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CBLB

CANCER ATLAS

Gene description

 Cbl proto-oncogene B, E3 ubiquitin protein ligase

Protein class

 Cancer-related genes, Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA018327
HPA019880

GENE INFORMATION

Gene name

 CBLB (HGNC Symbol)

Synonyms

 Cbl-b, RNF56

Description

 Cbl proto-oncogene B, E3 ubiquitin protein ligase (HGNC Symbol)

Entrez gene summary

Chromosome

 3

Cytoband

 q13.11

Chromosome location (bp)

 105655461 - 105869552

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000114423 (version 83.38)

Entrez gene

 868

UniProt

 Q13191 (UniProt - Evidence at protein level)

neXtProt

 NX_Q13191

Antibodypedia

 CBLB antibodies

PROTEIN BROWSER
CBLB-001
CBLB-002
CBLB-003
CBLB-005
CBLB-007
CBLB-008
CBLB-009
CBLB-010

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CBLB-001
ENSP00000264122
ENST00000264122
Q13191 [Direct mapping]
E3 ubiquitin-protein ligase CBL-B
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001784 [phosphotyrosine binding]
GO:0002669 [positive regulation of T cell anergy]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0004871 [signal transducer activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006607 [NLS-bearing protein import into nucleus]
GO:0006955 [immune response]
GO:0007165 [signal transduction]
GO:0007166 [cell surface receptor signaling pathway]
GO:0008270 [zinc ion binding]
GO:0009629 [response to gravity]
GO:0009725 [response to hormone]
GO:0016567 [protein ubiquitination]
GO:0016874 [ligase activity]
GO:0019901 [protein kinase binding]
GO:0035556 [intracellular signal transduction]
GO:0042110 [T cell activation]
GO:0045121 [membrane raft]
GO:0045732 [positive regulation of protein catabolic process]
GO:0046642 [negative regulation of alpha-beta T cell proliferation]
GO:0050860 [negative regulation of T cell receptor signaling pathway]
Show all
 982 aa
109.4 kDa 		No 0
CBLB-002
ENSP00000384816
ENST00000403724
Q13191 [Direct mapping]
E3 ubiquitin-protein ligase CBL-B
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001784 [phosphotyrosine binding]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0004871 [signal transducer activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006607 [NLS-bearing protein import into nucleus]
GO:0007165 [signal transduction]
GO:0007166 [cell surface receptor signaling pathway]
GO:0008270 [zinc ion binding]
GO:0016567 [protein ubiquitination]
GO:0016874 [ligase activity]
Show all
 770 aa
86.6 kDa 		No 0
CBLB-003
ENSP00000384938
ENST00000405772
B5MC15 [Direct mapping]
Cas-Br-M (Murine) ecotropic retroviral transforming sequence b, isoform CRA_a; E3 ubiquitin-protein ligase CBL-B
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001784 [phosphotyrosine binding]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0004871 [signal transducer activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0007166 [cell surface receptor signaling pathway]
GO:0008270 [zinc ion binding]
GO:0016567 [protein ubiquitination]
GO:0023051 [regulation of signaling]
Show all
 810 aa
90.8 kDa 		No 0
CBLB-005
ENSP00000384170
ENST00000407712
E9PHA9 [Direct mapping]
E3 ubiquitin-protein ligase CBL-B
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0016567 [protein ubiquitination]
GO:0023051 [regulation of signaling]
Show all
 197 aa
21.4 kDa 		No 0
CBLB-007
ENSP00000377598
ENST00000394030
Q68CY2 [Direct mapping]
E3 ubiquitin-protein ligase CBL-B; Putative uncharacterized protein DKFZp779A0729
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0016567 [protein ubiquitination]
GO:0023051 [regulation of signaling]
Show all
 321 aa
34.9 kDa 		No 0
CBLB-008
ENSP00000393906
ENST00000443752
C9JU85 [Direct mapping]
E3 ubiquitin-protein ligase CBL-B
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001784 [phosphotyrosine binding]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0004871 [signal transducer activity]
GO:0005634 [nucleus]
GO:0007166 [cell surface receptor signaling pathway]
GO:0016567 [protein ubiquitination]
GO:0023051 [regulation of signaling]
Show all
 139 aa
16 kDa 		No 0
CBLB-009
ENSP00000409750
ENST00000438603
C9JRB3 [Direct mapping]
E3 ubiquitin-protein ligase CBL-B
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001784 [phosphotyrosine binding]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0004871 [signal transducer activity]
GO:0005634 [nucleus]
GO:0007166 [cell surface receptor signaling pathway]
GO:0016567 [protein ubiquitination]
GO:0023051 [regulation of signaling]
Show all
 161 aa
18.4 kDa 		No 0
CBLB-010
ENSP00000400949
ENST00000447441
C9JU85 [Direct mapping]
E3 ubiquitin-protein ligase CBL-B
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001784 [phosphotyrosine binding]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0004871 [signal transducer activity]
GO:0005634 [nucleus]
GO:0007166 [cell surface receptor signaling pathway]
GO:0016567 [protein ubiquitination]
GO:0023051 [regulation of signaling]
Show all
 139 aa
16 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.