Cell atlas - KPNA1 - The Human Protein Atlas

GENERAL INFORMATION
Gene name	KPNA1
Gene description	Karyopherin alpha 1 (importin alpha 5)
Protein class	Predicted intracellular proteins Transporters
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleus. In addition localized to the cytosol.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleus (validated)
Additional location	In addition localized to the Cytosol (validated)

DATA RELIABILITY
Reliability score	Validated based on 2 antibodies. HPA053627 , HPA063426
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ASSAYS

RNA expression

Human cells

Mouse cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleus. In addition localized to the cytosol.

Main location

Nucleus (validated)

Additional location

Cytosol (validated)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location
HPA053627	MCF7	Nucleoplasm
HPA053627	PC-3	Nucleoplasm
HPA053627	PC-3	Cytosol
HPA053627	U-2 OS	Nucleoplasm
HPA053627	U-2 OS	Cytosol
HPA063426	PC-3	Nucleus
HPA063426	PC-3	Cytosol
HPA063426	U-2 OS	Nucleus
HPA063426	U-2 OS	Cytosol

MOUSE CELLS

Main location

Not available

Mouse gene

ENSMUSG00000022905 (version 83)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location
	HPA053627	NIH 3T3	No staining

GENE INFORMATION
Gene name	KPNA1 (HGNC Symbol)
Synonyms	IPOA5, NPI-1, RCH2, SRP1
Description	Karyopherin alpha 1 (importin alpha 5) (HGNC Symbol)
Entrez gene summary	The transport of molecules between the nucleus and the cytoplasm in eukaryotic cells is mediated by the nuclear pore complex (NPC), which consists of 60-100 proteins. Small molecules (up to 70 kD) can pass through the nuclear pore by nonselective diffusion while larger molecules are transported by an active process. The protein encoded by this gene belongs to the importin alpha family, and is involved in nuclear protein import. This protein interacts with the recombination activating gene 1 (RAG1) protein and is a putative substrate of the RAG1 ubiquitin ligase. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]
Chromosome	3
Cytoband	q21.1
Chromosome location (bp)	122421949 - 122514945
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000114030 (version 83.38)
Entrez gene	3836
UniProt	P52294 (UniProt - Evidence at protein level)
neXtProt	NX_P52294
Antibodypedia	KPNA1 antibodies

PROTEIN BROWSER

KPNA1-001	KPNA1-006	KPNA1-008	KPNA1-009	KPNA1-010

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
KPNA1-001 ENSP00000343701 ENST00000344337	P52294 [Direct mapping] Importin subunit alpha-5 Importin subunit alpha-5, N-terminally processed Show all	Transporters Transporter channels and pores THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000018 [regulation of DNA recombination] GO:0005488 [binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005643 [nuclear pore] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006309 [apoptotic DNA fragmentation] GO:0006606 [protein import into nucleus] GO:0006607 [NLS-bearing protein import into nucleus] GO:0006915 [apoptotic process] GO:0006921 [cellular component disassembly involved in execution phase of apoptosis] GO:0008139 [nuclear localization sequence binding] GO:0008565 [protein transporter activity] GO:0012501 [programmed cell death] GO:0016032 [viral process] GO:0019048 [modulation by virus of host morphology or physiology] GO:0019054 [modulation by virus of host process] GO:0019058 [viral life cycle] GO:0019221 [cytokine-mediated signaling pathway] GO:0030425 [dendrite] GO:0042307 [positive regulation of protein import into nucleus] GO:0075733 [intracellular transport of virus] Show all	538 aa 60.2 kDa	No	0
KPNA1-006 ENSP00000419890 ENST00000465882	C9JYI4 [Direct mapping] Importin subunit alpha-5 Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005488 [binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006606 [protein import into nucleus] GO:0008565 [protein transporter activity] Show all	328 aa 36.8 kDa	No	0
KPNA1-008 ENSP00000419257 ENST00000493510	C9JWD9 [Direct mapping] Importin subunit alpha-5 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005488 [binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006606 [protein import into nucleus] GO:0008565 [protein transporter activity] Show all	174 aa 19.9 kDa	No	0
KPNA1-009 ENSP00000417166 ENST00000482287	C9J4U1 [Direct mapping] Importin subunit alpha-5 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005488 [binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006606 [protein import into nucleus] GO:0008565 [protein transporter activity] Show all	215 aa 24.4 kDa	No	0
KPNA1-010 ENSP00000417319 ENST00000476916	C9J352 [Direct mapping] Importin subunit alpha-5 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005488 [binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006606 [protein import into nucleus] GO:0008565 [protein transporter activity] Show all	169 aa 19.4 kDa	No	0