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NR3C1

CANCER ATLAS

Gene description

 Nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)

Protein class

 Disease related genes, FDA approved drug targets, Nuclear receptors, Plasma proteins, Predicted intracellular proteins, Transcription factors

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA004248
CAB010435

GENE INFORMATION

Gene name

 NR3C1 (HGNC Symbol)

Synonyms

 GR, GRL

Description

 Nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) (HGNC Symbol)

Entrez gene summary

 This gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues. Mutations in this gene are associated with generalized glucocorticoid resistance. Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms. Additional isoforms resulting from the use of alternate in-frame translation initiation sites have also been described, and shown to be functional, displaying diverse cytoplasm-to-nucleus trafficking patterns and distinct transcriptional activities (PMID:15866175). [provided by RefSeq, Feb 2011]

Chromosome

 5

Cytoband

 q31.3

Chromosome location (bp)

 143277931 - 143435512

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000113580 (version 83.38)

Entrez gene

 2908

UniProt

 P04150 (UniProt - Evidence at protein level)

neXtProt

 NX_P04150

Antibodypedia

 NR3C1 antibodies

PROTEIN BROWSER
«
NR3C1-001
NR3C1-002
NR3C1-003
NR3C1-004
NR3C1-005
NR3C1-006
NR3C1-007
NR3C1-008
NR3C1-009
NR3C1-010
NR3C1-013
NR3C1-201
NR3C1-202
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NR3C1-001
ENSP00000231509
ENST00000231509
P04150 [Direct mapping]
Glucocorticoid receptor
E5KQF6 [Target identity:100%; Query identity:100%]
Glucocorticoid receptor; Nuclear receptor subfamily 3, group C, member 1 (Glucocorticoid receptor), isoform CRA_a
Show all
Nuclear receptors
   Phobius predicted membrane proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0004883 [glucocorticoid receptor activity]
GO:0005496 [steroid binding]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005759 [mitochondrial matrix]
GO:0005829 [cytosol]
GO:0006111 [regulation of gluconeogenesis]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0007165 [signal transduction]
GO:0008211 [glucocorticoid metabolic process]
GO:0008270 [zinc ion binding]
GO:0010467 [gene expression]
GO:0016020 [membrane]
GO:0016568 [chromatin modification]
GO:0030325 [adrenal gland development]
GO:0031946 [regulation of glucocorticoid biosynthetic process]
GO:0038051 [glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity]
GO:0042711 [maternal behavior]
GO:0042921 [glucocorticoid receptor signaling pathway]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043402 [glucocorticoid mediated signaling pathway]
GO:0043525 [positive regulation of neuron apoptotic process]
GO:0043565 [sequence-specific DNA binding]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046983 [protein dimerization activity]
GO:0060603 [mammary gland duct morphogenesis]
GO:0071383 [cellular response to steroid hormone stimulus]
GO:1900170 [negative regulation of glucocorticoid mediated signaling pathway]
GO:1990239 [steroid hormone binding]
Show all
 778 aa
85.8 kDa 		No 0
NR3C1-002
ENSP00000377977
ENST00000394464
P04150 [Direct mapping]
Glucocorticoid receptor
F1D8N4 [Target identity:100%; Query identity:100%]
Glucocorticoid nuclear receptor variant 1
Show all
Nuclear receptors
   Phobius predicted membrane proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0004883 [glucocorticoid receptor activity]
GO:0005496 [steroid binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005759 [mitochondrial matrix]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0007165 [signal transduction]
GO:0008270 [zinc ion binding]
GO:0010467 [gene expression]
GO:0016568 [chromatin modification]
GO:0038051 [glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity]
GO:0042921 [glucocorticoid receptor signaling pathway]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043402 [glucocorticoid mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0071383 [cellular response to steroid hormone stimulus]
GO:1990239 [steroid hormone binding]
Show all
 777 aa
85.7 kDa 		No 0
NR3C1-003
ENSP00000387672
ENST00000415690
P04150 [Direct mapping]
Glucocorticoid receptor
E5KQF5 [Target identity:100%; Query identity:100%]
Glucocorticoid receptor; Nuclear receptor subfamily 3, group C, member 1 (Glucocorticoid receptor), isoform CRA_b
Show all
Nuclear receptors
   Phobius predicted membrane proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0004883 [glucocorticoid receptor activity]
GO:0005496 [steroid binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005759 [mitochondrial matrix]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0007165 [signal transduction]
GO:0008270 [zinc ion binding]
GO:0010467 [gene expression]
GO:0016568 [chromatin modification]
GO:0038051 [glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity]
GO:0042921 [glucocorticoid receptor signaling pathway]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043402 [glucocorticoid mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0071383 [cellular response to steroid hormone stimulus]
GO:1990239 [steroid hormone binding]
Show all
 742 aa
81.5 kDa 		No 0
NR3C1-004
ENSP00000424747
ENST00000510170
Q3MSN4 [Direct mapping]
Glucocorticoid receptor; Nuclear receptor subfamily 3, group C, member 1 (Glucocorticoid receptor)
Show all
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0004883 [glucocorticoid receptor activity]
GO:0005496 [steroid binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0042921 [glucocorticoid receptor signaling pathway]
GO:0043402 [glucocorticoid mediated signaling pathway]
Show all
 145 aa
15.4 kDa 		No 0
NR3C1-005
ENSP00000425313
ENST00000508760
Q3MSN4 [Direct mapping]
Glucocorticoid receptor; Nuclear receptor subfamily 3, group C, member 1 (Glucocorticoid receptor)
Show all
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0004883 [glucocorticoid receptor activity]
GO:0005496 [steroid binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0042921 [glucocorticoid receptor signaling pathway]
GO:0043402 [glucocorticoid mediated signaling pathway]
Show all
 145 aa
15.4 kDa 		No 0
NR3C1-006
ENSP00000377979
ENST00000394466
P04150 [Direct mapping]
Glucocorticoid receptor
E5KQF6 [Target identity:100%; Query identity:100%]
Glucocorticoid receptor; Nuclear receptor subfamily 3, group C, member 1 (Glucocorticoid receptor), isoform CRA_a
Show all
Nuclear receptors
   Phobius predicted membrane proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0004883 [glucocorticoid receptor activity]
GO:0005496 [steroid binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005759 [mitochondrial matrix]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0007165 [signal transduction]
GO:0008270 [zinc ion binding]
GO:0010467 [gene expression]
GO:0016568 [chromatin modification]
GO:0038051 [glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity]
GO:0042921 [glucocorticoid receptor signaling pathway]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043402 [glucocorticoid mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0071383 [cellular response to steroid hormone stimulus]
GO:1990239 [steroid hormone binding]
Show all
 778 aa
85.8 kDa 		No 0
NR3C1-007
ENSP00000427672
ENST00000503201
P04150 [Direct mapping]
Glucocorticoid receptor
F1D8N4 [Target identity:100%; Query identity:100%]
Glucocorticoid nuclear receptor variant 1
Show all
Nuclear receptors
   Phobius predicted membrane proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0004883 [glucocorticoid receptor activity]
GO:0005496 [steroid binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005759 [mitochondrial matrix]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0007165 [signal transduction]
GO:0008270 [zinc ion binding]
GO:0010467 [gene expression]
GO:0016568 [chromatin modification]
GO:0038051 [glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity]
GO:0042921 [glucocorticoid receptor signaling pathway]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043402 [glucocorticoid mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0071383 [cellular response to steroid hormone stimulus]
GO:1990239 [steroid hormone binding]
Show all
 777 aa
85.7 kDa 		No 0
NR3C1-008
ENSP00000420856
ENST00000502892
Q3MSN4 [Direct mapping]
Glucocorticoid receptor; Nuclear receptor subfamily 3, group C, member 1 (Glucocorticoid receptor)
Show all
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0004883 [glucocorticoid receptor activity]
GO:0005496 [steroid binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0042921 [glucocorticoid receptor signaling pathway]
GO:0043402 [glucocorticoid mediated signaling pathway]
Show all
 145 aa
15.4 kDa 		No 0
NR3C1-009
ENSP00000426478
ENST00000514699
Q3MSN4 [Direct mapping]
Glucocorticoid receptor; Nuclear receptor subfamily 3, group C, member 1 (Glucocorticoid receptor)
Show all
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0004883 [glucocorticoid receptor activity]
GO:0005496 [steroid binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0042921 [glucocorticoid receptor signaling pathway]
GO:0043402 [glucocorticoid mediated signaling pathway]
Show all
 145 aa
15.4 kDa 		No 0
NR3C1-010
ENSP00000422518
ENST00000504572
P04150 [Direct mapping]
Glucocorticoid receptor
E5KQF6 [Target identity:100%; Query identity:100%]
Glucocorticoid receptor; Nuclear receptor subfamily 3, group C, member 1 (Glucocorticoid receptor), isoform CRA_a
Show all
Nuclear receptors
   Phobius predicted membrane proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0004883 [glucocorticoid receptor activity]
GO:0005496 [steroid binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005759 [mitochondrial matrix]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0007165 [signal transduction]
GO:0008270 [zinc ion binding]
GO:0010467 [gene expression]
GO:0016568 [chromatin modification]
GO:0038051 [glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity]
GO:0042921 [glucocorticoid receptor signaling pathway]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043402 [glucocorticoid mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0071383 [cellular response to steroid hormone stimulus]
GO:1990239 [steroid hormone binding]
Show all
 778 aa
85.8 kDa 		No 0
NR3C1-013
ENSP00000425374
ENST00000502500
D6RDA9 [Direct mapping]
Glucocorticoid receptor
Show all
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0004883 [glucocorticoid receptor activity]
GO:0005496 [steroid binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0042921 [glucocorticoid receptor signaling pathway]
GO:0043402 [glucocorticoid mediated signaling pathway]
Show all
 144 aa
15.3 kDa 		No 0
NR3C1-201
ENSP00000343205
ENST00000343796
P04150 [Direct mapping]
Glucocorticoid receptor
F1D8N4 [Target identity:100%; Query identity:100%]
Glucocorticoid nuclear receptor variant 1
Show all
Nuclear receptors
   Phobius predicted membrane proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0004883 [glucocorticoid receptor activity]
GO:0005496 [steroid binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005759 [mitochondrial matrix]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0007165 [signal transduction]
GO:0008270 [zinc ion binding]
GO:0010467 [gene expression]
GO:0016568 [chromatin modification]
GO:0038051 [glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity]
GO:0042921 [glucocorticoid receptor signaling pathway]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043402 [glucocorticoid mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0071383 [cellular response to steroid hormone stimulus]
GO:1990239 [steroid hormone binding]
Show all
 777 aa
85.7 kDa 		No 0
NR3C1-202
ENSP00000405282
ENST00000424646
P04150 [Direct mapping]
Glucocorticoid receptor
Show all
Nuclear receptors
   Phobius predicted membrane proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0004883 [glucocorticoid receptor activity]
GO:0005496 [steroid binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005759 [mitochondrial matrix]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0007165 [signal transduction]
GO:0008270 [zinc ion binding]
GO:0010467 [gene expression]
GO:0016568 [chromatin modification]
GO:0038051 [glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity]
GO:0042921 [glucocorticoid receptor signaling pathway]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043402 [glucocorticoid mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0071383 [cellular response to steroid hormone stimulus]
GO:1990239 [steroid hormone binding]
Show all
 751 aa
82.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.