Tissue expression of PRLR - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	PRLR
Gene description	Prolactin receptor
Protein class	Disease related genes FDA approved drug targets Predicted membrane proteins Predicted secreted proteins
Predicted localization	Membrane,Secreted
Number of transcripts	16
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (placenta)
GTEx:	Tissue enhanced (cervix, uterine)
FANTOM5:	Tissue enhanced (seminal vesicle, placenta)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (placenta)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (cervix, uterine)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (seminal vesicle, placenta)

GENE INFORMATION
Gene name	PRLR
Synonyms
Description	Prolactin receptor (HGNC Symbol)
Entrez gene summary	This gene encodes a receptor for the anterior pituitary hormone, prolactin, and belongs to the type I cytokine receptor family. Prolactin-dependent signaling occurs as the result of ligand-induced dimerization of the prolactin receptor. Several alternatively spliced transcript variants encoding different membrane-bound and soluble isoforms have been described for this gene, which may function to modulate the endocrine and autocrine effects of prolactin in normal tissue and cancer. [provided by RefSeq, Feb 2011]
Chromosome	5
Cytoband	p13.2
Chromosome location (bp)	35048756 - 35230589
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000113494 (version 83.38)
Entrez gene	5618
UniProt	P16471 (UniProt - Evidence at protein level)
neXtProt	NX_P16471
Antibodypedia	PRLR antibodies

PROTEIN BROWSER

PRLR-001	PRLR-004	PRLR-006	PRLR-007	PRLR-008	PRLR-009	PRLR-011	PRLR-012	PRLR-013	PRLR-014	PRLR-015	PRLR-201	PRLR-202	PRLR-203	PRLR-204	PRLR-205

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PRLR-001 ENSP00000482954 ENST00000618457	P16471 [Direct mapping] Prolactin receptor Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes FDA approved drug targets Biotech drugs Small molecule drugs Show all	GO:0004896 [cytokine receptor activity] GO:0004925 [prolactin receptor activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005622 [intracellular] GO:0005886 [plasma membrane] GO:0006694 [steroid biosynthetic process] GO:0007166 [cell surface receptor signaling pathway] GO:0007171 [activation of transmembrane receptor protein tyrosine kinase activity] GO:0007259 [JAK-STAT cascade] GO:0007566 [embryo implantation] GO:0007595 [lactation] GO:0009986 [cell surface] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0017046 [peptide hormone binding] GO:0030155 [regulation of cell adhesion] GO:0030856 [regulation of epithelial cell differentiation] GO:0031904 [endosome lumen] GO:0038161 [prolactin signaling pathway] GO:0042110 [T cell activation] GO:0042803 [protein homodimerization activity] GO:0042977 [activation of JAK2 kinase activity] GO:0042978 [ornithine decarboxylase activator activity] GO:0043066 [negative regulation of apoptotic process] GO:0046872 [metal ion binding] GO:0060397 [JAK-STAT cascade involved in growth hormone signaling pathway] GO:0060644 [mammary gland epithelial cell differentiation] GO:0060736 [prostate gland growth] GO:0060749 [mammary gland alveolus development] GO:0061180 [mammary gland epithelium development] Show all	622 aa 69.5 kDa	Yes	1
PRLR-004 ENSP00000311613 ENST00000348262	P16471 [Direct mapping] Prolactin receptor Show all	MEMSAT3 predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes FDA approved drug targets Biotech drugs Small molecule drugs Show all	GO:0004896 [cytokine receptor activity] GO:0004925 [prolactin receptor activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005886 [plasma membrane] GO:0006694 [steroid biosynthetic process] GO:0007166 [cell surface receptor signaling pathway] GO:0007171 [activation of transmembrane receptor protein tyrosine kinase activity] GO:0007566 [embryo implantation] GO:0007595 [lactation] GO:0009986 [cell surface] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0017046 [peptide hormone binding] GO:0031904 [endosome lumen] GO:0042110 [T cell activation] GO:0042803 [protein homodimerization activity] GO:0042977 [activation of JAK2 kinase activity] GO:0042978 [ornithine decarboxylase activator activity] GO:0043066 [negative regulation of apoptotic process] GO:0046872 [metal ion binding] GO:0060397 [JAK-STAT cascade involved in growth hormone signaling pathway] Show all	268 aa 30.7 kDa	Yes	0
PRLR-006 ENSP00000231423 ENST00000231423	P16471 [Direct mapping] Prolactin receptor Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes FDA approved drug targets Biotech drugs Small molecule drugs Show all	GO:0004896 [cytokine receptor activity] GO:0004925 [prolactin receptor activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005886 [plasma membrane] GO:0006694 [steroid biosynthetic process] GO:0007166 [cell surface receptor signaling pathway] GO:0007171 [activation of transmembrane receptor protein tyrosine kinase activity] GO:0007566 [embryo implantation] GO:0007595 [lactation] GO:0009986 [cell surface] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0017046 [peptide hormone binding] GO:0031904 [endosome lumen] GO:0042110 [T cell activation] GO:0042803 [protein homodimerization activity] GO:0042977 [activation of JAK2 kinase activity] GO:0042978 [ornithine decarboxylase activator activity] GO:0043066 [negative regulation of apoptotic process] GO:0046872 [metal ion binding] GO:0060397 [JAK-STAT cascade involved in growth hormone signaling pathway] Show all	376 aa 42.6 kDa	Yes	1
PRLR-007 ENSP00000424841 ENST00000513753	P16471 [Direct mapping] Prolactin receptor Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes FDA approved drug targets Biotech drugs Small molecule drugs Show all	GO:0004896 [cytokine receptor activity] GO:0004925 [prolactin receptor activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005886 [plasma membrane] GO:0006694 [steroid biosynthetic process] GO:0007166 [cell surface receptor signaling pathway] GO:0007171 [activation of transmembrane receptor protein tyrosine kinase activity] GO:0007566 [embryo implantation] GO:0007595 [lactation] GO:0009986 [cell surface] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0017046 [peptide hormone binding] GO:0031904 [endosome lumen] GO:0042110 [T cell activation] GO:0042803 [protein homodimerization activity] GO:0042977 [activation of JAK2 kinase activity] GO:0042978 [ornithine decarboxylase activator activity] GO:0043066 [negative regulation of apoptotic process] GO:0046872 [metal ion binding] GO:0060397 [JAK-STAT cascade involved in growth hormone signaling pathway] Show all	288 aa 32.8 kDa	Yes	1
PRLR-008 ENSP00000422556 ENST00000511486	P16471 [Direct mapping] Prolactin receptor Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes FDA approved drug targets Biotech drugs Small molecule drugs Show all	GO:0004896 [cytokine receptor activity] GO:0004925 [prolactin receptor activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005886 [plasma membrane] GO:0006694 [steroid biosynthetic process] GO:0007166 [cell surface receptor signaling pathway] GO:0007171 [activation of transmembrane receptor protein tyrosine kinase activity] GO:0007566 [embryo implantation] GO:0007595 [lactation] GO:0009986 [cell surface] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0017046 [peptide hormone binding] GO:0031904 [endosome lumen] GO:0042110 [T cell activation] GO:0042803 [protein homodimerization activity] GO:0042977 [activation of JAK2 kinase activity] GO:0042978 [ornithine decarboxylase activator activity] GO:0043066 [negative regulation of apoptotic process] GO:0046872 [metal ion binding] GO:0060397 [JAK-STAT cascade involved in growth hormone signaling pathway] Show all	521 aa 58 kDa	Yes	1
PRLR-009 ENSP00000309008 ENST00000310101	P16471 [Direct mapping] Prolactin receptor Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes FDA approved drug targets Biotech drugs Small molecule drugs Show all	GO:0004896 [cytokine receptor activity] GO:0004925 [prolactin receptor activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005886 [plasma membrane] GO:0006694 [steroid biosynthetic process] GO:0007166 [cell surface receptor signaling pathway] GO:0007171 [activation of transmembrane receptor protein tyrosine kinase activity] GO:0007566 [embryo implantation] GO:0007595 [lactation] GO:0009986 [cell surface] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0017046 [peptide hormone binding] GO:0031904 [endosome lumen] GO:0042110 [T cell activation] GO:0042803 [protein homodimerization activity] GO:0042977 [activation of JAK2 kinase activity] GO:0042978 [ornithine decarboxylase activator activity] GO:0043066 [negative regulation of apoptotic process] GO:0046872 [metal ion binding] GO:0060397 [JAK-STAT cascade involved in growth hormone signaling pathway] Show all	349 aa 39.8 kDa	Yes	1
PRLR-011 ENSP00000422867 ENST00000504500	D6R9V7 [Direct mapping] Prolactin receptor Show all	MEMSAT3 predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005515 [protein binding] Show all	62 aa 6.9 kDa	Yes	0
PRLR-012 ENSP00000421864 ENST00000515839	D6RAN9 [Direct mapping] Prolactin receptor Show all	TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all		34 aa 3.7 kDa	Yes	0
PRLR-013 ENSP00000427060 ENST00000509839	D6RD41 [Direct mapping] Prolactin receptor Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005515 [protein binding] Show all	111 aa 12.6 kDa	Yes	0
PRLR-014 ENSP00000422385 ENST00000503330	D6RC67 [Direct mapping] Prolactin receptor Show all	MEMSAT3 predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005515 [protein binding] Show all	103 aa 11.8 kDa	Yes	0
PRLR-015 ENSP00000423493 ENST00000514206	D6R9P5 [Direct mapping] Prolactin receptor Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005515 [protein binding] Show all	120 aa 13.6 kDa	Yes	0
PRLR-201 ENSP00000425300 ENST00000509140	P16471 [Direct mapping] Prolactin receptor Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes FDA approved drug targets Biotech drugs Small molecule drugs Show all	GO:0004896 [cytokine receptor activity] GO:0004925 [prolactin receptor activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005886 [plasma membrane] GO:0006694 [steroid biosynthetic process] GO:0007166 [cell surface receptor signaling pathway] GO:0007171 [activation of transmembrane receptor protein tyrosine kinase activity] GO:0007566 [embryo implantation] GO:0007595 [lactation] GO:0009986 [cell surface] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0017046 [peptide hormone binding] GO:0031904 [endosome lumen] GO:0042110 [T cell activation] GO:0042803 [protein homodimerization activity] GO:0042977 [activation of JAK2 kinase activity] GO:0042978 [ornithine decarboxylase activator activity] GO:0043066 [negative regulation of apoptotic process] GO:0046872 [metal ion binding] GO:0060397 [JAK-STAT cascade involved in growth hormone signaling pathway] Show all	288 aa 32.8 kDa	Yes	1
PRLR-202 ENSP00000422935 ENST00000514088	P16471 [Direct mapping] Prolactin receptor Show all	MEMSAT3 predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes FDA approved drug targets Biotech drugs Small molecule drugs Show all	GO:0004896 [cytokine receptor activity] GO:0004925 [prolactin receptor activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005886 [plasma membrane] GO:0006694 [steroid biosynthetic process] GO:0007166 [cell surface receptor signaling pathway] GO:0007171 [activation of transmembrane receptor protein tyrosine kinase activity] GO:0007566 [embryo implantation] GO:0007595 [lactation] GO:0009986 [cell surface] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0017046 [peptide hormone binding] GO:0031904 [endosome lumen] GO:0042110 [T cell activation] GO:0042803 [protein homodimerization activity] GO:0042977 [activation of JAK2 kinase activity] GO:0042978 [ornithine decarboxylase activator activity] GO:0043066 [negative regulation of apoptotic process] GO:0046872 [metal ion binding] GO:0060397 [JAK-STAT cascade involved in growth hormone signaling pathway] Show all	268 aa 30.7 kDa	Yes	0
PRLR-203 ENSP00000441813 ENST00000542609	P16471 [Direct mapping] Prolactin receptor Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes FDA approved drug targets Biotech drugs Small molecule drugs Show all	GO:0004896 [cytokine receptor activity] GO:0004925 [prolactin receptor activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005886 [plasma membrane] GO:0006694 [steroid biosynthetic process] GO:0007166 [cell surface receptor signaling pathway] GO:0007171 [activation of transmembrane receptor protein tyrosine kinase activity] GO:0007566 [embryo implantation] GO:0007595 [lactation] GO:0009986 [cell surface] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0017046 [peptide hormone binding] GO:0031904 [endosome lumen] GO:0042110 [T cell activation] GO:0042803 [protein homodimerization activity] GO:0042977 [activation of JAK2 kinase activity] GO:0042978 [ornithine decarboxylase activator activity] GO:0043066 [negative regulation of apoptotic process] GO:0046872 [metal ion binding] GO:0060397 [JAK-STAT cascade involved in growth hormone signaling pathway] Show all	376 aa 42.6 kDa	Yes	1
PRLR-204 ENSP00000484768 ENST00000619676	P16471 [Direct mapping] Prolactin receptor Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes FDA approved drug targets Biotech drugs Small molecule drugs Show all	GO:0004896 [cytokine receptor activity] GO:0004925 [prolactin receptor activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005886 [plasma membrane] GO:0006694 [steroid biosynthetic process] GO:0007166 [cell surface receptor signaling pathway] GO:0007171 [activation of transmembrane receptor protein tyrosine kinase activity] GO:0007566 [embryo implantation] GO:0007595 [lactation] GO:0009986 [cell surface] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0017046 [peptide hormone binding] GO:0031904 [endosome lumen] GO:0042110 [T cell activation] GO:0042803 [protein homodimerization activity] GO:0042977 [activation of JAK2 kinase activity] GO:0042978 [ornithine decarboxylase activator activity] GO:0043066 [negative regulation of apoptotic process] GO:0046872 [metal ion binding] GO:0060397 [JAK-STAT cascade involved in growth hormone signaling pathway] Show all	349 aa 39.8 kDa	Yes	1
PRLR-205 ENSP00000482689 ENST00000620785	P16471 [Direct mapping] Prolactin receptor Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes FDA approved drug targets Biotech drugs Small molecule drugs Show all	GO:0004896 [cytokine receptor activity] GO:0004925 [prolactin receptor activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005886 [plasma membrane] GO:0006694 [steroid biosynthetic process] GO:0007166 [cell surface receptor signaling pathway] GO:0007171 [activation of transmembrane receptor protein tyrosine kinase activity] GO:0007566 [embryo implantation] GO:0007595 [lactation] GO:0009986 [cell surface] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0017046 [peptide hormone binding] GO:0031904 [endosome lumen] GO:0042110 [T cell activation] GO:0042803 [protein homodimerization activity] GO:0042977 [activation of JAK2 kinase activity] GO:0042978 [ornithine decarboxylase activator activity] GO:0043066 [negative regulation of apoptotic process] GO:0046872 [metal ion binding] GO:0060397 [JAK-STAT cascade involved in growth hormone signaling pathway] Show all	521 aa 58 kDa	Yes	1