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UBE3A

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GENERAL INFORMATION

Gene name

 UBE3A

Gene description

 Ubiquitin protein ligase E3A

Protein class

 Disease related genes
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 20
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the nucleoplasm. In addition localized to the cytosol.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleoplasm (approved)

Additional location

 In addition localized to the Cytosol (approved)

DATA RELIABILITY

Reliability score

 Approved based on 1 antibody.
HPA039410
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the nucleoplasm. In addition localized to the cytosol.

Main location

 Nucleoplasm (approved)

Additional location

 Cytosol (approved)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA039410 A-431 Nucleoplasm
Cytosol
HPA039410 U-2 OS Nucleoplasm
Cytosol
HPA039410 U-251 MG Nucleoplasm
Cytosol

GENE INFORMATION

Gene name

 UBE3A (HGNC Symbol)

Synonyms

 ANCR, AS, E6-AP, EPVE6AP, FLJ26981, HPVE6A

Description

 Ubiquitin protein ligase E3A (HGNC Symbol)

Entrez gene summary

 This gene encodes an E3 ubiquitin-protein ligase, part of the ubiquitin protein degradation system. This imprinted gene is maternally expressed in brain and biallelically expressed in other tissues. Maternally inherited deletion of this gene causes Angelman Syndrome, characterized by severe motor and intellectual retardation, ataxia, hypotonia, epilepsy, absence of speech, and characteristic facies. The protein also interacts with the E6 protein of human papillomavirus types 16 and 18, resulting in ubiquitination and proteolysis of tumor protein p53. Alternative splicing of this gene results in three transcript variants encoding three isoforms with different N-termini. Additional transcript variants have been described, but their full length nature has not been determined. [provided by RefSeq, Jul 2008]

Chromosome

 15

Cytoband

 q11.2

Chromosome location (bp)

 25333728 - 25439056

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000114062 (version 83.38)

Entrez gene

 7337

UniProt

 Q05086 (UniProt - Evidence at protein level)

neXtProt

 NX_Q05086

Antibodypedia

 UBE3A antibodies

PROTEIN BROWSER
«
UBE3A-001
UBE3A-002
UBE3A-003
UBE3A-004
UBE3A-005
UBE3A-007
UBE3A-008
UBE3A-009
UBE3A-010
UBE3A-011
UBE3A-012
UBE3A-013
UBE3A-014
UBE3A-016
UBE3A-017
UBE3A-018
UBE3A-019
UBE3A-022
UBE3A-023
UBE3A-201
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
UBE3A-001
ENSP00000481796
ENST00000614096
Q05086 [Direct mapping]
Ubiquitin-protein ligase E3A
Show all
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000502 [proteasome complex]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006508 [proteolysis]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0007420 [brain development]
GO:0016032 [viral process]
GO:0016874 [ligase activity]
GO:0031398 [positive regulation of protein ubiquitination]
GO:0042752 [regulation of circadian rhythm]
GO:0046872 [metal ion binding]
GO:0048511 [rhythmic process]
GO:0051865 [protein autoubiquitination]
GO:0061630 [ubiquitin protein ligase activity]
GO:0070936 [protein K48-linked ubiquitination]
GO:2000058 [regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process]
Show all
 872 aa
100.1 kDa 		No 0
UBE3A-002
ENSP00000457771
ENST00000566215
Q05086 [Direct mapping]
Ubiquitin-protein ligase E3A
Q9H2G0 [Target identity:100%; Query identity:100%]
CTCL tumor antigen se37-2; Ubiquitin protein ligase E3A (Human papilloma virus E6-associated protein, Angelman syndrome), isoform CRA_b; cDNA FLJ77551, highly similar to Homo sapiens ubiquitin protein ligase E3A (human papilloma virus E6-associated protein, Angelman syndrome) (UBE3A), transcript variant 1, mRNA
Show all
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000502 [proteasome complex]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006508 [proteolysis]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0007420 [brain development]
GO:0016032 [viral process]
GO:0016874 [ligase activity]
GO:0031398 [positive regulation of protein ubiquitination]
GO:0042752 [regulation of circadian rhythm]
GO:0046872 [metal ion binding]
GO:0048511 [rhythmic process]
GO:0051865 [protein autoubiquitination]
GO:0061630 [ubiquitin protein ligase activity]
GO:0070936 [protein K48-linked ubiquitination]
GO:2000058 [regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process]
Show all
 852 aa
98 kDa 		No 0
UBE3A-003
ENSP00000381045
ENST00000397954
Q05086 [Direct mapping]
Ubiquitin-protein ligase E3A
Show all
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000502 [proteasome complex]
GO:0001541 [ovarian follicle development]
GO:0003713 [transcription coactivator activity]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006508 [proteolysis]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0007420 [brain development]
GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling]
GO:0016032 [viral process]
GO:0016567 [protein ubiquitination]
GO:0016874 [ligase activity]
GO:0030521 [androgen receptor signaling pathway]
GO:0031398 [positive regulation of protein ubiquitination]
GO:0035037 [sperm entry]
GO:0042752 [regulation of circadian rhythm]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
GO:0048511 [rhythmic process]
GO:0051865 [protein autoubiquitination]
GO:0060736 [prostate gland growth]
GO:0061630 [ubiquitin protein ligase activity]
GO:0070936 [protein K48-linked ubiquitination]
GO:2000058 [regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process]
Show all
 875 aa
100.7 kDa 		No 0
UBE3A-004
ENSP00000401265
ENST00000428984
Q05086 [Direct mapping]
Ubiquitin-protein ligase E3A
Q9H2G0 [Target identity:100%; Query identity:100%]
CTCL tumor antigen se37-2; Ubiquitin protein ligase E3A (Human papilloma virus E6-associated protein, Angelman syndrome), isoform CRA_b; cDNA FLJ77551, highly similar to Homo sapiens ubiquitin protein ligase E3A (human papilloma virus E6-associated protein, Angelman syndrome) (UBE3A), transcript variant 1, mRNA
Show all
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000502 [proteasome complex]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006508 [proteolysis]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0007420 [brain development]
GO:0016032 [viral process]
GO:0016874 [ligase activity]
GO:0031398 [positive regulation of protein ubiquitination]
GO:0042752 [regulation of circadian rhythm]
GO:0046872 [metal ion binding]
GO:0048511 [rhythmic process]
GO:0051865 [protein autoubiquitination]
GO:0061630 [ubiquitin protein ligase activity]
GO:0070936 [protein K48-linked ubiquitination]
GO:2000058 [regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process]
Show all
 852 aa
98 kDa 		No 0
UBE3A-005
ENSP00000487217
ENST00000625778
A0A0D9SG77 [Direct mapping]
Ubiquitin-protein ligase E3A
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004842 [ubiquitin-protein transferase activity]
GO:0016567 [protein ubiquitination]
GO:0016874 [ligase activity]
Show all
 765 aa
88.1 kDa 		No 1
UBE3A-007
ENSP00000486349
ENST00000630424
Q05086 [Direct mapping]
Ubiquitin-protein ligase E3A
Q9H2G0 [Target identity:100%; Query identity:100%]
CTCL tumor antigen se37-2; Ubiquitin protein ligase E3A (Human papilloma virus E6-associated protein, Angelman syndrome), isoform CRA_b; cDNA FLJ77551, highly similar to Homo sapiens ubiquitin protein ligase E3A (human papilloma virus E6-associated protein, Angelman syndrome) (UBE3A), transcript variant 1, mRNA
Show all
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000502 [proteasome complex]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006508 [proteolysis]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0007420 [brain development]
GO:0016032 [viral process]
GO:0016874 [ligase activity]
GO:0031398 [positive regulation of protein ubiquitination]
GO:0042752 [regulation of circadian rhythm]
GO:0046872 [metal ion binding]
GO:0048511 [rhythmic process]
GO:0051865 [protein autoubiquitination]
GO:0061630 [ubiquitin protein ligase activity]
GO:0070936 [protein K48-linked ubiquitination]
GO:2000058 [regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process]
Show all
 852 aa
98 kDa 		No 0
UBE3A-008
ENSP00000232165
ENST00000232165
Q05086 [Direct mapping]
Ubiquitin-protein ligase E3A
Q9H2G0 [Target identity:100%; Query identity:100%]
CTCL tumor antigen se37-2; Ubiquitin protein ligase E3A (Human papilloma virus E6-associated protein, Angelman syndrome), isoform CRA_b; cDNA FLJ77551, highly similar to Homo sapiens ubiquitin protein ligase E3A (human papilloma virus E6-associated protein, Angelman syndrome) (UBE3A), transcript variant 1, mRNA
Show all
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000502 [proteasome complex]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006508 [proteolysis]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0007420 [brain development]
GO:0016032 [viral process]
GO:0016874 [ligase activity]
GO:0031398 [positive regulation of protein ubiquitination]
GO:0042752 [regulation of circadian rhythm]
GO:0046872 [metal ion binding]
GO:0048511 [rhythmic process]
GO:0051865 [protein autoubiquitination]
GO:0061630 [ubiquitin protein ligase activity]
GO:0070936 [protein K48-linked ubiquitination]
GO:2000058 [regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process]
Show all
 852 aa
98 kDa 		No 0
UBE3A-009
ENSP00000487550
ENST00000630607
A0A0D9SGJ0 [Direct mapping]
Ubiquitin-protein ligase E3A
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 62 aa
7 kDa 		No 0
UBE3A-010
ENSP00000487552
ENST00000628267
A0A0D9SGJ1 [Direct mapping]
Ubiquitin-protein ligase E3A
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 50 aa
5.6 kDa 		No 0
UBE3A-011
ENSP00000486601
ENST00000625681
A0A0D9SFH3 [Direct mapping]
Ubiquitin-protein ligase E3A
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 14 aa
1.5 kDa 		No 0
UBE3A-012
ENSP00000486388
ENST00000628733
A0A0D9SF91 [Direct mapping]
Ubiquitin-protein ligase E3A
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 187 aa
21.1 kDa 		No 0
UBE3A-013
ENSP00000486900
ENST00000629252
A0A0D9SFU3 [Direct mapping]
Ubiquitin-protein ligase E3A
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 49 aa
5.5 kDa 		No 0
UBE3A-014
ENSP00000485958
ENST00000630907
A0A0D9SES7 [Direct mapping]
Ubiquitin-protein ligase E3A
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 148 aa
16.6 kDa 		No 0
UBE3A-016
ENSP00000487148
ENST00000629886
A0A0D9SG54 [Direct mapping]
Ubiquitin-protein ligase E3A
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 77 aa
8.5 kDa 		No 0
UBE3A-017
ENSP00000486066
ENST00000626589
A0A0G2JQQ5 [Direct mapping]
Ubiquitin-protein ligase E3A
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 8 aa
0.9 kDa 		No 0
UBE3A-018
ENSP00000485732
ENST00000628890
A0A0D9SEJ2 [Direct mapping]
Ubiquitin-protein ligase E3A
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 40 aa
4.6 kDa 		No 0
UBE3A-019
ENSP00000487534
ENST00000626068
A0A0D9SGI3 [Direct mapping]
Ubiquitin-protein ligase E3A
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 237 aa
26.5 kDa 		No 0
UBE3A-022
ENSP00000473822
ENST00000604860
S4R306 [Direct mapping]
Ubiquitin-protein ligase E3A
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004842 [ubiquitin-protein transferase activity]
GO:0016567 [protein ubiquitination]
GO:0016874 [ligase activity]
Show all
 189 aa
21.9 kDa 		No 0
UBE3A-023
ENSP00000487178
ENST00000626176
A0A0D9SG63 [Direct mapping]
Ubiquitin-protein ligase E3A
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004842 [ubiquitin-protein transferase activity]
GO:0016567 [protein ubiquitination]
GO:0016874 [ligase activity]
Show all
 143 aa
16.3 kDa 		No 0
UBE3A-201
ENSP00000411258
ENST00000438097
Q05086 [Direct mapping]
Ubiquitin-protein ligase E3A
Q9H2G0 [Target identity:100%; Query identity:100%]
CTCL tumor antigen se37-2; Ubiquitin protein ligase E3A (Human papilloma virus E6-associated protein, Angelman syndrome), isoform CRA_b; cDNA FLJ77551, highly similar to Homo sapiens ubiquitin protein ligase E3A (human papilloma virus E6-associated protein, Angelman syndrome) (UBE3A), transcript variant 1, mRNA
Show all
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000502 [proteasome complex]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006508 [proteolysis]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0007420 [brain development]
GO:0016032 [viral process]
GO:0016874 [ligase activity]
GO:0031398 [positive regulation of protein ubiquitination]
GO:0042752 [regulation of circadian rhythm]
GO:0046872 [metal ion binding]
GO:0048511 [rhythmic process]
GO:0051865 [protein autoubiquitination]
GO:0061630 [ubiquitin protein ligase activity]
GO:0070936 [protein K48-linked ubiquitination]
GO:2000058 [regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process]
Show all
 852 aa
98 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.