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Most cancers showed weak to moderate cytoplasmic positivity.
GENE INFORMATION
Gene name
IFIH1 (HGNC Symbol)
Synonyms
Hlcd, IDDM19, MDA-5, MDA5
Description
Interferon induced with helicase C domain 1 (HGNC Symbol)
Entrez gene summary
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein that is upregulated in response to treatment with beta-interferon and a protein kinase C-activating compound, mezerein. Irreversible reprogramming of melanomas can be achieved by treatment with both these agents; treatment with either agent alone only achieves reversible differentiation. Genetic variation in this gene is associated with diabetes mellitus insulin-dependent type 19. [provided by RefSeq, Jul 2012]
Q9BYX4 [Direct mapping] Interferon-induced helicase C domain-containing protein 1
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Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0003677 [DNA binding] GO:0003725 [double-stranded RNA binding] GO:0003727 [single-stranded RNA binding] GO:0004386 [helicase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005829 [cytosol] GO:0008270 [zinc ion binding] GO:0009597 [detection of virus] GO:0009615 [response to virus] GO:0016032 [viral process] GO:0016787 [hydrolase activity] GO:0016817 [hydrolase activity, acting on acid anhydrides] GO:0016925 [protein sumoylation] GO:0032480 [negative regulation of type I interferon production] GO:0032727 [positive regulation of interferon-alpha production] GO:0032728 [positive regulation of interferon-beta production] GO:0034344 [regulation of type III interferon production] GO:0039528 [cytoplasmic pattern recognition receptor signaling pathway in response to virus] GO:0039530 [MDA-5 signaling pathway] GO:0042981 [regulation of apoptotic process] GO:0043021 [ribonucleoprotein complex binding] GO:0045087 [innate immune response]
Q9BYX4 [Direct mapping] Interferon-induced helicase C domain-containing protein 1
Show all
Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding] GO:0003725 [double-stranded RNA binding] GO:0003727 [single-stranded RNA binding] GO:0004386 [helicase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005829 [cytosol] GO:0008270 [zinc ion binding] GO:0009597 [detection of virus] GO:0009615 [response to virus] GO:0016032 [viral process] GO:0016925 [protein sumoylation] GO:0032480 [negative regulation of type I interferon production] GO:0032727 [positive regulation of interferon-alpha production] GO:0032728 [positive regulation of interferon-beta production] GO:0034344 [regulation of type III interferon production] GO:0039528 [cytoplasmic pattern recognition receptor signaling pathway in response to virus] GO:0039530 [MDA-5 signaling pathway] GO:0042981 [regulation of apoptotic process] GO:0043021 [ribonucleoprotein complex binding] GO:0045087 [innate immune response]
