Expression of ARHGEF26 in cancer - Summary

CANCER ATLAS

Gene description

Rho guanine nucleotide exchange factor (GEF) 26

Protein class

Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA017722

GENE INFORMATION
Gene name	ARHGEF26 (HGNC Symbol)
Synonyms	DKFZP434D146, SGEF
Description	Rho guanine nucleotide exchange factor (GEF) 26 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the Rho-guanine nucleotide exchange factor (Rho-GEF) family. These proteins regulate Rho GTPases by catalyzing the exchange of GDP for GTP. The encoded protein specifically activates RhoG and plays a role in the promotion of macropinocytosis. Underexpression of the encoded protein may be a predictive marker of chemoresistant disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011]
Chromosome	3
Cytoband	q25.2
Chromosome location (bp)	154121003 - 154257827
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000114790 (version 83.38)
Entrez gene	26084
UniProt	Q96DR7 (UniProt - Evidence at protein level)
neXtProt	NX_Q96DR7
Antibodypedia	ARHGEF26 antibodies

PROTEIN BROWSER

ARHGEF26-001	ARHGEF26-002	ARHGEF26-003	ARHGEF26-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ARHGEF26-001 ENSP00000348828 ENST00000356448	Q96DR7 [Direct mapping] Rho guanine nucleotide exchange factor 26 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001726 [ruffle] GO:0001886 [endothelial cell morphogenesis] GO:0005089 [Rho guanyl-nucleotide exchange factor activity] GO:0005515 [protein binding] GO:0035023 [regulation of Rho protein signal transduction] GO:0043547 [positive regulation of GTPase activity] GO:0097178 [ruffle assembly] Show all	871 aa 97.3 kDa	No	0
ARHGEF26-002 ENSP00000423418 ENST00000465093	Q96DR7 [Direct mapping] Rho guanine nucleotide exchange factor 26 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001726 [ruffle] GO:0005089 [Rho guanyl-nucleotide exchange factor activity] GO:0005515 [protein binding] GO:0035023 [regulation of Rho protein signal transduction] GO:0043547 [positive regulation of GTPase activity] Show all	871 aa 97.3 kDa	No	0
ARHGEF26-003 ENSP00000424446 ENST00000496710	Q96DR7 [Direct mapping] Rho guanine nucleotide exchange factor 26 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001726 [ruffle] GO:0005089 [Rho guanyl-nucleotide exchange factor activity] GO:0035023 [regulation of Rho protein signal transduction] GO:0043547 [positive regulation of GTPase activity] Show all	791 aa 88.1 kDa	No	0
ARHGEF26-004 ENSP00000423295 ENST00000465817	Q96DR7 [Direct mapping] Rho guanine nucleotide exchange factor 26 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001726 [ruffle] GO:0005089 [Rho guanyl-nucleotide exchange factor activity] GO:0035023 [regulation of Rho protein signal transduction] GO:0043547 [positive regulation of GTPase activity] Show all	446 aa 48.2 kDa	No	0