Tissue expression of STEAP3 - Summary - The Human Protein Atlas

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STEAP3

TISSUE

CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	STEAP3
Gene description	STEAP family member 3, metalloreductase
Protein class	Disease related genes Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (parathyroid gland)
GTEx:	Expressed in all
FANTOM5:	Tissue enriched (liver)

Protein evidence

Evidence at protein level

Protein expression

Mainly cytoplasmic expression in most tissues.

DATA RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending retesting.
Reliability score	Uncertain based on 1 antibody. HPA050510
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

N/A

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

N/A

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (parathyroid gland)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (liver)

GENE INFORMATION
Gene name	STEAP3 (HGNC Symbol)
Synonyms	dudlin-2, STMP3, TSAP6
Description	STEAP family member 3, metalloreductase (HGNC Symbol)
Entrez gene summary	This gene encodes a multipass membrane protein that functions as an iron transporter. The encoded protein can reduce both iron (Fe3+) and copper (Cu2+) cations. This protein may mediate downstream responses to p53, including promoting apoptosis. Deficiency in this gene can cause anemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]
Chromosome	2
Cytoband	q14.2
Chromosome location (bp)	119223831 - 119265652
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000115107 (version 83.38)
Entrez gene	55240
UniProt	Q658P3 (UniProt - Evidence at protein level)
neXtProt	NX_Q658P3
Antibodypedia	STEAP3 antibodies

PROTEIN BROWSER

STEAP3-001	STEAP3-002	STEAP3-003	STEAP3-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
STEAP3-001 ENSP00000376822 ENST00000393110	Q658P3 [Direct mapping] Metalloreductase STEAP3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005771 [multivesicular body] GO:0005887 [integral component of plasma membrane] GO:0006879 [cellular iron ion homeostasis] GO:0006915 [apoptotic process] GO:0007049 [cell cycle] GO:0008823 [cupric reductase activity] GO:0009306 [protein secretion] GO:0010008 [endosome membrane] GO:0015677 [copper ion import] GO:0033572 [transferrin transport] GO:0046872 [metal ion binding] GO:0052851 [ferric-chelate reductase (NADPH) activity] GO:0055085 [transmembrane transport] GO:0055114 [oxidation-reduction process] GO:0097461 [ferric iron import into cell] Show all	498 aa 55.7 kDa	No	6
STEAP3-002 ENSP00000376818 ENST00000393106	Q658P3 [Direct mapping] Metalloreductase STEAP3 A0A024RAD7 [Target identity:100%; Query identity:100%] STEAP family member 3, isoform CRA_b Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005771 [multivesicular body] GO:0005887 [integral component of plasma membrane] GO:0006879 [cellular iron ion homeostasis] GO:0006915 [apoptotic process] GO:0007049 [cell cycle] GO:0008823 [cupric reductase activity] GO:0009306 [protein secretion] GO:0010008 [endosome membrane] GO:0015677 [copper ion import] GO:0033572 [transferrin transport] GO:0046872 [metal ion binding] GO:0052851 [ferric-chelate reductase (NADPH) activity] GO:0055085 [transmembrane transport] GO:0055114 [oxidation-reduction process] GO:0097461 [ferric iron import into cell] Show all	488 aa 54.6 kDa	No	6
STEAP3-003 ENSP00000386510 ENST00000409811	B8ZZX6 [Direct mapping] Metalloreductase STEAP3; STEAP family member 3, isoform CRA_c Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005887 [integral component of plasma membrane] GO:0008823 [cupric reductase activity] GO:0015677 [copper ion import] GO:0052851 [ferric-chelate reductase (NADPH) activity] GO:0055114 [oxidation-reduction process] GO:0097461 [ferric iron import into cell] Show all	457 aa 50.6 kDa	No	4
STEAP3-004 ENSP00000376819 ENST00000393107	Q658P3 [Direct mapping] Metalloreductase STEAP3 A0A024RAD7 [Target identity:100%; Query identity:100%] STEAP family member 3, isoform CRA_b Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005771 [multivesicular body] GO:0005887 [integral component of plasma membrane] GO:0006879 [cellular iron ion homeostasis] GO:0006915 [apoptotic process] GO:0007049 [cell cycle] GO:0008823 [cupric reductase activity] GO:0009306 [protein secretion] GO:0010008 [endosome membrane] GO:0015677 [copper ion import] GO:0033572 [transferrin transport] GO:0046872 [metal ion binding] GO:0052851 [ferric-chelate reductase (NADPH) activity] GO:0055085 [transmembrane transport] GO:0055114 [oxidation-reduction process] GO:0097461 [ferric iron import into cell] Show all	488 aa 54.6 kDa	No	6

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The Human Protein Atlas

The Human Protein Atlas project is funded
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