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TNNC1

GENERAL INFORMATION

Gene name

 TNNC1

Gene description

 Troponin C type 1 (slow)

Protein class

 Disease related genes
FDA approved drug targets
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Group enriched (skeletal muscle, heart muscle)
GTEx:Group enriched (skeletal muscle, heart muscle)
FANTOM5:Group enriched (skeletal muscle, heart muscle)

Protein evidence

 Evidence at protein level

Protein expression

 Selective cytoplasmic expression in myocytes.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA056897 , CAB002450
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Heart muscle

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (skeletal muscle, heart muscle)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (skeletal muscle, heart muscle)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (skeletal muscle, heart muscle)

GENE INFORMATION

Gene name

 TNNC1 (HGNC Symbol)

Synonyms

 TNNC

Description

 Troponin C type 1 (slow) (HGNC Symbol)

Entrez gene summary

 Troponin is a central regulatory protein of striated muscle contraction, and together with tropomyosin, is located on the actin filament. Troponin consists of 3 subunits: TnI, which is the inhibitor of actomyosin ATPase; TnT, which contains the binding site for tropomyosin; and TnC, the protein encoded by this gene. The binding of calcium to TnC abolishes the inhibitory action of TnI, thus allowing the interaction of actin with myosin, the hydrolysis of ATP, and the generation of tension. Mutations in this gene are associated with cardiomyopathy dilated type 1Z. [provided by RefSeq, Oct 2008]

Chromosome

 3

Cytoband

 p21.1

Chromosome location (bp)

 52451102 - 52454070

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000114854 (version 83.38)

Entrez gene

 7134

UniProt

 P63316 (UniProt - Evidence at protein level)

neXtProt

 NX_P63316

Antibodypedia

 TNNC1 antibodies

PROTEIN BROWSER
TNNC1-001
TNNC1-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TNNC1-001
ENSP00000232975
ENST00000232975
P63316 [Direct mapping]
Troponin C, slow skeletal and cardiac muscles
Q6FH91 [Target identity:100%; Query identity:100%]
TNNC1 protein; Troponin C type 1 (Slow); Troponin C type 1 (Slow), isoform CRA_a; cDNA, FLJ94344, Homo sapiens troponin C, slow (TNNC1), mRNA
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Predicted intracellular proteins
Plasma proteins
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0002086 [diaphragm contraction]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0005861 [troponin complex]
GO:0006937 [regulation of muscle contraction]
GO:0010038 [response to metal ion]
GO:0014883 [transition between fast and slow fiber]
GO:0015629 [actin cytoskeleton]
GO:0030049 [muscle filament sliding]
GO:0031013 [troponin I binding]
GO:0031014 [troponin T binding]
GO:0032972 [regulation of muscle filament sliding speed]
GO:0042803 [protein homodimerization activity]
GO:0043292 [contractile fiber]
GO:0043462 [regulation of ATPase activity]
GO:0048306 [calcium-dependent protein binding]
GO:0051015 [actin filament binding]
GO:0055010 [ventricular cardiac muscle tissue morphogenesis]
GO:0060048 [cardiac muscle contraction]
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 161 aa
18.4 kDa 		No 0
TNNC1-002
ENSP00000420596
ENST00000496590
C9JDI3 [Direct mapping]
Troponin C, slow skeletal and cardiac muscles
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005509 [calcium ion binding]
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 99 aa
11.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.