Fields »
ABOUT
HELP
BLOG
PDE1A

CANCER ATLAS

Gene description

 Phosphodiesterase 1A, calmodulin-dependent

Protein class

 Enzymes, Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA022151

GENE INFORMATION

Gene name

 PDE1A

Synonyms

Description

 Phosphodiesterase 1A, calmodulin-dependent (HGNC Symbol)

Entrez gene summary

 Cyclic nucleotide phosphodiesterases (PDEs) play a role in signal transduction by regulating intracellular cyclic nucleotide concentrations through hydrolysis of cAMP and/or cGMP to their respective nucleoside 5-prime monophosphates. Members of the PDE1 family, such as PDE1A, are Ca(2+)/calmodulin (see CALM1; MIM 114180)-dependent PDEs (CaM-PDEs) that are activated by calmodulin in the presence of Ca(2+) (Michibata et al., 2001 [PubMed 11342109]; Fidock et al., 2002 [PubMed 11747989]).[supplied by OMIM, Oct 2009]

Chromosome

 2

Cytoband

 q32.1

Chromosome location (bp)

 182140036 - 182523192

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000115252 (version 83.38)

Entrez gene

 5136

UniProt

 P54750 (UniProt - Evidence at transcript level)

neXtProt

 NX_P54750

Antibodypedia

 PDE1A antibodies

PROTEIN BROWSER
PDE1A-001
PDE1A-002
PDE1A-003
PDE1A-201
PDE1A-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PDE1A-001
ENSP00000410309
ENST00000435564
P54750 [Direct mapping]
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004114 [3',5'-cyclic-nucleotide phosphodiesterase activity]
GO:0004117 [calmodulin-dependent cyclic-nucleotide phosphodiesterase activity]
GO:0005516 [calmodulin binding]
GO:0005829 [cytosol]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007202 [activation of phospholipase C activity]
GO:0007596 [blood coagulation]
GO:0008081 [phosphoric diester hydrolase activity]
GO:0008152 [metabolic process]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0045087 [innate immune response]
GO:0046872 [metal ion binding]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
Show all
 545 aa
62.3 kDa 		No 0
PDE1A-002
ENSP00000386767
ENST00000409365
P54750 [Direct mapping]
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004114 [3',5'-cyclic-nucleotide phosphodiesterase activity]
GO:0004117 [calmodulin-dependent cyclic-nucleotide phosphodiesterase activity]
GO:0005516 [calmodulin binding]
GO:0005829 [cytosol]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007202 [activation of phospholipase C activity]
GO:0007596 [blood coagulation]
GO:0008081 [phosphoric diester hydrolase activity]
GO:0008152 [metabolic process]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0045087 [innate immune response]
GO:0046872 [metal ion binding]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
Show all
 529 aa
60.6 kDa 		No 0
PDE1A-003
ENSP00000387037
ENST00000410103
P54750 [Direct mapping]
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004114 [3',5'-cyclic-nucleotide phosphodiesterase activity]
GO:0004117 [calmodulin-dependent cyclic-nucleotide phosphodiesterase activity]
GO:0005516 [calmodulin binding]
GO:0005829 [cytosol]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007202 [activation of phospholipase C activity]
GO:0007596 [blood coagulation]
GO:0008081 [phosphoric diester hydrolase activity]
GO:0008152 [metabolic process]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0045087 [innate immune response]
GO:0046872 [metal ion binding]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
Show all
 535 aa
61.3 kDa 		No 0
PDE1A-201
ENSP00000309269
ENST00000351439
P54750 [Direct mapping]
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004114 [3',5'-cyclic-nucleotide phosphodiesterase activity]
GO:0004117 [calmodulin-dependent cyclic-nucleotide phosphodiesterase activity]
GO:0005516 [calmodulin binding]
GO:0005829 [cytosol]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007202 [activation of phospholipase C activity]
GO:0007596 [blood coagulation]
GO:0008081 [phosphoric diester hydrolase activity]
GO:0008152 [metabolic process]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0045087 [innate immune response]
GO:0046872 [metal ion binding]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
Show all
 519 aa
59.6 kDa 		No 0
PDE1A-202
ENSP00000350858
ENST00000358139
P54750 [Direct mapping]
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   THUMBUP predicted membrane proteins
   Phobius predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004114 [3',5'-cyclic-nucleotide phosphodiesterase activity]
GO:0004117 [calmodulin-dependent cyclic-nucleotide phosphodiesterase activity]
GO:0005516 [calmodulin binding]
GO:0005829 [cytosol]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007202 [activation of phospholipase C activity]
GO:0007596 [blood coagulation]
GO:0008081 [phosphoric diester hydrolase activity]
GO:0008152 [metabolic process]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0045087 [innate immune response]
GO:0046872 [metal ion binding]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
Show all
 501 aa
57.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.