Expression of HHLA2 in cancer - Summary

CANCER ATLAS

Gene description

HERV-H LTR-associating 2

Protein class

Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

STAINING SUMMARY

HPA055478

GENE INFORMATION
Gene name	HHLA2 (HGNC Symbol)
Synonyms	B7-H5, B7H7, B7y
Description	HERV-H LTR-associating 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a protein ligand found on the surface of monocytes. The encoded protein is thought to regulate cell-mediated immunity by binding to a receptor on T lymphocytes and inhibiting the proliferation of these cells. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Chromosome	3
Cytoband	q13.13
Chromosome location (bp)	108296490 - 108378285
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000114455 (version 83.38)
Entrez gene	11148
UniProt	Q9UM44 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UM44
Antibodypedia	HHLA2 antibodies

PROTEIN BROWSER

HHLA2-001	HHLA2-002	HHLA2-003	HHLA2-004	HHLA2-005	HHLA2-006	HHLA2-007	HHLA2-008	HHLA2-009	HHLA2-010	HHLA2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
HHLA2-001 ENSP00000350402 ENST00000357759	Q9UM44 [Direct mapping] HERV-H LTR-associating protein 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0001819 [positive regulation of cytokine production] GO:0003674 [molecular_function] GO:0005515 [protein binding] GO:0005575 [cellular_component] GO:0016021 [integral component of membrane] GO:0031295 [T cell costimulation] GO:0042104 [positive regulation of activated T cell proliferation] Show all	414 aa 46.8 kDa	Yes	1
HHLA2-002 ENSP00000418284 ENST00000491820	C9J7D0 [Direct mapping] HERV-H LTR-associating protein 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0005515 [protein binding] GO:0016021 [integral component of membrane] Show all	397 aa 45 kDa	Yes	1
HHLA2-003 ENSP00000418345 ENST00000467562	Q9UM44 [Direct mapping] HERV-H LTR-associating protein 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0001819 [positive regulation of cytokine production] GO:0003674 [molecular_function] GO:0005515 [protein binding] GO:0005575 [cellular_component] GO:0016021 [integral component of membrane] GO:0031295 [T cell costimulation] GO:0042104 [positive regulation of activated T cell proliferation] Show all	350 aa 39.6 kDa	No	1
HHLA2-004 ENSP00000419207 ENST00000467761	Q9UM44 [Direct mapping] HERV-H LTR-associating protein 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0001819 [positive regulation of cytokine production] GO:0003674 [molecular_function] GO:0005515 [protein binding] GO:0005575 [cellular_component] GO:0016021 [integral component of membrane] GO:0031295 [T cell costimulation] GO:0042104 [positive regulation of activated T cell proliferation] Show all	414 aa 46.8 kDa	Yes	1
HHLA2-005 ENSP00000418797 ENST00000482099	H7C523 [Direct mapping] HERV-H LTR-associating protein 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0005515 [protein binding] GO:0016021 [integral component of membrane] Show all	328 aa 37.1 kDa	No	1
HHLA2-006 ENSP00000417856 ENST00000489514	Q9UM44 [Direct mapping] HERV-H LTR-associating protein 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0001819 [positive regulation of cytokine production] GO:0003674 [molecular_function] GO:0005515 [protein binding] GO:0005575 [cellular_component] GO:0016021 [integral component of membrane] GO:0031295 [T cell costimulation] GO:0042104 [positive regulation of activated T cell proliferation] Show all	414 aa 46.8 kDa	Yes	1
HHLA2-007 ENSP00000419911 ENST00000462629	C9JY43 [Direct mapping] HERV-H LTR-associating protein 2 Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all		97 aa 11.2 kDa	Yes	0
HHLA2-008 ENSP00000419940 ENST00000463019	C9JY13 [Direct mapping] HERV-H LTR-associating protein 2 Show all	THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005515 [protein binding] Show all	145 aa 16.5 kDa	Yes	0
HHLA2-009 ENSP00000420622 ENST00000467282	C9JD07 [Direct mapping] HERV-H LTR-associating protein 2 Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] Show all	128 aa 14.8 kDa	No	0
HHLA2-010 ENSP00000418174 ENST00000482430	C9J8J7 [Direct mapping] HERV-H LTR-associating protein 2 Show all	THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005515 [protein binding] Show all	136 aa 15.6 kDa	Yes	0
HHLA2-201 ENSP00000482187 ENST00000619531	Q9UM44 [Direct mapping] HERV-H LTR-associating protein 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0001819 [positive regulation of cytokine production] GO:0003674 [molecular_function] GO:0005515 [protein binding] GO:0005575 [cellular_component] GO:0016021 [integral component of membrane] GO:0031295 [T cell costimulation] GO:0042104 [positive regulation of activated T cell proliferation] Show all	414 aa 46.8 kDa	Yes	1