Expression of TFG in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

TRK-fused gene

Protein class

Cancer-related genes, Disease related genes, Predicted intracellular proteins, Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA019473

GENE INFORMATION
Gene name	TFG (HGNC Symbol)
Synonyms	FLJ36137, SPG57, TF6
Description	TRK-fused gene (HGNC Symbol)
Entrez gene summary	There are several documented fusion oncoproteins encoded partially by this gene. This gene also participates in several oncogenic rearrangements resulting in anaplastic lymphoma and mixoid chondrosarcoma, and may play a role in the NF-kappaB pathway. Multiple transcript variants have been found for this gene. [provided by RefSeq, Sep 2010]
Chromosome	3
Cytoband	q12.2
Chromosome location (bp)	100709331 - 100748966
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000114354 (version 83.38)
Entrez gene	10342
UniProt	Q92734 (UniProt - Evidence at protein level)
neXtProt	NX_Q92734
Antibodypedia	TFG antibodies

PROTEIN BROWSER

TFG-001	TFG-002	TFG-003	TFG-004	TFG-006	TFG-007	TFG-008	TFG-201	TFG-202	TFG-203

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TFG-001 ENSP00000240851 ENST00000240851	Q92734 [Direct mapping] Protein TFG Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0004871 [signal transducer activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006888 [ER to Golgi vesicle-mediated transport] GO:0007165 [signal transduction] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0048208 [COPII vesicle coating] GO:0061024 [membrane organization] GO:0070062 [extracellular exosome] Show all	400 aa 43.4 kDa	No	0
TFG-002 ENSP00000397182 ENST00000418917	Q92734 [Direct mapping] Protein TFG Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0004871 [signal transducer activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006888 [ER to Golgi vesicle-mediated transport] GO:0007165 [signal transduction] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0048208 [COPII vesicle coating] GO:0061024 [membrane organization] GO:0070062 [extracellular exosome] Show all	396 aa 43 kDa	No	0
TFG-003 ENSP00000419960 ENST00000490574	Q92734 [Direct mapping] Protein TFG Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0004871 [signal transducer activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006888 [ER to Golgi vesicle-mediated transport] GO:0007165 [signal transduction] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0048208 [COPII vesicle coating] GO:0061024 [membrane organization] GO:0070062 [extracellular exosome] Show all	400 aa 43.4 kDa	No	0
TFG-004 ENSP00000417952 ENST00000476228	Q92734 [Direct mapping] Protein TFG Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0004871 [signal transducer activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006888 [ER to Golgi vesicle-mediated transport] GO:0007165 [signal transduction] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0048208 [COPII vesicle coating] GO:0061024 [membrane organization] GO:0070062 [extracellular exosome] Show all	396 aa 43 kDa	No	0
TFG-006 ENSP00000419559 ENST00000479672	C9JTY3 [Direct mapping] Protein TFG Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	128 aa 14.8 kDa	No	0
TFG-007 ENSP00000420797 ENST00000487505	C9JJP5 [Direct mapping] Protein TFG Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	181 aa 20.4 kDa	No	0
TFG-008 ENSP00000419504 ENST00000463568	C9JUE0 [Direct mapping] Protein TFG Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	157 aa 17.7 kDa	No	0
TFG-201 ENSP00000477562 ENST00000612059	Q05BK6 [Direct mapping] Protein TFG; TFG protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	366 aa 40.7 kDa	No	1
TFG-202 ENSP00000479269 ENST00000615993	Q92734 [Direct mapping] Protein TFG Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0004871 [signal transducer activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006888 [ER to Golgi vesicle-mediated transport] GO:0007165 [signal transduction] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0048208 [COPII vesicle coating] GO:0061024 [membrane organization] GO:0070062 [extracellular exosome] Show all	284 aa 31.3 kDa	No	0
TFG-203 ENSP00000479981 ENST00000620299	Q92734 [Direct mapping] Protein TFG Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0004871 [signal transducer activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006888 [ER to Golgi vesicle-mediated transport] GO:0007165 [signal transduction] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0048208 [COPII vesicle coating] GO:0061024 [membrane organization] GO:0070062 [extracellular exosome] Show all	284 aa 31.3 kDa	No	0