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OGG1

CANCER ATLAS

Gene description

 8-oxoguanine DNA glycosylase

Protein class

 Cancer-related genes, Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted secreted proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA027514
CAB047301

GENE INFORMATION

Gene name

 OGG1 (HGNC Symbol)

Synonyms

 HMMH, HOGG1, MUTM, OGH1

Description

 8-oxoguanine DNA glycosylase (HGNC Symbol)

Entrez gene summary

 This gene encodes the enzyme responsible for the excision of 8-oxoguanine, a mutagenic base byproduct which occurs as a result of exposure to reactive oxygen. The action of this enzyme includes lyase activity for chain cleavage. Alternative splicing of the C-terminal region of this gene classifies splice variants into two major groups, type 1 and type 2, depending on the last exon of the sequence. Type 1 alternative splice variants end with exon 7 and type 2 end with exon 8. All variants share the N-terminal region in common, which contains a mitochondrial targeting signal that is essential for mitochondrial localization. Many alternative splice variants for this gene have been described, but the full-length nature for every variant has not been determined. [provided by RefSeq, Aug 2008]

Chromosome

 3

Cytoband

 p25.3

Chromosome location (bp)

 9749944 - 9788219

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000114026 (version 83.38)

Entrez gene

 4968

UniProt

 O15527 (UniProt - Evidence at protein level)

neXtProt

 NX_O15527

Antibodypedia

 OGG1 antibodies

PROTEIN BROWSER
«
OGG1-001
OGG1-002
OGG1-003
OGG1-004
OGG1-005
OGG1-006
OGG1-007
OGG1-008
OGG1-010
OGG1-013
OGG1-016
OGG1-201
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
OGG1-001
ENSP00000306561
ENST00000302036
O15527 [Direct mapping]
N-glycosylase/DNA lyase 8-oxoguanine DNA glycosylase DNA-(apurinic or apyrimidinic site) lyase
E5KPM5 [Target identity:100%; Query identity:100%]
8-oxoguanine DNA glycosylase, isoform CRA_a; N-glycosylase/DNA lyase
Show all
Enzymes
   ENZYME proteins
   Lyases
   Phobius predicted secreted proteins
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Show all
GO:0002526 [acute inflammatory response]
GO:0003684 [damaged DNA binding]
GO:0003824 [catalytic activity]
GO:0004519 [endonuclease activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005739 [mitochondrion]
GO:0006281 [DNA repair]
GO:0006284 [base-excision repair]
GO:0006285 [base-excision repair, AP site formation]
GO:0006289 [nucleotide-excision repair]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0006979 [response to oxidative stress]
GO:0007568 [aging]
GO:0008017 [microtubule binding]
GO:0008534 [oxidized purine nucleobase lesion DNA N-glycosylase activity]
GO:0009314 [response to radiation]
GO:0009416 [response to light stimulus]
GO:0016363 [nuclear matrix]
GO:0016607 [nuclear speck]
GO:0019104 [DNA N-glycosylase activity]
GO:0032355 [response to estradiol]
GO:0032357 [oxidized purine DNA binding]
GO:0033158 [regulation of protein import into nucleus, translocation]
GO:0033683 [nucleotide-excision repair, DNA incision]
GO:0034039 [8-oxo-7,8-dihydroguanine DNA N-glycosylase activity]
GO:0042493 [response to drug]
GO:0043066 [negative regulation of apoptotic process]
GO:0043234 [protein complex]
GO:0045007 [depurination]
GO:0045008 [depyrimidination]
GO:0045471 [response to ethanol]
GO:0051593 [response to folic acid]
GO:0071276 [cellular response to cadmium ion]
GO:1901291 [negative regulation of double-strand break repair via single-strand annealing]
Show all
 424 aa
47.2 kDa 		No 0
OGG1-002
ENSP00000342851
ENST00000344629
O15527 [Direct mapping]
N-glycosylase/DNA lyase 8-oxoguanine DNA glycosylase DNA-(apurinic or apyrimidinic site) lyase
E5KPN1 [Target identity:100%; Query identity:100%]
8-oxoguanine DNA glycosylase, isoform CRA_f; N-glycosylase/DNA lyase
Show all
Enzymes
   ENZYME proteins
   Lyases
   Phobius predicted secreted proteins
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Show all
GO:0003684 [damaged DNA binding]
GO:0003824 [catalytic activity]
GO:0004519 [endonuclease activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005739 [mitochondrion]
GO:0006281 [DNA repair]
GO:0006284 [base-excision repair]
GO:0006285 [base-excision repair, AP site formation]
GO:0006289 [nucleotide-excision repair]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0006979 [response to oxidative stress]
GO:0008534 [oxidized purine nucleobase lesion DNA N-glycosylase activity]
GO:0009314 [response to radiation]
GO:0016363 [nuclear matrix]
GO:0016607 [nuclear speck]
GO:0032357 [oxidized purine DNA binding]
GO:0033158 [regulation of protein import into nucleus, translocation]
GO:0033683 [nucleotide-excision repair, DNA incision]
GO:0034039 [8-oxo-7,8-dihydroguanine DNA N-glycosylase activity]
GO:0043234 [protein complex]
GO:0045007 [depurination]
GO:0045008 [depyrimidination]
GO:1901291 [negative regulation of double-strand break repair via single-strand annealing]
Show all
 345 aa
38.8 kDa 		No 0
OGG1-003
ENSP00000305584
ENST00000302003
O15527 [Direct mapping]
N-glycosylase/DNA lyase 8-oxoguanine DNA glycosylase DNA-(apurinic or apyrimidinic site) lyase
E5KPN0 [Target identity:100%; Query identity:100%]
8-oxoguanine DNA glycosylase, isoform CRA_d; N-glycosylase/DNA lyase
Show all
Enzymes
   ENZYME proteins
   Lyases
   Phobius predicted secreted proteins
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Show all
GO:0003684 [damaged DNA binding]
GO:0003824 [catalytic activity]
GO:0004519 [endonuclease activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005739 [mitochondrion]
GO:0006281 [DNA repair]
GO:0006284 [base-excision repair]
GO:0006285 [base-excision repair, AP site formation]
GO:0006289 [nucleotide-excision repair]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0006979 [response to oxidative stress]
GO:0008534 [oxidized purine nucleobase lesion DNA N-glycosylase activity]
GO:0009314 [response to radiation]
GO:0016363 [nuclear matrix]
GO:0016607 [nuclear speck]
GO:0032357 [oxidized purine DNA binding]
GO:0033158 [regulation of protein import into nucleus, translocation]
GO:0033683 [nucleotide-excision repair, DNA incision]
GO:0034039 [8-oxo-7,8-dihydroguanine DNA N-glycosylase activity]
GO:0043234 [protein complex]
GO:0045007 [depurination]
GO:0045008 [depyrimidination]
GO:1901291 [negative regulation of double-strand break repair via single-strand annealing]
Show all
 410 aa
45.8 kDa 		No 0
OGG1-004
ENSP00000344899
ENST00000352937
H7BXZ1 [Direct mapping]
N-glycosylase/DNA lyase
Show all
Predicted intracellular proteins
Show all
GO:0003684 [damaged DNA binding]
GO:0003824 [catalytic activity]
GO:0006281 [DNA repair]
GO:0006284 [base-excision repair]
GO:0006289 [nucleotide-excision repair]
GO:0008534 [oxidized purine nucleobase lesion DNA N-glycosylase activity]
Show all
 263 aa
29 kDa 		No 0
OGG1-005
ENSP00000373337
ENST00000383826
O15527 [Direct mapping]
N-glycosylase/DNA lyase 8-oxoguanine DNA glycosylase DNA-(apurinic or apyrimidinic site) lyase
E5KPM8 [Target identity:100%; Query identity:100%]
8-oxoguanine DNA glycosylase, isoform CRA_e; N-glycosylase/DNA lyase
Show all
Enzymes
   ENZYME proteins
   Lyases
   Phobius predicted secreted proteins
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Show all
GO:0003684 [damaged DNA binding]
GO:0003824 [catalytic activity]
GO:0004519 [endonuclease activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005739 [mitochondrion]
GO:0006281 [DNA repair]
GO:0006284 [base-excision repair]
GO:0006285 [base-excision repair, AP site formation]
GO:0006289 [nucleotide-excision repair]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0006979 [response to oxidative stress]
GO:0008534 [oxidized purine nucleobase lesion DNA N-glycosylase activity]
GO:0009314 [response to radiation]
GO:0016363 [nuclear matrix]
GO:0016607 [nuclear speck]
GO:0032357 [oxidized purine DNA binding]
GO:0033158 [regulation of protein import into nucleus, translocation]
GO:0033683 [nucleotide-excision repair, DNA incision]
GO:0034039 [8-oxo-7,8-dihydroguanine DNA N-glycosylase activity]
GO:0043234 [protein complex]
GO:0045007 [depurination]
GO:0045008 [depyrimidination]
GO:1901291 [negative regulation of double-strand break repair via single-strand annealing]
Show all
 195 aa
22.2 kDa 		No 0
OGG1-006
ENSP00000305527
ENST00000302008
O15527 [Direct mapping]
N-glycosylase/DNA lyase 8-oxoguanine DNA glycosylase DNA-(apurinic or apyrimidinic site) lyase
E5KPM7 [Target identity:100%; Query identity:100%]
8-oxoguanine DNA glycosylase, isoform CRA_j; N-glycosylase/DNA lyase
Show all
Enzymes
   ENZYME proteins
   Lyases
   Phobius predicted secreted proteins
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Show all
GO:0003684 [damaged DNA binding]
GO:0003824 [catalytic activity]
GO:0004519 [endonuclease activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005739 [mitochondrion]
GO:0006281 [DNA repair]
GO:0006284 [base-excision repair]
GO:0006285 [base-excision repair, AP site formation]
GO:0006289 [nucleotide-excision repair]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0006979 [response to oxidative stress]
GO:0008534 [oxidized purine nucleobase lesion DNA N-glycosylase activity]
GO:0009314 [response to radiation]
GO:0016363 [nuclear matrix]
GO:0016607 [nuclear speck]
GO:0032357 [oxidized purine DNA binding]
GO:0033158 [regulation of protein import into nucleus, translocation]
GO:0033683 [nucleotide-excision repair, DNA incision]
GO:0034039 [8-oxo-7,8-dihydroguanine DNA N-glycosylase activity]
GO:0043234 [protein complex]
GO:0045007 [depurination]
GO:0045008 [depyrimidination]
GO:1901291 [negative regulation of double-strand break repair via single-strand annealing]
Show all
 356 aa
40.1 kDa 		No 0
OGG1-007
ENSP00000345520
ENST00000339511
O15527 [Direct mapping]
N-glycosylase/DNA lyase 8-oxoguanine DNA glycosylase DNA-(apurinic or apyrimidinic site) lyase
Show all
Enzymes
   ENZYME proteins
   Lyases
   Phobius predicted secreted proteins
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Show all
GO:0003684 [damaged DNA binding]
GO:0003824 [catalytic activity]
GO:0004519 [endonuclease activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005739 [mitochondrion]
GO:0006281 [DNA repair]
GO:0006284 [base-excision repair]
GO:0006285 [base-excision repair, AP site formation]
GO:0006289 [nucleotide-excision repair]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0006979 [response to oxidative stress]
GO:0008534 [oxidized purine nucleobase lesion DNA N-glycosylase activity]
GO:0009314 [response to radiation]
GO:0016363 [nuclear matrix]
GO:0016607 [nuclear speck]
GO:0032357 [oxidized purine DNA binding]
GO:0033158 [regulation of protein import into nucleus, translocation]
GO:0033683 [nucleotide-excision repair, DNA incision]
GO:0034039 [8-oxo-7,8-dihydroguanine DNA N-glycosylase activity]
GO:0043234 [protein complex]
GO:0045007 [depurination]
GO:0045008 [depyrimidination]
GO:1901291 [negative regulation of double-strand break repair via single-strand annealing]
Show all
 324 aa
36.4 kDa 		No 0
OGG1-008
ENSP00000403598
ENST00000449570
O15527 [Direct mapping]
N-glycosylase/DNA lyase 8-oxoguanine DNA glycosylase DNA-(apurinic or apyrimidinic site) lyase
E5KPM9 [Target identity:100%; Query identity:100%]
8-oxoguanine DNA glycosylase, isoform CRA_h; N-glycosylase/DNA lyase
Show all
Enzymes
   ENZYME proteins
   Lyases
   Phobius predicted secreted proteins
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Show all
GO:0003684 [damaged DNA binding]
GO:0003824 [catalytic activity]
GO:0004519 [endonuclease activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005739 [mitochondrion]
GO:0006281 [DNA repair]
GO:0006284 [base-excision repair]
GO:0006285 [base-excision repair, AP site formation]
GO:0006289 [nucleotide-excision repair]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0006979 [response to oxidative stress]
GO:0008534 [oxidized purine nucleobase lesion DNA N-glycosylase activity]
GO:0009314 [response to radiation]
GO:0016363 [nuclear matrix]
GO:0016607 [nuclear speck]
GO:0032357 [oxidized purine DNA binding]
GO:0033158 [regulation of protein import into nucleus, translocation]
GO:0033683 [nucleotide-excision repair, DNA incision]
GO:0034039 [8-oxo-7,8-dihydroguanine DNA N-glycosylase activity]
GO:0043234 [protein complex]
GO:0045007 [depurination]
GO:0045008 [depyrimidination]
GO:1901291 [negative regulation of double-strand break repair via single-strand annealing]
Show all
 322 aa
36.1 kDa 		No 0
OGG1-010
ENSP00000402713
ENST00000416333
H7C1V7 [Direct mapping]
N-glycosylase/DNA lyase
Show all
Predicted intracellular proteins
Show all
GO:0003824 [catalytic activity]
GO:0006281 [DNA repair]
Show all
 132 aa
14.6 kDa 		No 0
OGG1-013
ENSP00000390337
ENST00000441094
H7BZM3 [Direct mapping]
N-glycosylase/DNA lyase
Show all
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
Show all
GO:0003824 [catalytic activity]
GO:0006281 [DNA repair]
GO:0006284 [base-excision repair]
Show all
 222 aa
24.4 kDa 		Yes 0
OGG1-016
ENSP00000399810
ENST00000426518
H7C1D7 [Direct mapping]
N-glycosylase/DNA lyase
Show all
Predicted intracellular proteins
Show all
GO:0003684 [damaged DNA binding]
GO:0003824 [catalytic activity]
GO:0006281 [DNA repair]
GO:0006284 [base-excision repair]
GO:0006289 [nucleotide-excision repair]
GO:0008534 [oxidized purine nucleobase lesion DNA N-glycosylase activity]
Show all
 128 aa
14.3 kDa 		No 0
OGG1-201
ENSP00000303132
ENST00000349503
O15527 [Direct mapping]
N-glycosylase/DNA lyase 8-oxoguanine DNA glycosylase DNA-(apurinic or apyrimidinic site) lyase
E5KPM6 [Target identity:100%; Query identity:100%]
8-oxoguanine DNA glycosylase, isoform CRA_k; N-glycosylase/DNA lyase
Show all
Enzymes
   ENZYME proteins
   Lyases
   Phobius predicted secreted proteins
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Show all
GO:0003684 [damaged DNA binding]
GO:0003824 [catalytic activity]
GO:0004519 [endonuclease activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005739 [mitochondrion]
GO:0006281 [DNA repair]
GO:0006284 [base-excision repair]
GO:0006285 [base-excision repair, AP site formation]
GO:0006289 [nucleotide-excision repair]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0006979 [response to oxidative stress]
GO:0008534 [oxidized purine nucleobase lesion DNA N-glycosylase activity]
GO:0009314 [response to radiation]
GO:0016363 [nuclear matrix]
GO:0016607 [nuclear speck]
GO:0032357 [oxidized purine DNA binding]
GO:0033158 [regulation of protein import into nucleus, translocation]
GO:0033683 [nucleotide-excision repair, DNA incision]
GO:0034039 [8-oxo-7,8-dihydroguanine DNA N-glycosylase activity]
GO:0043234 [protein complex]
GO:0045007 [depurination]
GO:0045008 [depyrimidination]
GO:1901291 [negative regulation of double-strand break repair via single-strand annealing]
Show all
 357 aa
39.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.