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PRKAR2A

CANCER ATLAS

Gene description

 Protein kinase, cAMP-dependent, regulatory, type II, alpha

Protein class

 Plasma proteins, Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA038268
CAB005023

GENE INFORMATION

Gene name

 PRKAR2A (HGNC Symbol)

Synonyms

 PRKAR2

Description

 Protein kinase, cAMP-dependent, regulatory, type II, alpha (HGNC Symbol)

Entrez gene summary

 cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. It may interact with various A-kinase anchoring proteins and determine the subcellular localization of cAMP-dependent protein kinase. This subunit has been shown to regulate protein transport from endosomes to the Golgi apparatus and further to the endoplasmic reticulum (ER). [provided by RefSeq, Jul 2008]

Chromosome

 3

Cytoband

 p21.31

Chromosome location (bp)

 48744597 - 48847846

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000114302 (version 83.38)

Entrez gene

 5576

UniProt

 P13861 (UniProt - Evidence at protein level)

neXtProt

 NX_P13861

Antibodypedia

 PRKAR2A antibodies

PROTEIN BROWSER
PRKAR2A-001
PRKAR2A-002
PRKAR2A-003
PRKAR2A-004
PRKAR2A-005
PRKAR2A-006
PRKAR2A-007

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PRKAR2A-001
ENSP00000265563
ENST00000265563
P13861 [Direct mapping]
cAMP-dependent protein kinase type II-alpha regulatory subunit
A0A024R2W3 [Target identity:100%; Query identity:100%]
Protein kinase, cAMP-dependent, regulatory, type II, alpha, isoform CRA_a
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001932 [regulation of protein phosphorylation]
GO:0003091 [renal water homeostasis]
GO:0004862 [cAMP-dependent protein kinase inhibitor activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0005952 [cAMP-dependent protein kinase complex]
GO:0006112 [energy reserve metabolic process]
GO:0006833 [water transport]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007202 [activation of phospholipase C activity]
GO:0007596 [blood coagulation]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0008603 [cAMP-dependent protein kinase regulator activity]
GO:0016020 [membrane]
GO:0030552 [cAMP binding]
GO:0031588 [nucleotide-activated protein kinase complex]
GO:0031625 [ubiquitin protein ligase binding]
GO:0034199 [activation of protein kinase A activity]
GO:0034236 [protein kinase A catalytic subunit binding]
GO:0035556 [intracellular signal transduction]
GO:0044281 [small molecule metabolic process]
GO:0044853 [plasma membrane raft]
GO:0045087 [innate immune response]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0050796 [regulation of insulin secretion]
GO:0055085 [transmembrane transport]
GO:0070062 [extracellular exosome]
GO:0071377 [cellular response to glucagon stimulus]
GO:0097546 [ciliary base]
GO:2000480 [negative regulation of cAMP-dependent protein kinase activity]
Show all
 404 aa
45.5 kDa 		No 0
PRKAR2A-002
ENSP00000394041
ENST00000454963
P13861 [Direct mapping]
cAMP-dependent protein kinase type II-alpha regulatory subunit
A0A024R2W3 [Target identity:100%; Query identity:100%]
Protein kinase, cAMP-dependent, regulatory, type II, alpha, isoform CRA_a
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001932 [regulation of protein phosphorylation]
GO:0003091 [renal water homeostasis]
GO:0004862 [cAMP-dependent protein kinase inhibitor activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0005952 [cAMP-dependent protein kinase complex]
GO:0006112 [energy reserve metabolic process]
GO:0006833 [water transport]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007202 [activation of phospholipase C activity]
GO:0007596 [blood coagulation]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0008603 [cAMP-dependent protein kinase regulator activity]
GO:0016020 [membrane]
GO:0030552 [cAMP binding]
GO:0031588 [nucleotide-activated protein kinase complex]
GO:0031625 [ubiquitin protein ligase binding]
GO:0034199 [activation of protein kinase A activity]
GO:0034236 [protein kinase A catalytic subunit binding]
GO:0035556 [intracellular signal transduction]
GO:0044281 [small molecule metabolic process]
GO:0044853 [plasma membrane raft]
GO:0045087 [innate immune response]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0050796 [regulation of insulin secretion]
GO:0055085 [transmembrane transport]
GO:0070062 [extracellular exosome]
GO:0071377 [cellular response to glucagon stimulus]
GO:0097546 [ciliary base]
GO:2000480 [negative regulation of cAMP-dependent protein kinase activity]
Show all
 404 aa
45.5 kDa 		No 0
PRKAR2A-003
ENSP00000296446
ENST00000296446
P13861 [Direct mapping]
cAMP-dependent protein kinase type II-alpha regulatory subunit
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001932 [regulation of protein phosphorylation]
GO:0003091 [renal water homeostasis]
GO:0004862 [cAMP-dependent protein kinase inhibitor activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0005952 [cAMP-dependent protein kinase complex]
GO:0006112 [energy reserve metabolic process]
GO:0006833 [water transport]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007202 [activation of phospholipase C activity]
GO:0007596 [blood coagulation]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0008603 [cAMP-dependent protein kinase regulator activity]
GO:0016020 [membrane]
GO:0030552 [cAMP binding]
GO:0031588 [nucleotide-activated protein kinase complex]
GO:0031625 [ubiquitin protein ligase binding]
GO:0034199 [activation of protein kinase A activity]
GO:0034236 [protein kinase A catalytic subunit binding]
GO:0035556 [intracellular signal transduction]
GO:0044281 [small molecule metabolic process]
GO:0044853 [plasma membrane raft]
GO:0045087 [innate immune response]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0050796 [regulation of insulin secretion]
GO:0055085 [transmembrane transport]
GO:0070062 [extracellular exosome]
GO:0071377 [cellular response to glucagon stimulus]
GO:0097546 [ciliary base]
GO:2000480 [negative regulation of cAMP-dependent protein kinase activity]
Show all
 382 aa
43.1 kDa 		No 0
PRKAR2A-004
ENSP00000409239
ENST00000457914
H7C330 [Direct mapping]
cAMP-dependent protein kinase type II-alpha regulatory subunit
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 92 aa
10 kDa 		No 0
PRKAR2A-005
ENSP00000400840
ENST00000437821
H7C1L0 [Direct mapping]
cAMP-dependent protein kinase type II-alpha regulatory subunit
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 200 aa
22.9 kDa 		No 0
PRKAR2A-006
ENSP00000416438
ENST00000438535
H7C4A9 [Direct mapping]
cAMP-dependent protein kinase type II-alpha regulatory subunit
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 99 aa
11.5 kDa 		No 0
PRKAR2A-007
ENSP00000411432
ENST00000419216
C9J830 [Direct mapping]
cAMP-dependent protein kinase type II-alpha regulatory subunit
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 114 aa
12.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.