Expression of CDX1 in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Caudal type homeobox 1

Protein class

Predicted intracellular proteins, Transcription factors

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA055196

GENE INFORMATION
Gene name	CDX1
Synonyms
Description	Caudal type homeobox 1 (HGNC Symbol)
Entrez gene summary	This gene is a member of the caudal-related homeobox transcription factor gene family. The encoded DNA-binding protein regulates intestine-specific gene expression and enterocyte differentiation. It has been shown to induce expression of the intestinal alkaline phosphatase gene, and inhibit beta-catenin/T-cell factor transcriptional activity. [provided by RefSeq, Jul 2008]
Chromosome	5
Cytoband	q32
Chromosome location (bp)	150166795 - 150184558
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000113722 (version 83.38)
Entrez gene	1044
UniProt	P47902 (UniProt - Evidence at protein level)
neXtProt	NX_P47902
Antibodypedia	CDX1 antibodies

PROTEIN BROWSER

CDX1-001	CDX1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CDX1-001 ENSP00000231656 ENST00000231656	P47902 [Direct mapping] Homeobox protein CDX-1 Show all	Predicted intracellular proteins Transcription factors Helix-turn-helix domains Show all	GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding] GO:0001205 [transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding] GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0007275 [multicellular organismal development] GO:0007389 [pattern specification process] GO:0009887 [organ morphogenesis] GO:0009948 [anterior/posterior axis specification] GO:0009952 [anterior/posterior pattern specification] GO:0014807 [regulation of somitogenesis] GO:0030154 [cell differentiation] GO:0043565 [sequence-specific DNA binding] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0060349 [bone morphogenesis] Show all	265 aa 28.1 kDa	No	0
CDX1-201 ENSP00000477928 ENST00000616154	A0A087WTJ6 [Direct mapping] Homeobox protein CDX-1 Show all	Predicted intracellular proteins Show all	GO:0003677 [DNA binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0043565 [sequence-specific DNA binding] Show all	154 aa 17.4 kDa	No	0