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SNX4

CANCER ATLAS

Gene description

 Sorting nexin 4

Protein class

 Plasma proteins, Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA005709

GENE INFORMATION

Gene name

 SNX4 (HGNC Symbol)

Synonyms

 ATG24B

Description

 Sorting nexin 4 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein associated with the long isoform of the leptin receptor and with receptor tyrosine kinases for platelet-derived growth factor, insulin, and epidermal growth factor in cell cultures, but its function is unknown. This protein may form oligomeric complexes with family members. Two transcript variants, one protein coding and the other non-protein coding, have been found for this gene. [provided by RefSeq, Nov 2012]

Chromosome

 3

Cytoband

 q21.2

Chromosome location (bp)

 125446644 - 125520197

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000114520 (version 83.38)

Entrez gene

 8723

UniProt

 O95219 (UniProt - Evidence at protein level)

neXtProt

 NX_O95219

Antibodypedia

 SNX4 antibodies

PROTEIN BROWSER
SNX4-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SNX4-001
ENSP00000251775
ENST00000251775
O95219 [Direct mapping]
Sorting nexin-4
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005154 [epidermal growth factor receptor binding]
GO:0005158 [insulin receptor binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005868 [cytoplasmic dynein complex]
GO:0005886 [plasma membrane]
GO:0006897 [endocytosis]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0016050 [vesicle organization]
GO:0019898 [extrinsic component of membrane]
GO:0031201 [SNARE complex]
GO:0031901 [early endosome membrane]
GO:0032456 [endocytic recycling]
GO:0035091 [phosphatidylinositol binding]
GO:0043234 [protein complex]
GO:1903595 [positive regulation of histamine secretion by mast cell]
GO:1990459 [transferrin receptor binding]
GO:1990460 [leptin receptor binding]
Show all
 450 aa
51.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.