Expression of SMC4 in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Structural maintenance of chromosomes 4

Protein class

Plasma proteins, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA029449	CAB055509

GENE INFORMATION
Gene name	SMC4 (HGNC Symbol)
Synonyms	CAP-C, hCAP-C, SMC4L1
Description	Structural maintenance of chromosomes 4 (HGNC Symbol)
Entrez gene summary	Members of the structural maintenance of chromosomes, or SMC, family (e.g., SMC1A; MIM 300040) are critical for mitotic chromosome condensation in frogs and for DNA repair in mammals.[supplied by OMIM, Nov 2010]
Chromosome	3
Cytoband	q25.33
Chromosome location (bp)	160399274 - 160434962
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000113810 (version 83.38)
Entrez gene	10051
UniProt	Q9NTJ3 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NTJ3
Antibodypedia	SMC4 antibodies

PROTEIN BROWSER

SMC4-001	SMC4-003	SMC4-005	SMC4-006	SMC4-007	SMC4-009	SMC4-010	SMC4-011	SMC4-012	SMC4-014	SMC4-015	SMC4-016

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SMC4-001 ENSP00000349961 ENST00000357388	Q9NTJ3 [Direct mapping] Structural maintenance of chromosomes protein 4 Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000070 [mitotic sister chromatid segregation] GO:0000278 [mitotic cell cycle] GO:0000796 [condensin complex] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005694 [chromosome] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0007076 [mitotic chromosome condensation] GO:0010032 [meiotic chromosome condensation] GO:0045132 [meiotic chromosome segregation] GO:0046982 [protein heterodimerization activity] GO:0051276 [chromosome organization] GO:0051301 [cell division] GO:0051383 [kinetochore organization] Show all	1288 aa 147.2 kDa	No	0
SMC4-003 ENSP00000417964 ENST00000469762	E9PD53 [Direct mapping] Structural maintenance of chromosomes protein Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005654 [nucleoplasm] GO:0005694 [chromosome] GO:0005737 [cytoplasm] GO:0051276 [chromosome organization] Show all	1263 aa 144.5 kDa	No	0
SMC4-005 ENSP00000420121 ENST00000489573	C9JR83 [Direct mapping] Structural maintenance of chromosomes protein 4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		423 aa 48.3 kDa	No	0
SMC4-006 ENSP00000420734 ENST00000462787	Q9NTJ3 [Direct mapping] Structural maintenance of chromosomes protein 4 Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000070 [mitotic sister chromatid segregation] GO:0000278 [mitotic cell cycle] GO:0000796 [condensin complex] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005694 [chromosome] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0007076 [mitotic chromosome condensation] GO:0046982 [protein heterodimerization activity] GO:0051276 [chromosome organization] GO:0051301 [cell division] Show all	1230 aa 140.3 kDa	No	0
SMC4-007 ENSP00000341382 ENST00000344722	Q9NTJ3 [Direct mapping] Structural maintenance of chromosomes protein 4 Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000070 [mitotic sister chromatid segregation] GO:0000278 [mitotic cell cycle] GO:0000796 [condensin complex] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005694 [chromosome] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0007076 [mitotic chromosome condensation] GO:0046982 [protein heterodimerization activity] GO:0051276 [chromosome organization] GO:0051301 [cell division] Show all	1288 aa 147.2 kDa	No	0
SMC4-009 ENSP00000418820 ENST00000497311	C9IYK2 [Direct mapping] Structural maintenance of chromosomes protein 4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		173 aa 18.9 kDa	No	0
SMC4-010 ENSP00000419247 ENST00000465903	C9JWF0 [Direct mapping] Structural maintenance of chromosomes protein 4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		170 aa 18.6 kDa	No	0
SMC4-011 ENSP00000420644 ENST00000485645	C9IYK2 [Direct mapping] Structural maintenance of chromosomes protein 4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		173 aa 18.9 kDa	No	0
SMC4-012 ENSP00000417999 ENST00000472991	C9J578 [Direct mapping] Structural maintenance of chromosomes protein 4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		139 aa 16 kDa	No	0
SMC4-014 ENSP00000419360 ENST00000467468	C9JVD8 [Direct mapping] Structural maintenance of chromosomes protein 4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		119 aa 13.7 kDa	No	0
SMC4-015 ENSP00000420817 ENST00000490207	C9JJ64 [Direct mapping] Structural maintenance of chromosomes protein 4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		180 aa 19.7 kDa	No	0
SMC4-016 ENSP00000417612 ENST00000485867	C9J9E4 [Direct mapping] Structural maintenance of chromosomes protein 4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		157 aa 17.8 kDa	No	0