Expression of EHHADH in cancer - Summary

CANCER ATLAS

Gene description

Enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase

Protein class

Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA036401	HPA042021

GENE INFORMATION
Gene name	EHHADH (HGNC Symbol)
Synonyms	ECHD
Description	Enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a bifunctional enzyme and is one of the four enzymes of the peroxisomal beta-oxidation pathway. The N-terminal region of the encoded protein contains enoyl-CoA hydratase activity while the C-terminal region contains 3-hydroxyacyl-CoA dehydrogenase activity. Defects in this gene are a cause of peroxisomal disorders such as Zellweger syndrome. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]
Chromosome	3
Cytoband	q27.2
Chromosome location (bp)	185190624 - 185281990
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000113790 (version 83.38)
Entrez gene	1962
UniProt	Q08426 (UniProt - Evidence at protein level)
neXtProt	NX_Q08426
Antibodypedia	EHHADH antibodies

PROTEIN BROWSER

EHHADH-001	EHHADH-002	EHHADH-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
EHHADH-001 ENSP00000231887 ENST00000231887	Q08426 [Direct mapping] Peroxisomal bifunctional enzyme Enoyl-CoA hydratase/3,2-trans-enoyl-CoA isomerase 3-hydroxyacyl-CoA dehydrogenase Show all	Enzymes ENZYME proteins Oxidoreductases Lyases Isomerase SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0003857 [3-hydroxyacyl-CoA dehydrogenase activity] GO:0004165 [dodecenoyl-CoA delta-isomerase activity] GO:0004300 [enoyl-CoA hydratase activity] GO:0005102 [receptor binding] GO:0005515 [protein binding] GO:0005739 [mitochondrion] GO:0005777 [peroxisome] GO:0005829 [cytosol] GO:0006475 [internal protein amino acid acetylation] GO:0006631 [fatty acid metabolic process] GO:0006635 [fatty acid beta-oxidation] GO:0008152 [metabolic process] GO:0016491 [oxidoreductase activity] GO:0019899 [enzyme binding] GO:0055114 [oxidation-reduction process] Show all	723 aa 79.5 kDa	No	0
EHHADH-002 ENSP00000387746 ENST00000456310	Q08426 [Direct mapping] Peroxisomal bifunctional enzyme Enoyl-CoA hydratase/3,2-trans-enoyl-CoA isomerase 3-hydroxyacyl-CoA dehydrogenase Show all	Enzymes ENZYME proteins Oxidoreductases Lyases Isomerase SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0003857 [3-hydroxyacyl-CoA dehydrogenase activity] GO:0004165 [dodecenoyl-CoA delta-isomerase activity] GO:0004300 [enoyl-CoA hydratase activity] GO:0005102 [receptor binding] GO:0005515 [protein binding] GO:0005777 [peroxisome] GO:0006475 [internal protein amino acid acetylation] GO:0006631 [fatty acid metabolic process] GO:0006635 [fatty acid beta-oxidation] GO:0008152 [metabolic process] GO:0016491 [oxidoreductase activity] GO:0019899 [enzyme binding] GO:0055114 [oxidation-reduction process] Show all	627 aa 69.2 kDa	No	0
EHHADH-005 ENSP00000396798 ENST00000440662	C9JJE0 [Direct mapping] Peroxisomal bifunctional enzyme Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0008152 [metabolic process] Show all	76 aa 8.3 kDa	No	0