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ZNF346

CANCER ATLAS

Gene description

 Zinc finger protein 346

Protein class

 Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA018485

GENE INFORMATION

Gene name

 ZNF346 (HGNC Symbol)

Synonyms

 JAZ, Zfp346

Description

 Zinc finger protein 346 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a nucleolar, zinc finger protein that preferentially binds to double-stranded (ds) RNA or RNA/DNA hybrids, rather than DNA alone. Mutational studies indicate that the zinc finger domains are not only essential for dsRNA binding, but are also required for its nucleolar localization. The encoded protein may be involved in cell growth and survival. It plays a role in protecting neurons by inhibiting cell cycle re-entry via stimulation of p21 gene expression. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2015]

Chromosome

 5

Cytoband

 q35.2

Chromosome location (bp)

 177022696 - 177081189

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000113761 (version 83.38)

Entrez gene

 23567

UniProt

 Q9UL40 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UL40

Antibodypedia

 ZNF346 antibodies

PROTEIN BROWSER
ZNF346-001
ZNF346-002
ZNF346-003
ZNF346-004
ZNF346-005
ZNF346-008

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ZNF346-001
ENSP00000350869
ENST00000358149
Q9UL40 [Direct mapping]
Zinc finger protein 346
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002039 [p53 binding]
GO:0003676 [nucleic acid binding]
GO:0003725 [double-stranded RNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0008270 [zinc ion binding]
GO:0019899 [enzyme binding]
GO:0044822 [poly(A) RNA binding]
GO:0046872 [metal ion binding]
GO:0072332 [intrinsic apoptotic signaling pathway by p53 class mediator]
Show all
 294 aa
32.9 kDa 		No 0
ZNF346-002
ENSP00000423515
ENST00000506693
B7Z4J8 [Direct mapping]
Zinc finger protein 346; cDNA FLJ52564, moderately similar to Zinc finger protein 346
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0008270 [zinc ion binding]
GO:0046872 [metal ion binding]
Show all
 196 aa
21.7 kDa 		No 0
ZNF346-003
ENSP00000421089
ENST00000512315
B7Z4N4 [Direct mapping]
Zinc finger protein 346; cDNA FLJ60707, moderately similar to Zinc finger protein 346
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0008270 [zinc ion binding]
GO:0046872 [metal ion binding]
Show all
 118 aa
12.8 kDa 		No 0
ZNF346-004
ENSP00000421212
ENST00000503425
Q9UL40 [Direct mapping]
Zinc finger protein 346
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002039 [p53 binding]
GO:0003676 [nucleic acid binding]
GO:0003725 [double-stranded RNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0008270 [zinc ion binding]
GO:0019899 [enzyme binding]
GO:0044822 [poly(A) RNA binding]
GO:0046872 [metal ion binding]
GO:0072332 [intrinsic apoptotic signaling pathway by p53 class mediator]
Show all
 262 aa
29.3 kDa 		No 0
ZNF346-005
ENSP00000425725
ENST00000511834
D6RJ07 [Direct mapping]
Zinc finger protein 346
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0008270 [zinc ion binding]
GO:0046872 [metal ion binding]
Show all
 310 aa
34.6 kDa 		No 0
ZNF346-008
ENSP00000424495
ENST00000503039
Q9UL40 [Direct mapping]
Zinc finger protein 346
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002039 [p53 binding]
GO:0003676 [nucleic acid binding]
GO:0003725 [double-stranded RNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0008270 [zinc ion binding]
GO:0019899 [enzyme binding]
GO:0043065 [positive regulation of apoptotic process]
GO:0044822 [poly(A) RNA binding]
GO:0046872 [metal ion binding]
GO:0072332 [intrinsic apoptotic signaling pathway by p53 class mediator]
Show all
 319 aa
35.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.