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AADAC

GENERAL INFORMATION

Gene name

 AADAC

Gene description

 Arylacetamide deacetylase

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Group enriched (liver, small intestine, duodenum, adrenal gland)
GTEx:Group enriched (adrenal gland, liver)
FANTOM5:Group enriched (small intestine, liver, colon, pancreas)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in several tissues, most adundant in liver, small intestines and adrenal gland.

DATA RELIABILITY

Data reliability
description

 Nuclear staining was seen as off target and disregarded.

Reliability score

 Approved based on 1 antibody.
HPA002911
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Duodenum

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (liver, small intestine, duodenum, adrenal gland)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (adrenal gland, liver)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (small intestine, liver, colon, pancreas)

GENE INFORMATION

Gene name

 AADAC (HGNC Symbol)

Synonyms

 CES5A1, DAC

Description

 Arylacetamide deacetylase (HGNC Symbol)

Entrez gene summary

 Microsomal arylacetamide deacetylase competes against the activity of cytosolic arylamine N-acetyltransferase, which catalyzes one of the initial biotransformation pathways for arylamine and heterocyclic amine carcinogens [provided by RefSeq, Jul 2008]

Chromosome

 3

Cytoband

 q25.1

Chromosome location (bp)

 151814037 - 151828488

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000114771 (version 83.38)

Entrez gene

 13

UniProt

 P22760 (UniProt - Evidence at protein level)

neXtProt

 NX_P22760

Antibodypedia

 AADAC antibodies

PROTEIN BROWSER
AADAC-001
AADAC-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
AADAC-001
ENSP00000232892
ENST00000232892
P22760 [Direct mapping]
Arylacetamide deacetylase
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Enzymes
   ENZYME proteins
   Hydrolases
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   TMHMM predicted membrane proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0004806 [triglyceride lipase activity]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006805 [xenobiotic metabolic process]
GO:0008152 [metabolic process]
GO:0010898 [positive regulation of triglyceride catabolic process]
GO:0016021 [integral component of membrane]
GO:0016298 [lipase activity]
GO:0016787 [hydrolase activity]
GO:0017171 [serine hydrolase activity]
GO:0019213 [deacetylase activity]
GO:0044281 [small molecule metabolic process]
GO:0052689 [carboxylic ester hydrolase activity]
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 399 aa
45.7 kDa 		No 0
AADAC-002
ENSP00000419620
ENST00000488869
C9K0E9 [Direct mapping]
Arylacetamide deacetylase
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   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   TMHMM predicted membrane proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008152 [metabolic process]
GO:0016021 [integral component of membrane]
GO:0016787 [hydrolase activity]
Show all
 204 aa
23.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.