Expression of PPM1G in cancer - Summary

CANCER ATLAS

Gene description

Protein phosphatase, Mg2+/Mn2+ dependent, 1G

Protein class

Enzymes, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA035530	HPA035531

GENE INFORMATION
Gene name	PPM1G (HGNC Symbol)
Synonyms	PP2CG, PP2Cgamma
Description	Protein phosphatase, Mg2+/Mn2+ dependent, 1G (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase is found to be responsible for the dephosphorylation of Pre-mRNA splicing factors, which is important for the formation of functional spliceosome. Studies of a similar gene in mice suggested a role of this phosphatase in regulating cell cycle progression. [provided by RefSeq, Apr 2010]
Chromosome	2
Cytoband	p23.3
Chromosome location (bp)	27381194 - 27409687
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000115241 (version 83.38)
Entrez gene	5496
UniProt	O15355 (UniProt - Evidence at protein level)
neXtProt	NX_O15355
Antibodypedia	PPM1G antibodies

PROTEIN BROWSER

PPM1G-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PPM1G-001 ENSP00000342778 ENST00000344034	O15355 [Direct mapping] Protein phosphatase 1G Q6IAU5 [Target identity:100%; Query identity:100%] PPM1G protein; Protein phosphatase 1G (Formerly 2C), magnesium-dependent, gamma isoform; Putative uncharacterized protein PPM1G Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0004721 [phosphoprotein phosphatase activity] GO:0004722 [protein serine/threonine phosphatase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006470 [protein dephosphorylation] GO:0007050 [cell cycle arrest] GO:0035970 [peptidyl-threonine dephosphorylation] GO:0043169 [cation binding] GO:0046872 [metal ion binding] Show all	546 aa 59.3 kDa	No	0