Expression of VIPR1 in cancer - Summary

CANCER ATLAS

Gene description

Vasoactive intestinal peptide receptor 1

Protein class

G-protein coupled receptors, Predicted membrane proteins, Transporters

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA026777

GENE INFORMATION
Gene name	VIPR1 (HGNC Symbol)
Synonyms	HVR1, RDC1, VPAC1, VPAC1R
Description	Vasoactive intestinal peptide receptor 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a receptor for vasoactive intestinal peptide, a small neuropeptide. Vasoactive intestinal peptide is involved in smooth muscle relaxation, exocrine and endocrine secretion, and water and ion flux in lung and intestinal epithelia. Its actions are effected through integral membrane receptors associated with a guanine nucleotide binding protein which activates adenylate cyclase. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Chromosome	3
Cytoband	p22.1
Chromosome location (bp)	42489299 - 42537573
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000114812 (version 83.38)
Entrez gene	7433
UniProt	P32241 (UniProt - Evidence at protein level)
neXtProt	NX_P32241
Antibodypedia	VIPR1 antibodies

PROTEIN BROWSER

VIPR1-001	VIPR1-002	VIPR1-011	VIPR1-013	VIPR1-201	VIPR1-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
VIPR1-001 ENSP00000327246 ENST00000325123	P32241 [Direct mapping] Vasoactive intestinal polypeptide receptor 1 Show all	Transporters G-protein coupled receptors GPCRs excl olfactory receptors Family 2 (B) receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0004888 [transmembrane signaling receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0004999 [vasoactive intestinal polypeptide receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006936 [muscle contraction] GO:0006955 [immune response] GO:0007166 [cell surface receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007187 [G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger] GO:0007268 [synaptic transmission] GO:0007586 [digestion] GO:0008284 [positive regulation of cell proliferation] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0043235 [receptor complex] Show all	457 aa 51.5 kDa	Yes	7
VIPR1-002 ENSP00000394950 ENST00000433647	P32241 [Direct mapping] Vasoactive intestinal polypeptide receptor 1 A0A024R2N2 [Target identity:100%; Query identity:100%] Vasoactive intestinal peptide receptor 1, isoform CRA_b Show all	Transporters G-protein coupled receptors GPCRs excl olfactory receptors Family 2 (B) receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0004888 [transmembrane signaling receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0004999 [vasoactive intestinal polypeptide receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006936 [muscle contraction] GO:0006955 [immune response] GO:0007166 [cell surface receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007187 [G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger] GO:0007268 [synaptic transmission] GO:0007586 [digestion] GO:0008284 [positive regulation of cell proliferation] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0043235 [receptor complex] Show all	416 aa 47.2 kDa	No	7
VIPR1-011 ENSP00000415013 ENST00000450274	C9JH33 [Direct mapping] Vasoactive intestinal polypeptide receptor 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0004930 [G-protein coupled receptor activity] GO:0004999 [vasoactive intestinal polypeptide receptor activity] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	126 aa 13.8 kDa	No	1
VIPR1-013 ENSP00000403478 ENST00000439731	C9JDT8 [Direct mapping] Vasoactive intestinal polypeptide receptor 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0004930 [G-protein coupled receptor activity] GO:0004999 [vasoactive intestinal polypeptide receptor activity] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	219 aa 23.7 kDa	Yes	1
VIPR1-201 ENSP00000415371 ENST00000438259	P32241 [Direct mapping] Vasoactive intestinal polypeptide receptor 1 Show all	Transporters G-protein coupled receptors GPCRs excl olfactory receptors Family 2 (B) receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Show all	GO:0004888 [transmembrane signaling receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0004999 [vasoactive intestinal polypeptide receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006936 [muscle contraction] GO:0006955 [immune response] GO:0007166 [cell surface receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007187 [G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger] GO:0007268 [synaptic transmission] GO:0007586 [digestion] GO:0008284 [positive regulation of cell proliferation] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0043235 [receptor complex] Show all	247 aa 28.2 kDa	No	4
VIPR1-202 ENSP00000445701 ENST00000543411	P32241 [Direct mapping] Vasoactive intestinal polypeptide receptor 1 Show all	Transporters G-protein coupled receptors GPCRs excl olfactory receptors Family 2 (B) receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0004888 [transmembrane signaling receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0004999 [vasoactive intestinal polypeptide receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006936 [muscle contraction] GO:0006955 [immune response] GO:0007166 [cell surface receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007187 [G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger] GO:0007268 [synaptic transmission] GO:0007586 [digestion] GO:0008284 [positive regulation of cell proliferation] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0043235 [receptor complex] Show all	409 aa 46.3 kDa	No	7