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DGUOK

GENERAL INFORMATION

Gene name

 DGUOK

Gene description

 Deoxyguanosine kinase

Protein class

 Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in most tissues at variable levels.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 2 antibodies.
HPA034766 , HPA057246
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 DGUOK (HGNC Symbol)

Synonyms

 dGK

Description

 Deoxyguanosine kinase (HGNC Symbol)

Entrez gene summary

 In mammalian cells, the phosphorylation of purine deoxyribonucleosides is mediated predominantly by two deoxyribonucleoside kinases, cytosolic deoxycytidine kinase and mitochondrial deoxyguanosine kinase. The protein encoded by this gene is responsible for phosphorylation of purine deoxyribonucleosides in the mitochondrial matrix. In addition, this protein phosphorylates several purine deoxyribonucleoside analogs used in the treatment of lymphoproliferative disorders, and this phosphorylation is critical for the effectiveness of the analogs. Alternative splice variants encoding different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 2

Cytoband

 p13.1

Chromosome location (bp)

 73926826 - 73958961

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000114956 (version 83.38)

Entrez gene

 1716

UniProt

 Q16854 (UniProt - Evidence at protein level)

neXtProt

 NX_Q16854

Antibodypedia

 DGUOK antibodies

PROTEIN BROWSER
DGUOK-001
DGUOK-002
DGUOK-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DGUOK-001
ENSP00000264093
ENST00000264093
Q16854 [Direct mapping]
Deoxyguanosine kinase, mitochondrial
E5KSL5 [Target identity:100%; Query identity:100%]
Mitochondrial deoxyguanosine kinase
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Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004138 [deoxyguanosine kinase activity]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0005829 [cytosol]
GO:0006144 [purine nucleobase metabolic process]
GO:0006468 [protein phosphorylation]
GO:0008617 [guanosine metabolic process]
GO:0009157 [deoxyribonucleoside monophosphate biosynthetic process]
GO:0009165 [nucleotide biosynthetic process]
GO:0010977 [negative regulation of neuron projection development]
GO:0019206 [nucleoside kinase activity]
GO:0043101 [purine-containing compound salvage]
GO:0044281 [small molecule metabolic process]
GO:0046070 [dGTP metabolic process]
GO:0046122 [purine deoxyribonucleoside metabolic process]
GO:0055086 [nucleobase-containing small molecule metabolic process]
Show all
 277 aa
32.1 kDa 		No 0
DGUOK-002
ENSP00000306964
ENST00000348222
Q16854 [Direct mapping]
Deoxyguanosine kinase, mitochondrial
E5KSL6 [Target identity:100%; Query identity:100%]
HCG40733, isoform CRA_f; Mitochondrial deoxyguanosine kinase
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Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004138 [deoxyguanosine kinase activity]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0006144 [purine nucleobase metabolic process]
GO:0008617 [guanosine metabolic process]
GO:0009157 [deoxyribonucleoside monophosphate biosynthetic process]
GO:0009165 [nucleotide biosynthetic process]
GO:0019206 [nucleoside kinase activity]
GO:0043101 [purine-containing compound salvage]
GO:0044281 [small molecule metabolic process]
GO:0046122 [purine deoxyribonucleoside metabolic process]
GO:0055086 [nucleobase-containing small molecule metabolic process]
Show all
 189 aa
21.4 kDa 		No 0
DGUOK-201
ENSP00000487122
ENST00000629438
Q16854 [Direct mapping]
Deoxyguanosine kinase, mitochondrial
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004138 [deoxyguanosine kinase activity]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0006144 [purine nucleobase metabolic process]
GO:0008617 [guanosine metabolic process]
GO:0009157 [deoxyribonucleoside monophosphate biosynthetic process]
GO:0009165 [nucleotide biosynthetic process]
GO:0019206 [nucleoside kinase activity]
GO:0043101 [purine-containing compound salvage]
GO:0044281 [small molecule metabolic process]
GO:0046122 [purine deoxyribonucleoside metabolic process]
GO:0055086 [nucleobase-containing small molecule metabolic process]
Show all
 89 aa
9.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.