Cell atlas - TTL - The Human Protein Atlas

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TTL

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoplasm
	Vesicles

Human cell
	Nucleoplasm
	Vesicles

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GENERAL INFORMATION
Gene name	TTL
Gene description	Tubulin tyrosine ligase
Protein class	Cancer-related genes Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleoplasm & vesicles.
RNA cell category	Mixed
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (approved), Vesicles (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA066819
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleoplasm & vesicles.

Main location

Nucleoplasm (approved), Vesicles (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA066819	BJ	Nucleoplasm
	HPA066819	BJ	Vesicles
	HPA066819	SK-MEL-30	Vesicles
	HPA066819	U-2 OS	Nucleoplasm
	HPA066819	U-2 OS	Vesicles

GENE INFORMATION
Gene name	TTL (HGNC Symbol)
Synonyms	MGC46235
Description	Tubulin tyrosine ligase (HGNC Symbol)
Entrez gene summary	TTL is a cytosolic enzyme involved in the posttranslational modification of alpha-tubulin (see MIM 602529). Alpha-tubulin within assembled microtubules is detyrosinated over time at the C terminus. After microtubule disassembly, TTL restores the tyrosine residues and consequently participates in a cycle of tubulin detyrosination and tyrosination (Erck et al., 2003 [PubMed 14571137]).[supplied by OMIM, Mar 2008]
Chromosome	2
Cytoband	q14.1
Chromosome location (bp)	112482154 - 112541739
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000114999 (version 83.38)
Entrez gene	150465
UniProt	Q8NG68 (UniProt - Evidence at protein level)
neXtProt	NX_Q8NG68
Antibodypedia	TTL antibodies

PROTEIN BROWSER

TTL-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TTL-001 ENSP00000233336 ENST00000233336	Q8NG68 [Direct mapping] Tubulin--tyrosine ligase Show all	Enzymes ENZYME proteins Ligase Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000226 [microtubule cytoskeleton organization] GO:0004835 [tubulin-tyrosine ligase activity] GO:0005524 [ATP binding] GO:0006464 [cellular protein modification process] GO:0030516 [regulation of axon extension] Show all	377 aa 43.2 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.