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Ubiquitin specific peptidase 4 (proto-oncogene) (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is a protease that deubiquitinates target proteins such as ADORA2A and TRIM21. The encoded protein shuttles between the nucleus and cytoplasm and is involved in maintaining operational fidelity in the endoplasmic reticulum. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Enzymes ENZYME proteins Hydrolases Peptidases Cysteine-type peptidases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000244 [spliceosomal tri-snRNP complex assembly] GO:0004197 [cysteine-type endopeptidase activity] GO:0004843 [ubiquitin-specific protease activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005764 [lysosome] GO:0005886 [plasma membrane] GO:0006511 [ubiquitin-dependent protein catabolic process] GO:0016579 [protein deubiquitination] GO:0031397 [negative regulation of protein ubiquitination] GO:0031647 [regulation of protein stability] GO:0031685 [adenosine receptor binding] GO:0034394 [protein localization to cell surface] GO:0036459 [ubiquitinyl hydrolase activity] GO:0042802 [identical protein binding] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0046872 [metal ion binding] GO:0061136 [regulation of proteasomal protein catabolic process]
Enzymes ENZYME proteins Hydrolases Peptidases Cysteine-type peptidases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000244 [spliceosomal tri-snRNP complex assembly] GO:0004197 [cysteine-type endopeptidase activity] GO:0004843 [ubiquitin-specific protease activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005764 [lysosome] GO:0005886 [plasma membrane] GO:0006511 [ubiquitin-dependent protein catabolic process] GO:0016579 [protein deubiquitination] GO:0031397 [negative regulation of protein ubiquitination] GO:0031647 [regulation of protein stability] GO:0031685 [adenosine receptor binding] GO:0034394 [protein localization to cell surface] GO:0036459 [ubiquitinyl hydrolase activity] GO:0042802 [identical protein binding] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0046872 [metal ion binding] GO:0061136 [regulation of proteasomal protein catabolic process]
Enzymes ENZYME proteins Hydrolases Peptidases Cysteine-type peptidases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000244 [spliceosomal tri-snRNP complex assembly] GO:0004197 [cysteine-type endopeptidase activity] GO:0004843 [ubiquitin-specific protease activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005764 [lysosome] GO:0005886 [plasma membrane] GO:0016579 [protein deubiquitination] GO:0031397 [negative regulation of protein ubiquitination] GO:0031647 [regulation of protein stability] GO:0031685 [adenosine receptor binding] GO:0034394 [protein localization to cell surface] GO:0042802 [identical protein binding] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0046872 [metal ion binding] GO:0061136 [regulation of proteasomal protein catabolic process]
