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GORASP1

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GENERAL INFORMATION

Gene name

 GORASP1

Gene description

 Golgi reassembly stacking protein 1, 65kDa

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the Golgi apparatus.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Golgi apparatus (supported)

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
HPA056283
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ASSAYS
RNA expression
Human cells
Custom data

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the Golgi apparatus.

Main location

 Golgi apparatus (supported)

 

 

 
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Low
High
G1
S
G2
M
N/A

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Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA056283 A549 Golgi apparatus
HPA056283 HeLa Golgi apparatus
HPA056283 U-2 OS Golgi apparatus

CUSTOM DATA

 

 

 
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Antibody

Cell line

Assay

Description
HPA056283 U-2 OS Image Co-localization with the cis-Golgi marker GM130/GOLGA2 (RRID:AB_398141) after the treatment of U-2 OS cells with brefeldin A (5 ug/ml) for 30 minutes to disrupt the ER to Golgi transport; GOLGA2 localizes together with proteins associated with the Golgi-matrix (PMID: 8557739). GORASP1 is a Golgi-matrix protein, as it co-localizes with the Golgi-matrix marker GOLGA2 after the treatment with BFA.
HPA056283 U-2 OS Image Co-localization with the cis-Golgi marker GM130/GOLGA2 (RRID:AB_398141) for a refined protein localization within the Golgi apparatus in U-2 OS cells. GORASP1 localizes to the Golgi apparatus, but is only detected in the cis-Golgi compartment.

GENE INFORMATION

Gene name

 GORASP1 (HGNC Symbol)

Synonyms

 FLJ23443, GOLPH5, GRASP65, P65

Description

 Golgi reassembly stacking protein 1, 65kDa (HGNC Symbol)

Entrez gene summary

 The Golgi complex plays a key role in the sorting and modification of proteins exported from the endoplasmic reticulum. The protein encoded by this gene is a membrane protein involved in establishing the stacked structure of the Golgi apparatus. It is a caspase-3 substrate, and cleavage of this encoded protein contributes to Golgi fragmentation in apoptosis. This encoded protein can form a complex with the Golgi matrix protein GOLGA2, and this complex binds to the vesicle docking protein p115. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]

Chromosome

 3

Cytoband

 p22.2

Chromosome location (bp)

 39096659 - 39108363

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000114745 (version 83.38)

Entrez gene

 64689

UniProt

 Q9BQQ3 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9BQQ3

Antibodypedia

 GORASP1 antibodies

PROTEIN BROWSER
GORASP1-001
GORASP1-002
GORASP1-004
GORASP1-009
GORASP1-021
GORASP1-022

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GORASP1-001
ENSP00000313869
ENST00000319283
Q9BQQ3 [Direct mapping]
Golgi reassembly-stacking protein 1
A0A024R2U5 [Target identity:100%; Query identity:100%]
Golgi reassembly stacking protein 1, 65kDa, isoform CRA_c
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0000278 [mitotic cell cycle]
GO:0005515 [protein binding]
GO:0005794 [Golgi apparatus]
GO:0006487 [protein N-linked glycosylation]
GO:0006888 [ER to Golgi vesicle-mediated transport]
GO:0007030 [Golgi organization]
GO:0015031 [protein transport]
GO:0018279 [protein N-linked glycosylation via asparagine]
GO:0033116 [endoplasmic reticulum-Golgi intermediate compartment membrane]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0048208 [COPII vesicle coating]
GO:0050774 [negative regulation of dendrite morphogenesis]
GO:0061024 [membrane organization]
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 440 aa
46.5 kDa 		No 0
GORASP1-002
ENSP00000419123
ENST00000479927
B4E1H8 [Direct mapping]
Golgi reassembly-stacking protein 1; cDNA FLJ58222, highly similar to Golgi reassembly-stacking protein 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005794 [Golgi apparatus]
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 345 aa
35.7 kDa 		No 0
GORASP1-004
ENSP00000395709
ENST00000422110
B3KPY8 [Direct mapping]
Golgi reassembly stacking protein 1, 65kDa, isoform CRA_f; Golgi reassembly-stacking protein 1; cDNA FLJ32481 fis, clone SKNMC2001113, moderately similar to Golgi reassembly-stacking protein 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005794 [Golgi apparatus]
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 285 aa
29.2 kDa 		No 0
GORASP1-009
ENSP00000411104
ENST00000441081
C9J9V9 [Direct mapping]
Golgi reassembly-stacking protein 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
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 89 aa
9.8 kDa 		No 0
GORASP1-021
ENSP00000392993
ENST00000437458
C9J0V5 [Direct mapping]
Golgi reassembly-stacking protein 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
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 193 aa
21.6 kDa 		No 0
GORASP1-022
ENSP00000405976
ENST00000416741
C9J5S6 [Direct mapping]
Golgi reassembly-stacking protein 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
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 70 aa
7.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.