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TRIM23

GENERAL INFORMATION

Gene name

 TRIM23

Gene description

 Tripartite motif containing 23

Protein class

 Cancer-related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic and nuclear expression in most tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA039605
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 TRIM23 (HGNC Symbol)

Synonyms

 ARD1, ARFD1, RNF46

Description

 Tripartite motif containing 23 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein is also a member of the ADP ribosylation factor family of guanine nucleotide-binding family of proteins. Its carboxy terminus contains an ADP-ribosylation factor domain and a guanine nucleotide binding site, while the amino terminus contains a GTPase activating protein domain which acts on the guanine nucleotide binding site. The protein localizes to lysosomes and the Golgi apparatus. It plays a role in the formation of intracellular transport vesicles, their movement from one compartment to another, and phopholipase D activation. Three alternatively spliced transcript variants for this gene have been described. [provided by RefSeq, Jul 2008]

Chromosome

 5

Cytoband

 q12.3

Chromosome location (bp)

 65589680 - 65625975

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000113595 (version 83.38)

Entrez gene

 373

UniProt

 P36406 (UniProt - Evidence at protein level)

neXtProt

 NX_P36406

Antibodypedia

 TRIM23 antibodies

PROTEIN BROWSER
TRIM23-001
TRIM23-002
TRIM23-003
TRIM23-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TRIM23-001
ENSP00000231524
ENST00000231524
P36406 [Direct mapping]
E3 ubiquitin-protein ligase TRIM23
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Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0003924 [GTPase activity]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005765 [lysosomal membrane]
GO:0006886 [intracellular protein transport]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008047 [enzyme activator activity]
GO:0008270 [zinc ion binding]
GO:0015031 [protein transport]
GO:0016032 [viral process]
GO:0016567 [protein ubiquitination]
GO:0016874 [ligase activity]
GO:0019003 [GDP binding]
GO:0042802 [identical protein binding]
GO:0043085 [positive regulation of catalytic activity]
GO:0046872 [metal ion binding]
GO:0070062 [extracellular exosome]
Show all
 574 aa
64.1 kDa 		No 0
TRIM23-002
ENSP00000274327
ENST00000274327
P36406 [Direct mapping]
E3 ubiquitin-protein ligase TRIM23
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0003924 [GTPase activity]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005765 [lysosomal membrane]
GO:0006886 [intracellular protein transport]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008047 [enzyme activator activity]
GO:0008270 [zinc ion binding]
GO:0015031 [protein transport]
GO:0016032 [viral process]
GO:0016567 [protein ubiquitination]
GO:0016874 [ligase activity]
GO:0019003 [GDP binding]
GO:0042802 [identical protein binding]
GO:0043085 [positive regulation of catalytic activity]
GO:0046872 [metal ion binding]
GO:0070062 [extracellular exosome]
Show all
 546 aa
61.1 kDa 		No 0
TRIM23-003
ENSP00000370406
ENST00000381018
P36406 [Direct mapping]
E3 ubiquitin-protein ligase TRIM23
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0003924 [GTPase activity]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005765 [lysosomal membrane]
GO:0006886 [intracellular protein transport]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008047 [enzyme activator activity]
GO:0008270 [zinc ion binding]
GO:0015031 [protein transport]
GO:0016032 [viral process]
GO:0016567 [protein ubiquitination]
GO:0016874 [ligase activity]
GO:0019003 [GDP binding]
GO:0042802 [identical protein binding]
GO:0043085 [positive regulation of catalytic activity]
GO:0046872 [metal ion binding]
GO:0070062 [extracellular exosome]
Show all
 569 aa
63.7 kDa 		No 0
TRIM23-004
ENSP00000422144
ENST00000513794
D6R9E9 [Direct mapping]
E3 ubiquitin-protein ligase TRIM23
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
Protein evidence (Ezkurdia et al 2014)
Show all
 35 aa
3.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.