We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
Most cancer cells displayed moderate to strong granular cytoplasmic positivity with additional membranous positivity in many cases. Lymphomas, gliomas and several cases of melanomas, testicular and hepatocellular carcinomas were negative.
Moderate to strong cytoplasmic and membranous positivity was observed in most urothelial and cervical cancers as well as several lung, breast, skin, pancreatic and endometrial cancers. Remaining cancer were in general weakly stained or negative.
GENE INFORMATION
Gene name
ITGB6
Synonyms
Description
Integrin, beta 6 (HGNC Symbol)
Entrez gene summary
This gene encodes a protein that is a member of the integrin superfamily. Members of this family are adhesion receptors that function in signaling from the extracellular matrix to the cell. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. The encoded protein forms a dimer with an alpha v chain and this heterodimer can bind to ligands like fibronectin and transforming growth factor beta 1. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
