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Several cases of malignant carcinoids, gliomas and melanomas showed moderate to strong cytoplasmic staining. Renal cancers exhibited moderate to strong cytoplasmic and membranous staining with distinct extracellular positivity. Thyroid cancer along with several malignant lymphomas, hepatocellular carcinomas and endometrial cancers showed moderate cytoplasmic staining. Remaining malignant tissues were weakly stained or negative.
Most of the malignant tissues displayed weak to moderate cytoplasmic positivity with occasional nuclear staining. Several cases of lung, testicular and urothelial cancers were negative.
Most of the malignant cells exhibited moderate cytoplasmic positivity. Several cases of breast, endometrial and renal cancers were strongly stained. A majority of lung and skin cancer were weakly stained or negative.
The protein encoded by this gene is a glycogen branching enzyme that catalyzes the transfer of alpha-1,4-linked glucosyl units from the outer end of a glycogen chain to an alpha-1,6 position on the same or a neighboring glycogen chain. Branching of the chains is essential to increase the solubility of the glycogen molecule and, consequently, in reducing the osmotic pressure within cells. Highest level of this enzyme are found in liver and muscle. Mutations in this gene are associated with glycogen storage disease IV (also known as Andersen's disease). [provided by RefSeq, Jul 2008]
Enzymes ENZYME proteins Transferases Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
