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GNAI2

CANCER ATLAS

Gene description

 Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2

Protein class

 Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Lymphoma

STAINING SUMMARY
HPA007704

GENE INFORMATION

Gene name

 GNAI2 (HGNC Symbol)

Synonyms

 GIP, GNAI2B

Description

 Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is an alpha subunit of guanine nucleotide binding proteins (G proteins). The encoded protein contains the guanine nucleotide binding site and is involved in the hormonal regulation of adenylate cyclase. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]

Chromosome

 3

Cytoband

 p21.31

Chromosome location (bp)

 50226292 - 50259355

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000114353 (version 83.38)

Entrez gene

 2771

UniProt

 P04899 (UniProt - Evidence at protein level)

neXtProt

 NX_P04899

Antibodypedia

 GNAI2 antibodies

PROTEIN BROWSER
GNAI2-001
GNAI2-002
GNAI2-003
GNAI2-009
GNAI2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GNAI2-001
ENSP00000312999
ENST00000313601
P04899 [Direct mapping]
Guanine nucleotide-binding protein G(i) subunit alpha-2
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000186 [activation of MAPKK activity]
GO:0001664 [G-protein coupled receptor binding]
GO:0001973 [adenosine receptor signaling pathway]
GO:0003924 [GTPase activity]
GO:0004871 [signal transducer activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0005834 [heterotrimeric G-protein complex]
GO:0005886 [plasma membrane]
GO:0007049 [cell cycle]
GO:0007165 [signal transduction]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007193 [adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway]
GO:0007194 [negative regulation of adenylate cyclase activity]
GO:0007213 [G-protein coupled acetylcholine receptor signaling pathway]
GO:0007214 [gamma-aminobutyric acid signaling pathway]
GO:0007268 [synaptic transmission]
GO:0007584 [response to nutrient]
GO:0007596 [blood coagulation]
GO:0008152 [metabolic process]
GO:0008283 [cell proliferation]
GO:0008284 [positive regulation of cell proliferation]
GO:0016020 [membrane]
GO:0019001 [guanyl nucleotide binding]
GO:0030168 [platelet activation]
GO:0030496 [midbody]
GO:0031683 [G-protein beta/gamma-subunit complex binding]
GO:0035556 [intracellular signal transduction]
GO:0045121 [membrane raft]
GO:0046872 [metal ion binding]
GO:0050805 [negative regulation of synaptic transmission]
GO:0051301 [cell division]
GO:0051924 [regulation of calcium ion transport]
GO:0070062 [extracellular exosome]
GO:1903561 [extracellular vesicle]
Show all
 355 aa
40.5 kDa 		No 0
GNAI2-002
ENSP00000406369
ENST00000451956
P04899 [Direct mapping]
Guanine nucleotide-binding protein G(i) subunit alpha-2
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001664 [G-protein coupled receptor binding]
GO:0001973 [adenosine receptor signaling pathway]
GO:0003924 [GTPase activity]
GO:0004871 [signal transducer activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005834 [heterotrimeric G-protein complex]
GO:0005886 [plasma membrane]
GO:0007049 [cell cycle]
GO:0007165 [signal transduction]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007193 [adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway]
GO:0007194 [negative regulation of adenylate cyclase activity]
GO:0007214 [gamma-aminobutyric acid signaling pathway]
GO:0007268 [synaptic transmission]
GO:0007584 [response to nutrient]
GO:0007596 [blood coagulation]
GO:0008152 [metabolic process]
GO:0016020 [membrane]
GO:0019001 [guanyl nucleotide binding]
GO:0030168 [platelet activation]
GO:0030496 [midbody]
GO:0031683 [G-protein beta/gamma-subunit complex binding]
GO:0046872 [metal ion binding]
GO:0051301 [cell division]
GO:0070062 [extracellular exosome]
GO:1903561 [extracellular vesicle]
Show all
 318 aa
36.5 kDa 		No 0
GNAI2-003
ENSP00000406871
ENST00000422163
P04899 [Direct mapping]
Guanine nucleotide-binding protein G(i) subunit alpha-2
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001664 [G-protein coupled receptor binding]
GO:0001973 [adenosine receptor signaling pathway]
GO:0003924 [GTPase activity]
GO:0004871 [signal transducer activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005834 [heterotrimeric G-protein complex]
GO:0005886 [plasma membrane]
GO:0007049 [cell cycle]
GO:0007165 [signal transduction]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007193 [adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway]
GO:0007194 [negative regulation of adenylate cyclase activity]
GO:0007214 [gamma-aminobutyric acid signaling pathway]
GO:0007268 [synaptic transmission]
GO:0007584 [response to nutrient]
GO:0007596 [blood coagulation]
GO:0008152 [metabolic process]
GO:0016020 [membrane]
GO:0019001 [guanyl nucleotide binding]
GO:0030168 [platelet activation]
GO:0030496 [midbody]
GO:0031683 [G-protein beta/gamma-subunit complex binding]
GO:0046872 [metal ion binding]
GO:0051301 [cell division]
GO:0070062 [extracellular exosome]
GO:1903561 [extracellular vesicle]
Show all
 339 aa
38.7 kDa 		No 0
GNAI2-009
ENSP00000395736
ENST00000440628
P04899 [Direct mapping]
Guanine nucleotide-binding protein G(i) subunit alpha-2
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001664 [G-protein coupled receptor binding]
GO:0001973 [adenosine receptor signaling pathway]
GO:0003924 [GTPase activity]
GO:0004871 [signal transducer activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005834 [heterotrimeric G-protein complex]
GO:0005886 [plasma membrane]
GO:0007049 [cell cycle]
GO:0007165 [signal transduction]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007193 [adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway]
GO:0007194 [negative regulation of adenylate cyclase activity]
GO:0007214 [gamma-aminobutyric acid signaling pathway]
GO:0007268 [synaptic transmission]
GO:0007584 [response to nutrient]
GO:0007596 [blood coagulation]
GO:0008152 [metabolic process]
GO:0016020 [membrane]
GO:0019001 [guanyl nucleotide binding]
GO:0030168 [platelet activation]
GO:0030496 [midbody]
GO:0031683 [G-protein beta/gamma-subunit complex binding]
GO:0046872 [metal ion binding]
GO:0051301 [cell division]
GO:0070062 [extracellular exosome]
GO:1903561 [extracellular vesicle]
Show all
 303 aa
34.9 kDa 		No 0
GNAI2-201
ENSP00000266027
ENST00000266027
P04899 [Direct mapping]
Guanine nucleotide-binding protein G(i) subunit alpha-2
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001664 [G-protein coupled receptor binding]
GO:0001973 [adenosine receptor signaling pathway]
GO:0003924 [GTPase activity]
GO:0004871 [signal transducer activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005834 [heterotrimeric G-protein complex]
GO:0005886 [plasma membrane]
GO:0007049 [cell cycle]
GO:0007165 [signal transduction]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007193 [adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway]
GO:0007194 [negative regulation of adenylate cyclase activity]
GO:0007214 [gamma-aminobutyric acid signaling pathway]
GO:0007268 [synaptic transmission]
GO:0007584 [response to nutrient]
GO:0007596 [blood coagulation]
GO:0008152 [metabolic process]
GO:0016020 [membrane]
GO:0019001 [guanyl nucleotide binding]
GO:0030168 [platelet activation]
GO:0030496 [midbody]
GO:0031683 [G-protein beta/gamma-subunit complex binding]
GO:0046872 [metal ion binding]
GO:0051301 [cell division]
GO:0070062 [extracellular exosome]
GO:1903561 [extracellular vesicle]
Show all
 303 aa
34.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.