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FGF1

GENERAL INFORMATION

Gene name

 FGF1

Gene description

 Fibroblast growth factor 1 (acidic)

Protein class

 Cancer-related genes
FDA approved drug targets
Predicted intracellular proteins
RAS pathway related proteins

Predicted localization

 Intracellular

Number of transcripts

 13
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (cerebral cortex, kidney)
GTEx:Group enriched (hippocampus, hypothalamus, caudate, cerebral cortex, kidney, cerebellum)
FANTOM5:Tissue enhanced (brain, hippocampus, cerebellum)

Protein evidence

 Evidence at protein level

Protein expression

 Highly selective cytoplasmic expression in endothelial cells.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA003265 , CAB017519
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (cerebral cortex, kidney)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (hippocampus, hypothalamus, caudate, cerebral cortex, kidney, cerebellum)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (brain, hippocampus, cerebellum)

GENE INFORMATION

Gene name

 FGF1 (HGNC Symbol)

Synonyms

 AFGF, ECGF, ECGF-beta, ECGFA, ECGFB, FGF-alpha, FGFA, GLIO703, HBGF1

Description

 Fibroblast growth factor 1 (acidic) (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein functions as a modifier of endothelial cell migration and proliferation, as well as an angiogenic factor. It acts as a mitogen for a variety of mesoderm- and neuroectoderm-derived cells in vitro, thus is thought to be involved in organogenesis. Multiple alternatively spliced variants encoding different isoforms have been described. [provided by RefSeq, Jan 2009]

Chromosome

 5

Cytoband

 q31.3

Chromosome location (bp)

 142592178 - 142698070

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000113578 (version 83.38)

Entrez gene

 2246

UniProt

 P05230 (UniProt - Evidence at protein level)

neXtProt

 NX_P05230

Antibodypedia

 FGF1 antibodies

PROTEIN BROWSER
«
FGF1-001
FGF1-002
FGF1-004
FGF1-006
FGF1-007
FGF1-008
FGF1-009
FGF1-010
FGF1-013
FGF1-201
FGF1-202
FGF1-203
FGF1-204
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
FGF1-001
ENSP00000352329
ENST00000359370
P05230 [Direct mapping]
Fibroblast growth factor 1
Show all
Predicted intracellular proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0001525 [angiogenesis]
GO:0005104 [fibroblast growth factor receptor binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0005938 [cell cortex]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007275 [multicellular organismal development]
GO:0007411 [axon guidance]
GO:0008083 [growth factor activity]
GO:0008201 [heparin binding]
GO:0008284 [positive regulation of cell proliferation]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0009653 [anatomical structure morphogenesis]
GO:0030335 [positive regulation of cell migration]
GO:0034605 [cellular response to heat]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0043406 [positive regulation of MAP kinase activity]
GO:0044548 [S100 protein binding]
GO:0045087 [innate immune response]
GO:0045542 [positive regulation of cholesterol biosynthetic process]
GO:0045766 [positive regulation of angiogenesis]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0051781 [positive regulation of cell division]
GO:0060681 [branch elongation involved in ureteric bud branching]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0072163 [mesonephric epithelium development]
GO:1902533 [positive regulation of intracellular signal transduction]
GO:2000544 [regulation of endothelial cell chemotaxis to fibroblast growth factor]
Show all
 155 aa
17.5 kDa 		No 0
FGF1-002
ENSP00000338548
ENST00000337706
P05230 [Direct mapping]
Fibroblast growth factor 1
Show all
Predicted intracellular proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
FDA approved drug targets
   Small molecule drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0001525 [angiogenesis]
GO:0005104 [fibroblast growth factor receptor binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0005938 [cell cortex]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007275 [multicellular organismal development]
GO:0007411 [axon guidance]
GO:0008083 [growth factor activity]
GO:0008201 [heparin binding]
GO:0008284 [positive regulation of cell proliferation]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0009653 [anatomical structure morphogenesis]
GO:0030335 [positive regulation of cell migration]
GO:0034605 [cellular response to heat]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0043406 [positive regulation of MAP kinase activity]
GO:0044548 [S100 protein binding]
GO:0045087 [innate immune response]
GO:0045542 [positive regulation of cholesterol biosynthetic process]
GO:0045766 [positive regulation of angiogenesis]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0051781 [positive regulation of cell division]
GO:0060681 [branch elongation involved in ureteric bud branching]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0072163 [mesonephric epithelium development]
GO:1902533 [positive regulation of intracellular signal transduction]
GO:2000544 [regulation of endothelial cell chemotaxis to fibroblast growth factor]
Show all
 155 aa
17.5 kDa 		No 0
FGF1-004
ENSP00000378005
ENST00000394496
C9JDC5 [Direct mapping]
Fibroblast growth factor 1
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005654 [nucleoplasm]
GO:0008083 [growth factor activity]
Show all
 58 aa
6.5 kDa 		No 0
FGF1-006
ENSP00000404742
ENST00000441680
P05230 [Direct mapping]
Fibroblast growth factor 1
Show all
Predicted intracellular proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
FDA approved drug targets
   Small molecule drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0001525 [angiogenesis]
GO:0005104 [fibroblast growth factor receptor binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0005938 [cell cortex]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007275 [multicellular organismal development]
GO:0007411 [axon guidance]
GO:0008083 [growth factor activity]
GO:0008201 [heparin binding]
GO:0008284 [positive regulation of cell proliferation]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0009653 [anatomical structure morphogenesis]
GO:0030335 [positive regulation of cell migration]
GO:0034605 [cellular response to heat]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0043406 [positive regulation of MAP kinase activity]
GO:0044548 [S100 protein binding]
GO:0045087 [innate immune response]
GO:0045542 [positive regulation of cholesterol biosynthetic process]
GO:0045766 [positive regulation of angiogenesis]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0051781 [positive regulation of cell division]
GO:0060681 [branch elongation involved in ureteric bud branching]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0072163 [mesonephric epithelium development]
GO:1902533 [positive regulation of intracellular signal transduction]
GO:2000544 [regulation of endothelial cell chemotaxis to fibroblast growth factor]
Show all
 155 aa
17.5 kDa 		No 0
FGF1-007
ENSP00000354231
ENST00000360966
P05230 [Direct mapping]
Fibroblast growth factor 1
Show all
Predicted intracellular proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0001525 [angiogenesis]
GO:0005104 [fibroblast growth factor receptor binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0005938 [cell cortex]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007275 [multicellular organismal development]
GO:0007411 [axon guidance]
GO:0008083 [growth factor activity]
GO:0008201 [heparin binding]
GO:0008284 [positive regulation of cell proliferation]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0009653 [anatomical structure morphogenesis]
GO:0030335 [positive regulation of cell migration]
GO:0034605 [cellular response to heat]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0043406 [positive regulation of MAP kinase activity]
GO:0044548 [S100 protein binding]
GO:0045087 [innate immune response]
GO:0045542 [positive regulation of cholesterol biosynthetic process]
GO:0045766 [positive regulation of angiogenesis]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0051781 [positive regulation of cell division]
GO:0060681 [branch elongation involved in ureteric bud branching]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0072163 [mesonephric epithelium development]
GO:1902533 [positive regulation of intracellular signal transduction]
GO:2000544 [regulation of endothelial cell chemotaxis to fibroblast growth factor]
Show all
 60 aa
6.7 kDa 		No 0
FGF1-008
ENSP00000367285
ENST00000378046
P05230 [Direct mapping]
Fibroblast growth factor 1
Show all
Predicted intracellular proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
FDA approved drug targets
   Small molecule drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0001525 [angiogenesis]
GO:0005104 [fibroblast growth factor receptor binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0005938 [cell cortex]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007275 [multicellular organismal development]
GO:0007411 [axon guidance]
GO:0008083 [growth factor activity]
GO:0008201 [heparin binding]
GO:0008284 [positive regulation of cell proliferation]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0009653 [anatomical structure morphogenesis]
GO:0030335 [positive regulation of cell migration]
GO:0034605 [cellular response to heat]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0043406 [positive regulation of MAP kinase activity]
GO:0044548 [S100 protein binding]
GO:0045087 [innate immune response]
GO:0045542 [positive regulation of cholesterol biosynthetic process]
GO:0045766 [positive regulation of angiogenesis]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0051781 [positive regulation of cell division]
GO:0060681 [branch elongation involved in ureteric bud branching]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0072163 [mesonephric epithelium development]
GO:1902533 [positive regulation of intracellular signal transduction]
GO:2000544 [regulation of endothelial cell chemotaxis to fibroblast growth factor]
Show all
 155 aa
17.5 kDa 		No 0
FGF1-009
ENSP00000383969
ENST00000407758
B5MCF4 [Direct mapping]
Fibroblast growth factor 1
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005654 [nucleoplasm]
GO:0008083 [growth factor activity]
Show all
 93 aa
10.4 kDa 		No 0
FGF1-010
ENSP00000396195
ENST00000419524
P05230 [Direct mapping]
Fibroblast growth factor 1
Show all
Predicted intracellular proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
FDA approved drug targets
   Small molecule drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0001525 [angiogenesis]
GO:0005104 [fibroblast growth factor receptor binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0005938 [cell cortex]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007275 [multicellular organismal development]
GO:0007411 [axon guidance]
GO:0008083 [growth factor activity]
GO:0008201 [heparin binding]
GO:0008284 [positive regulation of cell proliferation]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0009653 [anatomical structure morphogenesis]
GO:0030335 [positive regulation of cell migration]
GO:0034605 [cellular response to heat]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0043406 [positive regulation of MAP kinase activity]
GO:0044548 [S100 protein binding]
GO:0045087 [innate immune response]
GO:0045542 [positive regulation of cholesterol biosynthetic process]
GO:0045766 [positive regulation of angiogenesis]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0051781 [positive regulation of cell division]
GO:0060681 [branch elongation involved in ureteric bud branching]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0072163 [mesonephric epithelium development]
GO:1902533 [positive regulation of intracellular signal transduction]
GO:2000544 [regulation of endothelial cell chemotaxis to fibroblast growth factor]
Show all
 155 aa
17.5 kDa 		No 0
FGF1-013
ENSP00000399458
ENST00000411960
C9JUP6 [Direct mapping]
Fibroblast growth factor 1
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008083 [growth factor activity]
Show all
 41 aa
4.6 kDa 		No 0
FGF1-201
ENSP00000481868
ENST00000610990
P05230 [Direct mapping]
Fibroblast growth factor 1
Show all
Predicted intracellular proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0001525 [angiogenesis]
GO:0005104 [fibroblast growth factor receptor binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0005938 [cell cortex]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007275 [multicellular organismal development]
GO:0007411 [axon guidance]
GO:0008083 [growth factor activity]
GO:0008201 [heparin binding]
GO:0008284 [positive regulation of cell proliferation]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0009653 [anatomical structure morphogenesis]
GO:0030335 [positive regulation of cell migration]
GO:0034605 [cellular response to heat]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0043406 [positive regulation of MAP kinase activity]
GO:0044548 [S100 protein binding]
GO:0045087 [innate immune response]
GO:0045542 [positive regulation of cholesterol biosynthetic process]
GO:0045766 [positive regulation of angiogenesis]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0051781 [positive regulation of cell division]
GO:0060681 [branch elongation involved in ureteric bud branching]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0072163 [mesonephric epithelium development]
GO:1902533 [positive regulation of intracellular signal transduction]
GO:2000544 [regulation of endothelial cell chemotaxis to fibroblast growth factor]
Show all
 155 aa
17.5 kDa 		No 0
FGF1-202
ENSP00000479024
ENST00000612258
P05230 [Direct mapping]
Fibroblast growth factor 1
Show all
Predicted intracellular proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0001525 [angiogenesis]
GO:0005104 [fibroblast growth factor receptor binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0005938 [cell cortex]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007275 [multicellular organismal development]
GO:0007411 [axon guidance]
GO:0008083 [growth factor activity]
GO:0008201 [heparin binding]
GO:0008284 [positive regulation of cell proliferation]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0009653 [anatomical structure morphogenesis]
GO:0030335 [positive regulation of cell migration]
GO:0034605 [cellular response to heat]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0043406 [positive regulation of MAP kinase activity]
GO:0044548 [S100 protein binding]
GO:0045087 [innate immune response]
GO:0045542 [positive regulation of cholesterol biosynthetic process]
GO:0045766 [positive regulation of angiogenesis]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0051781 [positive regulation of cell division]
GO:0060681 [branch elongation involved in ureteric bud branching]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0072163 [mesonephric epithelium development]
GO:1902533 [positive regulation of intracellular signal transduction]
GO:2000544 [regulation of endothelial cell chemotaxis to fibroblast growth factor]
Show all
 155 aa
17.5 kDa 		No 0
FGF1-203
ENSP00000480980
ENST00000619447
P05230 [Direct mapping]
Fibroblast growth factor 1
Show all
Predicted intracellular proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0001525 [angiogenesis]
GO:0005104 [fibroblast growth factor receptor binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0005938 [cell cortex]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007275 [multicellular organismal development]
GO:0007411 [axon guidance]
GO:0008083 [growth factor activity]
GO:0008201 [heparin binding]
GO:0008284 [positive regulation of cell proliferation]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0009653 [anatomical structure morphogenesis]
GO:0030335 [positive regulation of cell migration]
GO:0034605 [cellular response to heat]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0043406 [positive regulation of MAP kinase activity]
GO:0044548 [S100 protein binding]
GO:0045087 [innate immune response]
GO:0045542 [positive regulation of cholesterol biosynthetic process]
GO:0045766 [positive regulation of angiogenesis]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0051781 [positive regulation of cell division]
GO:0060681 [branch elongation involved in ureteric bud branching]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0072163 [mesonephric epithelium development]
GO:1902533 [positive regulation of intracellular signal transduction]
GO:2000544 [regulation of endothelial cell chemotaxis to fibroblast growth factor]
Show all
 155 aa
17.5 kDa 		No 0
FGF1-204
ENSP00000480791
ENST00000621536
P05230 [Direct mapping]
Fibroblast growth factor 1
Show all
Predicted intracellular proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0001525 [angiogenesis]
GO:0001759 [organ induction]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0005104 [fibroblast growth factor receptor binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005578 [proteinaceous extracellular matrix]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005938 [cell cortex]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007275 [multicellular organismal development]
GO:0007411 [axon guidance]
GO:0008083 [growth factor activity]
GO:0008201 [heparin binding]
GO:0008283 [cell proliferation]
GO:0008284 [positive regulation of cell proliferation]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0009653 [anatomical structure morphogenesis]
GO:0030324 [lung development]
GO:0030335 [positive regulation of cell migration]
GO:0030544 [Hsp70 protein binding]
GO:0034605 [cellular response to heat]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0043406 [positive regulation of MAP kinase activity]
GO:0044548 [S100 protein binding]
GO:0045087 [innate immune response]
GO:0045542 [positive regulation of cholesterol biosynthetic process]
GO:0045766 [positive regulation of angiogenesis]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0050679 [positive regulation of epithelial cell proliferation]
GO:0051781 [positive regulation of cell division]
GO:0060681 [branch elongation involved in ureteric bud branching]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0072163 [mesonephric epithelium development]
GO:1902533 [positive regulation of intracellular signal transduction]
GO:2000544 [regulation of endothelial cell chemotaxis to fibroblast growth factor]
Show all
 155 aa
17.5 kDa 		No 0

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The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.