Tissue expression of AMOTL2 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	AMOTL2
Gene description	Angiomotin like 2
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	10
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Mixed
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Mixed
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	AMOTL2 (HGNC Symbol)
Synonyms	LCCP
Description	Angiomotin like 2 (HGNC Symbol)
Entrez gene summary	Angiomotin is a protein that binds angiostatin, a circulating inhibitor of the formation of new blood vessels (angiogenesis). Angiomotin mediates angiostatin inhibition of endothelial cell migration and tube formation in vitro. The protein encoded by this gene is related to angiomotin and is a member of the motin protein family. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]
Chromosome	3
Cytoband	q22.2
Chromosome location (bp)	134355874 - 134375479
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000114019 (version 83.38)
Entrez gene	51421
UniProt	Q9Y2J4 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y2J4
Antibodypedia	AMOTL2 antibodies

PROTEIN BROWSER

AMOTL2-001	AMOTL2-002	AMOTL2-003	AMOTL2-005	AMOTL2-009	AMOTL2-010	AMOTL2-011	AMOTL2-012	AMOTL2-013	AMOTL2-014

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
AMOTL2-001 ENSP00000249883 ENST00000249883	Q9Y2J4 [Direct mapping] Angiomotin-like protein 2 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0016055 [Wnt signaling pathway] GO:0035329 [hippo signaling] GO:0055037 [recycling endosome] Show all	780 aa 85.8 kDa	No	0
AMOTL2-002 ENSP00000425475 ENST00000513145	Q9Y2J4 [Direct mapping] Angiomotin-like protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0016055 [Wnt signaling pathway] GO:0035329 [hippo signaling] GO:0055037 [recycling endosome] Show all	777 aa 85.5 kDa	No	0
AMOTL2-003 ENSP00000422658 ENST00000506107	D6RBK2 [Direct mapping] Angiomotin-like protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		127 aa 13.9 kDa	No	0
AMOTL2-005 ENSP00000424765 ENST00000514516	Q9Y2J4 [Direct mapping] Angiomotin-like protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0005923 [bicellular tight junction] GO:0016055 [Wnt signaling pathway] GO:0016324 [apical plasma membrane] GO:0031410 [cytoplasmic vesicle] GO:0035329 [hippo signaling] GO:0042802 [identical protein binding] GO:0055037 [recycling endosome] Show all	837 aa 91.8 kDa	No	0
AMOTL2-009 ENSP00000427482 ENST00000515172	D6RIC7 [Direct mapping] Angiomotin-like protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		123 aa 13.4 kDa	No	0
AMOTL2-010 ENSP00000427184 ENST00000510560	D6RCL7 [Direct mapping] Angiomotin-like protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		198 aa 21.7 kDa	No	0
AMOTL2-011 ENSP00000424910 ENST00000504234	D6RF61 [Direct mapping] Angiomotin-like protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		151 aa 16.5 kDa	No	0
AMOTL2-012 ENSP00000427292 ENST00000505596	D6RJA4 [Direct mapping] Angiomotin-like protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		144 aa 15.7 kDa	No	0
AMOTL2-013 ENSP00000421521 ENST00000502491	D6RFG0 [Direct mapping] Angiomotin-like protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		33 aa 3.8 kDa	No	0
AMOTL2-014 ENSP00000409999 ENST00000422605	Q9Y2J4 [Direct mapping] Angiomotin-like protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0016055 [Wnt signaling pathway] GO:0035329 [hippo signaling] GO:0055037 [recycling endosome] Show all	779 aa 85.8 kDa	No	0