We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
Most of the cancer cells showed moderate to strong cytoplasmic positivity with additional membranous staining in a few cases. Gliomas along with most cases of lymphomas, renal, liver and cervical cancers were weakly stained or negative.
Most cancers displayed moderate to strong cytoplasmic immunoreactivity with a granular pattern.
GENE INFORMATION
Gene name
UMPS
Synonyms
Description
Uridine monophosphate synthetase (HGNC Symbol)
Entrez gene summary
This gene encodes a uridine 5'-monophosphate synthase. The encoded protein is a bifunctional enzyme that catalyzes the final two steps of the de novo pyrimidine biosynthetic pathway. The first reaction is carried out by the N-terminal enzyme orotate phosphoribosyltransferase which converts orotic acid to orotidine-5'-monophosphate. The terminal reaction is carried out by the C-terminal enzyme OMP decarboxylase which converts orotidine-5'-monophosphate to uridine monophosphate. Defects in this gene are the cause of hereditary orotic aciduria. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]
P11172 [Direct mapping] Uridine 5'-monophosphate synthase Orotate phosphoribosyltransferase Orotidine 5'-phosphate decarboxylase A8K5J1 [Target identity:100%; Query identity:100%] Uridine monophosphate synthetase (Orotate phosphoribosyl transferase and orotidine-5'-decarboxylase), isoform CRA_b; Uridine monophosphate synthetase isoform A; cDNA FLJ75687, highly similar to Homo sapiens uridine monophosphate synthetase (orotate phosphoribosyl transferase and orotidine-5'-decarboxylase) (UMPS), mRNA
Show all
Enzymes ENZYME proteins Transferases Lyases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
