Tissue expression of SERPINI2 - Summary

GENERAL INFORMATION
Gene name	SERPINI2
Gene description	Serpin peptidase inhibitor, clade I (pancpin), member 2
Protein class	Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enriched (pancreas)
GTEx:	Tissue enriched (pancreas)
FANTOM5:	Tissue enriched (pancreas)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (pancreas)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (pancreas)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (pancreas)

GENE INFORMATION
Gene name	SERPINI2 (HGNC Symbol)
Synonyms	MEPI, PANCPIN, PI14, TSA2004
Description	Serpin peptidase inhibitor, clade I (pancpin), member 2 (HGNC Symbol)
Entrez gene summary	The gene encodes a member of a family of proteins that acts as inhibitors of serine proteases. These proteins function in the regulation of a variety of physiological processes, including coagulation, fibrinolysis, development, malignancy, and inflammation. Expression of the encoded protein may be downregulated during pancreatic carcinogenesis. Alternative splicing results in multiple transcript variants for this gene. [provided by RefSeq, Jan 2013]
Chromosome	3
Cytoband	q26.1
Chromosome location (bp)	167441789 - 167479004
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000114204 (version 83.38)
Entrez gene	5276
UniProt	O75830 (UniProt - Evidence at protein level)
neXtProt	NX_O75830
Antibodypedia	SERPINI2 antibodies

PROTEIN BROWSER

SERPINI2-001	SERPINI2-002	SERPINI2-003	SERPINI2-004	SERPINI2-006	SERPINI2-201	SERPINI2-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SERPINI2-001 ENSP00000417692 ENST00000461846	O75830 [Direct mapping] Serpin I2 Show all	SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004867 [serine-type endopeptidase inhibitor activity] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0006928 [movement of cell or subcellular component] GO:0010951 [negative regulation of endopeptidase activity] GO:0070062 [extracellular exosome] Show all	405 aa 46.1 kDa	Yes	0
SERPINI2-002 ENSP00000419407 ENST00000471111	O75830 [Direct mapping] Serpin I2 Show all	SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004867 [serine-type endopeptidase inhibitor activity] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0006928 [movement of cell or subcellular component] GO:0010951 [negative regulation of endopeptidase activity] GO:0070062 [extracellular exosome] Show all	405 aa 46.1 kDa	Yes	0
SERPINI2-003 ENSP00000420621 ENST00000476257	O75830 [Direct mapping] Serpin I2 Show all	SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004867 [serine-type endopeptidase inhibitor activity] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0006928 [movement of cell or subcellular component] GO:0010951 [negative regulation of endopeptidase activity] GO:0070062 [extracellular exosome] Show all	405 aa 46.1 kDa	Yes	0
SERPINI2-004 ENSP00000417752 ENST00000466903	C9J7N5 [Direct mapping] Serpin I2 Show all	SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005615 [extracellular space] GO:0010951 [negative regulation of endopeptidase activity] Show all	206 aa 23.7 kDa	Yes	0
SERPINI2-006 ENSP00000419255 ENST00000467583	C9JWE1 [Direct mapping] Serpin I2 Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005615 [extracellular space] GO:0010951 [negative regulation of endopeptidase activity] Show all	157 aa 17.9 kDa	Yes	0
SERPINI2-201 ENSP00000264677 ENST00000264677	O75830 [Direct mapping] Serpin I2 Show all	SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004867 [serine-type endopeptidase inhibitor activity] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0006928 [movement of cell or subcellular component] GO:0010951 [negative regulation of endopeptidase activity] GO:0070062 [extracellular exosome] Show all	405 aa 46.1 kDa	Yes	0
SERPINI2-202 ENSP00000481699 ENST00000616363	A0A0C4DGW9 [Direct mapping] Serpin I2 Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004867 [serine-type endopeptidase inhibitor activity] GO:0005615 [extracellular space] GO:0010951 [negative regulation of endopeptidase activity] GO:0030155 [regulation of cell adhesion] Show all	415 aa 47.4 kDa	Yes	0