Tissue expression of GPD2 - Summary - The Human Protein Atlas

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GPD2

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TISSUE

CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	GPD2
Gene description	Glycerol-3-phosphate dehydrogenase 2 (mitochondrial)
Protein class	Enzymes Plasma proteins Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression with a granular pattern in all tissues.

DATA RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA008012 , HPA045506
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	GPD2
Synonyms
Description	Glycerol-3-phosphate dehydrogenase 2 (mitochondrial) (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene localizes to the inner mitochondrial membrane and catalyzes the conversion of glycerol-3-phosphate to dihydroxyacetone phosphate, using FAD as a cofactor. Along with GDP1, the encoded protein constitutes the glycerol phosphate shuttle, which reoxidizes NADH formed during glycolysis. Two transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Jan 2010]
Chromosome	2
Cytoband	q24.1
Chromosome location (bp)	156435290 - 156613735
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000115159 (version 83.38)
Entrez gene	2820
UniProt	P43304 (UniProt - Evidence at protein level)
neXtProt	NX_P43304
Antibodypedia	GPD2 antibodies

PROTEIN BROWSER

GPD2-001	GPD2-002	GPD2-003	GPD2-008	GPD2-201	GPD2-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GPD2-001 ENSP00000308610 ENST00000310454	P43304 [Direct mapping] Glycerol-3-phosphate dehydrogenase, mitochondrial Show all	Enzymes ENZYME proteins Oxidoreductases SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004368 [glycerol-3-phosphate dehydrogenase activity] GO:0005509 [calcium ion binding] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0006072 [glycerol-3-phosphate metabolic process] GO:0006094 [gluconeogenesis] GO:0009331 [glycerol-3-phosphate dehydrogenase complex] GO:0016491 [oxidoreductase activity] GO:0019563 [glycerol catabolic process] GO:0035264 [multicellular organism growth] GO:0043010 [camera-type eye development] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] GO:0052591 [sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity] GO:0055114 [oxidation-reduction process] Show all	727 aa 80.9 kDa	Yes	0
GPD2-002 ENSP00000409708 ENST00000438166	P43304 [Direct mapping] Glycerol-3-phosphate dehydrogenase, mitochondrial Show all	Enzymes ENZYME proteins Oxidoreductases SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004368 [glycerol-3-phosphate dehydrogenase activity] GO:0005509 [calcium ion binding] GO:0005743 [mitochondrial inner membrane] GO:0006072 [glycerol-3-phosphate metabolic process] GO:0009331 [glycerol-3-phosphate dehydrogenase complex] GO:0016491 [oxidoreductase activity] GO:0019563 [glycerol catabolic process] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] GO:0052591 [sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity] GO:0055114 [oxidation-reduction process] Show all	727 aa 80.9 kDa	Yes	0
GPD2-003 ENSP00000386425 ENST00000409674	P43304 [Direct mapping] Glycerol-3-phosphate dehydrogenase, mitochondrial Show all	Enzymes ENZYME proteins Oxidoreductases SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004368 [glycerol-3-phosphate dehydrogenase activity] GO:0005509 [calcium ion binding] GO:0005743 [mitochondrial inner membrane] GO:0006072 [glycerol-3-phosphate metabolic process] GO:0009331 [glycerol-3-phosphate dehydrogenase complex] GO:0016491 [oxidoreductase activity] GO:0019563 [glycerol catabolic process] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] GO:0052591 [sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity] GO:0055114 [oxidation-reduction process] Show all	727 aa 80.9 kDa	Yes	0
GPD2-008 ENSP00000412621 ENST00000415049	E7EM56 [Direct mapping] Glycerol-3-phosphate dehydrogenase Show all	TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004368 [glycerol-3-phosphate dehydrogenase activity] GO:0006072 [glycerol-3-phosphate metabolic process] GO:0009331 [glycerol-3-phosphate dehydrogenase complex] GO:0016491 [oxidoreductase activity] GO:0052591 [sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity] GO:0055114 [oxidation-reduction process] Show all	109 aa 11.4 kDa	Yes	0
GPD2-201 ENSP00000386484 ENST00000409125	P43304 [Direct mapping] Glycerol-3-phosphate dehydrogenase, mitochondrial Show all	Enzymes ENZYME proteins Oxidoreductases Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004368 [glycerol-3-phosphate dehydrogenase activity] GO:0005509 [calcium ion binding] GO:0005743 [mitochondrial inner membrane] GO:0006072 [glycerol-3-phosphate metabolic process] GO:0009331 [glycerol-3-phosphate dehydrogenase complex] GO:0016491 [oxidoreductase activity] GO:0019563 [glycerol catabolic process] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] GO:0052591 [sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity] GO:0055114 [oxidation-reduction process] Show all	601 aa 67.5 kDa	No	0
GPD2-202 ENSP00000440892 ENST00000540309	F5GYK7 [Direct mapping] Glycerol-3-phosphate dehydrogenase Show all	SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004368 [glycerol-3-phosphate dehydrogenase activity] GO:0006072 [glycerol-3-phosphate metabolic process] GO:0009331 [glycerol-3-phosphate dehydrogenase complex] GO:0016491 [oxidoreductase activity] GO:0052591 [sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity] GO:0055114 [oxidation-reduction process] Show all	379 aa 41.5 kDa	Yes	0

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The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.