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The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein functions as a modifier of endothelial cell migration and proliferation, as well as an angiogenic factor. It acts as a mitogen for a variety of mesoderm- and neuroectoderm-derived cells in vitro, thus is thought to be involved in organogenesis. Multiple alternatively spliced variants encoding different isoforms have been described. [provided by RefSeq, Jan 2009]
Predicted intracellular proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000165 [MAPK cascade] GO:0000186 [activation of MAPKK activity] GO:0001525 [angiogenesis] GO:0005104 [fibroblast growth factor receptor binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005654 [nucleoplasm] GO:0005829 [cytosol] GO:0005938 [cell cortex] GO:0007165 [signal transduction] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007264 [small GTPase mediated signal transduction] GO:0007265 [Ras protein signal transduction] GO:0007275 [multicellular organismal development] GO:0007411 [axon guidance] GO:0008083 [growth factor activity] GO:0008201 [heparin binding] GO:0008284 [positive regulation of cell proliferation] GO:0008286 [insulin receptor signaling pathway] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0009653 [anatomical structure morphogenesis] GO:0030335 [positive regulation of cell migration] GO:0034605 [cellular response to heat] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0043406 [positive regulation of MAP kinase activity] GO:0044548 [S100 protein binding] GO:0045087 [innate immune response] GO:0045542 [positive regulation of cholesterol biosynthetic process] GO:0045766 [positive regulation of angiogenesis] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048015 [phosphatidylinositol-mediated signaling] GO:0051781 [positive regulation of cell division] GO:0060681 [branch elongation involved in ureteric bud branching] GO:0070374 [positive regulation of ERK1 and ERK2 cascade] GO:0072163 [mesonephric epithelium development] GO:1902533 [positive regulation of intracellular signal transduction] GO:2000544 [regulation of endothelial cell chemotaxis to fibroblast growth factor]
Predicted intracellular proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers FDA approved drug targets Small molecule drugs Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade] GO:0000186 [activation of MAPKK activity] GO:0001525 [angiogenesis] GO:0005104 [fibroblast growth factor receptor binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005654 [nucleoplasm] GO:0005829 [cytosol] GO:0005938 [cell cortex] GO:0007165 [signal transduction] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007264 [small GTPase mediated signal transduction] GO:0007265 [Ras protein signal transduction] GO:0007275 [multicellular organismal development] GO:0007411 [axon guidance] GO:0008083 [growth factor activity] GO:0008201 [heparin binding] GO:0008284 [positive regulation of cell proliferation] GO:0008286 [insulin receptor signaling pathway] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0009653 [anatomical structure morphogenesis] GO:0030335 [positive regulation of cell migration] GO:0034605 [cellular response to heat] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0043406 [positive regulation of MAP kinase activity] GO:0044548 [S100 protein binding] GO:0045087 [innate immune response] GO:0045542 [positive regulation of cholesterol biosynthetic process] GO:0045766 [positive regulation of angiogenesis] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048015 [phosphatidylinositol-mediated signaling] GO:0051781 [positive regulation of cell division] GO:0060681 [branch elongation involved in ureteric bud branching] GO:0070374 [positive regulation of ERK1 and ERK2 cascade] GO:0072163 [mesonephric epithelium development] GO:1902533 [positive regulation of intracellular signal transduction] GO:2000544 [regulation of endothelial cell chemotaxis to fibroblast growth factor]
Predicted intracellular proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers FDA approved drug targets Small molecule drugs Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade] GO:0000186 [activation of MAPKK activity] GO:0001525 [angiogenesis] GO:0005104 [fibroblast growth factor receptor binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005654 [nucleoplasm] GO:0005829 [cytosol] GO:0005938 [cell cortex] GO:0007165 [signal transduction] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007264 [small GTPase mediated signal transduction] GO:0007265 [Ras protein signal transduction] GO:0007275 [multicellular organismal development] GO:0007411 [axon guidance] GO:0008083 [growth factor activity] GO:0008201 [heparin binding] GO:0008284 [positive regulation of cell proliferation] GO:0008286 [insulin receptor signaling pathway] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0009653 [anatomical structure morphogenesis] GO:0030335 [positive regulation of cell migration] GO:0034605 [cellular response to heat] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0043406 [positive regulation of MAP kinase activity] GO:0044548 [S100 protein binding] GO:0045087 [innate immune response] GO:0045542 [positive regulation of cholesterol biosynthetic process] GO:0045766 [positive regulation of angiogenesis] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048015 [phosphatidylinositol-mediated signaling] GO:0051781 [positive regulation of cell division] GO:0060681 [branch elongation involved in ureteric bud branching] GO:0070374 [positive regulation of ERK1 and ERK2 cascade] GO:0072163 [mesonephric epithelium development] GO:1902533 [positive regulation of intracellular signal transduction] GO:2000544 [regulation of endothelial cell chemotaxis to fibroblast growth factor]
Predicted intracellular proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade] GO:0000186 [activation of MAPKK activity] GO:0001525 [angiogenesis] GO:0005104 [fibroblast growth factor receptor binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005654 [nucleoplasm] GO:0005829 [cytosol] GO:0005938 [cell cortex] GO:0007165 [signal transduction] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007264 [small GTPase mediated signal transduction] GO:0007265 [Ras protein signal transduction] GO:0007275 [multicellular organismal development] GO:0007411 [axon guidance] GO:0008083 [growth factor activity] GO:0008201 [heparin binding] GO:0008284 [positive regulation of cell proliferation] GO:0008286 [insulin receptor signaling pathway] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0009653 [anatomical structure morphogenesis] GO:0030335 [positive regulation of cell migration] GO:0034605 [cellular response to heat] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0043406 [positive regulation of MAP kinase activity] GO:0044548 [S100 protein binding] GO:0045087 [innate immune response] GO:0045542 [positive regulation of cholesterol biosynthetic process] GO:0045766 [positive regulation of angiogenesis] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048015 [phosphatidylinositol-mediated signaling] GO:0051781 [positive regulation of cell division] GO:0060681 [branch elongation involved in ureteric bud branching] GO:0070374 [positive regulation of ERK1 and ERK2 cascade] GO:0072163 [mesonephric epithelium development] GO:1902533 [positive regulation of intracellular signal transduction] GO:2000544 [regulation of endothelial cell chemotaxis to fibroblast growth factor]
Predicted intracellular proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers FDA approved drug targets Small molecule drugs Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade] GO:0000186 [activation of MAPKK activity] GO:0001525 [angiogenesis] GO:0005104 [fibroblast growth factor receptor binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005654 [nucleoplasm] GO:0005829 [cytosol] GO:0005938 [cell cortex] GO:0007165 [signal transduction] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007264 [small GTPase mediated signal transduction] GO:0007265 [Ras protein signal transduction] GO:0007275 [multicellular organismal development] GO:0007411 [axon guidance] GO:0008083 [growth factor activity] GO:0008201 [heparin binding] GO:0008284 [positive regulation of cell proliferation] GO:0008286 [insulin receptor signaling pathway] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0009653 [anatomical structure morphogenesis] GO:0030335 [positive regulation of cell migration] GO:0034605 [cellular response to heat] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0043406 [positive regulation of MAP kinase activity] GO:0044548 [S100 protein binding] GO:0045087 [innate immune response] GO:0045542 [positive regulation of cholesterol biosynthetic process] GO:0045766 [positive regulation of angiogenesis] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048015 [phosphatidylinositol-mediated signaling] GO:0051781 [positive regulation of cell division] GO:0060681 [branch elongation involved in ureteric bud branching] GO:0070374 [positive regulation of ERK1 and ERK2 cascade] GO:0072163 [mesonephric epithelium development] GO:1902533 [positive regulation of intracellular signal transduction] GO:2000544 [regulation of endothelial cell chemotaxis to fibroblast growth factor]
Predicted intracellular proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers FDA approved drug targets Small molecule drugs Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade] GO:0000186 [activation of MAPKK activity] GO:0001525 [angiogenesis] GO:0005104 [fibroblast growth factor receptor binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005654 [nucleoplasm] GO:0005829 [cytosol] GO:0005938 [cell cortex] GO:0007165 [signal transduction] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007264 [small GTPase mediated signal transduction] GO:0007265 [Ras protein signal transduction] GO:0007275 [multicellular organismal development] GO:0007411 [axon guidance] GO:0008083 [growth factor activity] GO:0008201 [heparin binding] GO:0008284 [positive regulation of cell proliferation] GO:0008286 [insulin receptor signaling pathway] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0009653 [anatomical structure morphogenesis] GO:0030335 [positive regulation of cell migration] GO:0034605 [cellular response to heat] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0043406 [positive regulation of MAP kinase activity] GO:0044548 [S100 protein binding] GO:0045087 [innate immune response] GO:0045542 [positive regulation of cholesterol biosynthetic process] GO:0045766 [positive regulation of angiogenesis] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048015 [phosphatidylinositol-mediated signaling] GO:0051781 [positive regulation of cell division] GO:0060681 [branch elongation involved in ureteric bud branching] GO:0070374 [positive regulation of ERK1 and ERK2 cascade] GO:0072163 [mesonephric epithelium development] GO:1902533 [positive regulation of intracellular signal transduction] GO:2000544 [regulation of endothelial cell chemotaxis to fibroblast growth factor]
Predicted intracellular proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade] GO:0000186 [activation of MAPKK activity] GO:0001525 [angiogenesis] GO:0005104 [fibroblast growth factor receptor binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005654 [nucleoplasm] GO:0005829 [cytosol] GO:0005938 [cell cortex] GO:0007165 [signal transduction] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007264 [small GTPase mediated signal transduction] GO:0007265 [Ras protein signal transduction] GO:0007275 [multicellular organismal development] GO:0007411 [axon guidance] GO:0008083 [growth factor activity] GO:0008201 [heparin binding] GO:0008284 [positive regulation of cell proliferation] GO:0008286 [insulin receptor signaling pathway] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0009653 [anatomical structure morphogenesis] GO:0030335 [positive regulation of cell migration] GO:0034605 [cellular response to heat] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0043406 [positive regulation of MAP kinase activity] GO:0044548 [S100 protein binding] GO:0045087 [innate immune response] GO:0045542 [positive regulation of cholesterol biosynthetic process] GO:0045766 [positive regulation of angiogenesis] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048015 [phosphatidylinositol-mediated signaling] GO:0051781 [positive regulation of cell division] GO:0060681 [branch elongation involved in ureteric bud branching] GO:0070374 [positive regulation of ERK1 and ERK2 cascade] GO:0072163 [mesonephric epithelium development] GO:1902533 [positive regulation of intracellular signal transduction] GO:2000544 [regulation of endothelial cell chemotaxis to fibroblast growth factor]
Predicted intracellular proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade] GO:0000186 [activation of MAPKK activity] GO:0001525 [angiogenesis] GO:0005104 [fibroblast growth factor receptor binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005654 [nucleoplasm] GO:0005829 [cytosol] GO:0005938 [cell cortex] GO:0007165 [signal transduction] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007264 [small GTPase mediated signal transduction] GO:0007265 [Ras protein signal transduction] GO:0007275 [multicellular organismal development] GO:0007411 [axon guidance] GO:0008083 [growth factor activity] GO:0008201 [heparin binding] GO:0008284 [positive regulation of cell proliferation] GO:0008286 [insulin receptor signaling pathway] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0009653 [anatomical structure morphogenesis] GO:0030335 [positive regulation of cell migration] GO:0034605 [cellular response to heat] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0043406 [positive regulation of MAP kinase activity] GO:0044548 [S100 protein binding] GO:0045087 [innate immune response] GO:0045542 [positive regulation of cholesterol biosynthetic process] GO:0045766 [positive regulation of angiogenesis] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048015 [phosphatidylinositol-mediated signaling] GO:0051781 [positive regulation of cell division] GO:0060681 [branch elongation involved in ureteric bud branching] GO:0070374 [positive regulation of ERK1 and ERK2 cascade] GO:0072163 [mesonephric epithelium development] GO:1902533 [positive regulation of intracellular signal transduction] GO:2000544 [regulation of endothelial cell chemotaxis to fibroblast growth factor]
Predicted intracellular proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade] GO:0000186 [activation of MAPKK activity] GO:0001525 [angiogenesis] GO:0005104 [fibroblast growth factor receptor binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005654 [nucleoplasm] GO:0005829 [cytosol] GO:0005938 [cell cortex] GO:0007165 [signal transduction] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007264 [small GTPase mediated signal transduction] GO:0007265 [Ras protein signal transduction] GO:0007275 [multicellular organismal development] GO:0007411 [axon guidance] GO:0008083 [growth factor activity] GO:0008201 [heparin binding] GO:0008284 [positive regulation of cell proliferation] GO:0008286 [insulin receptor signaling pathway] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0009653 [anatomical structure morphogenesis] GO:0030335 [positive regulation of cell migration] GO:0034605 [cellular response to heat] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0043406 [positive regulation of MAP kinase activity] GO:0044548 [S100 protein binding] GO:0045087 [innate immune response] GO:0045542 [positive regulation of cholesterol biosynthetic process] GO:0045766 [positive regulation of angiogenesis] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048015 [phosphatidylinositol-mediated signaling] GO:0051781 [positive regulation of cell division] GO:0060681 [branch elongation involved in ureteric bud branching] GO:0070374 [positive regulation of ERK1 and ERK2 cascade] GO:0072163 [mesonephric epithelium development] GO:1902533 [positive regulation of intracellular signal transduction] GO:2000544 [regulation of endothelial cell chemotaxis to fibroblast growth factor]
Predicted intracellular proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade] GO:0000186 [activation of MAPKK activity] GO:0001525 [angiogenesis] GO:0001759 [organ induction] GO:0001934 [positive regulation of protein phosphorylation] GO:0005104 [fibroblast growth factor receptor binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005578 [proteinaceous extracellular matrix] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005938 [cell cortex] GO:0007165 [signal transduction] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007264 [small GTPase mediated signal transduction] GO:0007265 [Ras protein signal transduction] GO:0007275 [multicellular organismal development] GO:0007411 [axon guidance] GO:0008083 [growth factor activity] GO:0008201 [heparin binding] GO:0008283 [cell proliferation] GO:0008284 [positive regulation of cell proliferation] GO:0008286 [insulin receptor signaling pathway] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0009653 [anatomical structure morphogenesis] GO:0030324 [lung development] GO:0030335 [positive regulation of cell migration] GO:0030544 [Hsp70 protein binding] GO:0034605 [cellular response to heat] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0043406 [positive regulation of MAP kinase activity] GO:0044548 [S100 protein binding] GO:0045087 [innate immune response] GO:0045542 [positive regulation of cholesterol biosynthetic process] GO:0045766 [positive regulation of angiogenesis] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048015 [phosphatidylinositol-mediated signaling] GO:0050679 [positive regulation of epithelial cell proliferation] GO:0051781 [positive regulation of cell division] GO:0060681 [branch elongation involved in ureteric bud branching] GO:0070374 [positive regulation of ERK1 and ERK2 cascade] GO:0072163 [mesonephric epithelium development] GO:1902533 [positive regulation of intracellular signal transduction] GO:2000544 [regulation of endothelial cell chemotaxis to fibroblast growth factor]