004114 [3',5'-cyclic-nucleotide phosphodiesterase activity]
GO:0004115 [3',5'-cyclic-AMP phosphodiesterase activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005891 [voltage-gated calcium channel complex]
GO:0006198 [cAMP catabolic process]
GO:0007165 [signal transduction]
GO:0008081 [phosphoric diester hydrolase activity]
GO:0008144 [drug binding]
GO:0010469 [regulation of receptor activity]
GO:0010880 [regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum]
GO:0016020 [membrane]
GO:0016324 [apical plasma membrane]
GO:0019899 [enzyme binding]
GO:0019933 [cAMP-mediated signaling]
GO:0030552 [cAMP binding]
GO:0031625 [ubiquitin protein ligase binding]
GO:0031698 [beta-2 adrenergic receptor binding]
GO:0032729 [positive regulation of interferon-gamma production]
GO:0032743 [positive regulation of interleukin-2 production]
GO:0032754 [positive regulation of interleukin-5 production]
GO:0033137 [negative regulation of peptidyl-serine phosphorylation]
GO:0034704 [calcium channel complex]
GO:0044325 [ion channel binding]
GO:0045822 [negative regulation of heart contraction]
GO:0046872 [metal ion binding]
GO:0050852 [T cell receptor signaling pathway]
GO:0051117 [ATPase binding]
GO:0060314 [regulation of ryanodine-sensitive calcium-release channel activity]
GO:0061028 [establishment of endothelial barrier]
GO:0071320 [cellular response to cAMP]
GO:0071872 [cellular response to epinephrine stimulus]
GO:0071875 [adrenergic receptor signaling pathway]
GO:0086004 [regulation of cardiac muscle cell contraction]
GO:0086024 [adrenergic receptor signaling pathway involved in positive regulation of heart rate]
GO:0097110 [scaffold protein binding]
GO:1901844 [regulation of cell communication by electrical coupling involved in cardiac conduction]
GO:1901898 [negative regulation of relaxation of cardiac muscle]
Show all
 518 aa
59.1 kDa 		No 0
PDE4D-021
ENSP00000421829
ENST00000514552
D6RAQ0 [Direct mapping]
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 75 aa
8.7 kDa 		No 0
PDE4D-201
ENSP00000442734
ENST00000546160
A0A087WSZ7 [Direct mapping]
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004114 [3',5'-cyclic-nucleotide phosphodiesterase activity]
GO:0007165 [signal transduction]
GO:0008081 [phosphoric diester hydrolase activity]
GO:0008152 [metabolic process]
Show all
 678 aa
77 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.