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CISH

CANCER ATLAS

Gene description

 Cytokine inducible SH2-containing protein

Protein class

 Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA040812
CAB034039

GENE INFORMATION

Gene name

 CISH (HGNC Symbol)

Synonyms

 CIS, CIS-1, G18, SOCS

Description

 Cytokine inducible SH2-containing protein (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene contains a SH2 domain and a SOCS box domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by IL2, IL3, GM-CSF and EPO in hematopoietic cells. Proteasome-mediated degradation of this protein has been shown to be involved in the inactivation of the erythropoietin receptor. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]

Chromosome

 3

Cytoband

 p21.2

Chromosome location (bp)

 50606490 - 50611831

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000114737 (version 83.38)

Entrez gene

 1154

UniProt

 Q9NSE2 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NSE2

Antibodypedia

 CISH antibodies

PROTEIN BROWSER
CISH-001
CISH-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CISH-001
ENSP00000294173
ENST00000348721
Q9NSE2 [Direct mapping]
Cytokine-inducible SH2-containing protein
Show all
Predicted intracellular proteins
Show all
GO:0001558 [regulation of cell growth]
GO:0003674 [molecular_function]
GO:0004860 [protein kinase inhibitor activity]
GO:0005515 [protein binding]
GO:0005575 [cellular_component]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006469 [negative regulation of protein kinase activity]
GO:0016567 [protein ubiquitination]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0035556 [intracellular signal transduction]
GO:0046426 [negative regulation of JAK-STAT cascade]
GO:0046627 [negative regulation of insulin receptor signaling pathway]
GO:0060397 [JAK-STAT cascade involved in growth hormone signaling pathway]
GO:1904030 [negative regulation of cyclin-dependent protein kinase activity]
Show all
 258 aa
28.7 kDa 		No 0
CISH-002
ENSP00000409346
ENST00000443053
Q9NSE2 [Direct mapping]
Cytokine-inducible SH2-containing protein
Show all
Predicted intracellular proteins
Show all
GO:0001558 [regulation of cell growth]
GO:0003674 [molecular_function]
GO:0004860 [protein kinase inhibitor activity]
GO:0005515 [protein binding]
GO:0005575 [cellular_component]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006469 [negative regulation of protein kinase activity]
GO:0007205 [protein kinase C-activating G-protein coupled receptor signaling pathway]
GO:0016567 [protein ubiquitination]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0035556 [intracellular signal transduction]
GO:0046426 [negative regulation of JAK-STAT cascade]
GO:0046627 [negative regulation of insulin receptor signaling pathway]
GO:0060397 [JAK-STAT cascade involved in growth hormone signaling pathway]
GO:1904030 [negative regulation of cyclin-dependent protein kinase activity]
Show all
 275 aa
30.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.