Tissue expression of MPV17 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	MPV17
Gene description	MpV17 mitochondrial inner membrane protein
Protein class	Disease related genes Potential drug targets Predicted intracellular proteins Predicted membrane proteins Transporters
Predicted localization	Intracellular,Membrane
Number of transcripts	11
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	MPV17 (HGNC Symbol)
Synonyms	SYM1
Description	MpV17 mitochondrial inner membrane protein (HGNC Symbol)
Entrez gene summary	This gene encodes a mitochondrial inner membrane protein that is implicated in the metabolism of reactive oxygen species. Mutations in this gene have been associated with the hepatocerebral form of mitochondrial DNA depletion syndrome (MDDS). [provided by RefSeq, Jul 2008]
Chromosome	2
Cytoband	p23.3
Chromosome location (bp)	27309492 - 27325680
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000115204 (version 83.38)
Entrez gene	4358
UniProt	P39210 (UniProt - Evidence at protein level)
neXtProt	NX_P39210
Antibodypedia	MPV17 antibodies

PROTEIN BROWSER

MPV17-001	MPV17-002	MPV17-003	MPV17-004	MPV17-005	MPV17-007	MPV17-010	MPV17-011	MPV17-013	MPV17-015	MPV17-018

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MPV17-001 ENSP00000233545 ENST00000233545	P39210 [Direct mapping] Protein Mpv17 Show all	Transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0000002 [mitochondrial genome maintenance] GO:0003674 [molecular_function] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0005777 [peroxisome] GO:0016021 [integral component of membrane] GO:0032836 [glomerular basement membrane development] GO:0034614 [cellular response to reactive oxygen species] GO:0042592 [homeostatic process] GO:0048839 [inner ear development] GO:2000377 [regulation of reactive oxygen species metabolic process] Show all	176 aa 19.7 kDa	No	4
MPV17-002 ENSP00000369383 ENST00000380044	P39210 [Direct mapping] Protein Mpv17 Show all	Transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000002 [mitochondrial genome maintenance] GO:0003674 [molecular_function] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0005777 [peroxisome] GO:0016021 [integral component of membrane] GO:0032836 [glomerular basement membrane development] GO:0034614 [cellular response to reactive oxygen species] GO:0042592 [homeostatic process] GO:0048839 [inner ear development] GO:2000377 [regulation of reactive oxygen species metabolic process] Show all	176 aa 19.7 kDa	No	4
MPV17-003 ENSP00000349713 ENST00000357186	A8MPV4 [Direct mapping] Protein Mpv17 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	120 aa 13.6 kDa	No	2
MPV17-004 ENSP00000383955 ENST00000402310	B5MC53 [Direct mapping] MpV17 transgene, murine homolog, glomerulosclerosis, isoform CRA_f; Protein Mpv17 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	170 aa 18.6 kDa	No	2
MPV17-005 ENSP00000385671 ENST00000403262	B5MCF8 [Direct mapping] Protein Mpv17 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	171 aa 19 kDa	No	3
MPV17-007 ENSP00000386000 ENST00000402722	B5MC10 [Direct mapping] Protein Mpv17 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		99 aa 10.4 kDa	No	0
MPV17-010 ENSP00000384586 ENST00000405983	E7EX18 [Direct mapping] Protein Mpv17 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	191 aa 21.4 kDa	No	4
MPV17-011 ENSP00000406441 ENST00000430991	H0Y6M5 [Direct mapping] Protein Mpv17 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	121 aa 13.7 kDa	No	1
MPV17-013 ENSP00000405235 ENST00000428910	C9J473 [Direct mapping] Protein Mpv17 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	115 aa 12.7 kDa	No	2
MPV17-015 ENSP00000385175 ENST00000405076	G5E9F5 [Direct mapping] MpV17 transgene, murine homolog, glomerulosclerosis, isoform CRA_d; Protein Mpv17 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	113 aa 13 kDa	No	1
MPV17-018 ENSP00000382006 ENST00000399052	A8MTD3 [Direct mapping] Protein Mpv17 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		110 aa 12.4 kDa	No	0