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NDUFS7

GENERAL INFORMATION

Gene name

 NDUFS7

Gene description

 NADH dehydrogenase (ubiquinone) Fe-S protein 7, 20kDa (NADH-coenzyme Q reductase)

Protein class

 Disease related genes
Enzymes
Plasma proteins
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 7
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (skeletal muscle)
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

DATA RELIABILITY

Reliability score

 Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
N/A
Hippocampus
N/A
N/A
Caudate
N/A
N/A
Cerebellum
N/A
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Appendix
N/A
Tonsil
N/A
Spleen
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Oral mucosa
N/A
N/A
Esophagus
N/A
Stomach
N/A
Duodenum
N/A
Colon
N/A
Rectum
N/A
Kidney & urinary bladder
N/A
Kidney
N/A
Male tissues
N/A
Testis
N/A
Prostate
N/A
Female tissues
N/A
Breast
N/A
Vagina
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Soft tissue
N/A
N/A
Skin
N/A
Skin
N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (skeletal muscle)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 NDUFS7 (HGNC Symbol)

Synonyms

 CI-20, FLJ45860, FLJ46880, PSST

Description

 NADH dehydrogenase (ubiquinone) Fe-S protein 7, 20kDa (NADH-coenzyme Q reductase) (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein that is a subunit of one of the complexes that forms the mitochondrial respiratory chain. This protein is one of over 40 subunits found in complex I, the nicotinamide adenine dinucleotide (NADH):ubiquinone oxidoreductase. This complex functions in the transfer of electrons from NADH to the respiratory chain, and ubiquinone is believed to be the immediate electron acceptor for the enzyme. Mutations in this gene cause Leigh syndrome due to mitochondrial complex I deficiency, a severe neurological disorder that results in bilaterally symmetrical necrotic lesions in subcortical brain regions. [provided by RefSeq, Jul 2008]

Chromosome

 19

Cytoband

 p13.3

Chromosome location (bp)

 1383527 - 1395589

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000115286 (version 83.38)

Entrez gene

 374291

UniProt

 O75251 (UniProt - Evidence at protein level)

neXtProt

 NX_O75251

Antibodypedia

 NDUFS7 antibodies

PROTEIN BROWSER
NDUFS7-001
NDUFS7-002
NDUFS7-005
NDUFS7-016
NDUFS7-020
NDUFS7-201
NDUFS7-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NDUFS7-001
ENSP00000440348
ENST00000546283
O75251 [Direct mapping]
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003954 [NADH dehydrogenase activity]
GO:0005515 [protein binding]
GO:0005747 [mitochondrial respiratory chain complex I]
GO:0005759 [mitochondrial matrix]
GO:0006120 [mitochondrial electron transport, NADH to ubiquinone]
GO:0008137 [NADH dehydrogenase (ubiquinone) activity]
GO:0016655 [oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor]
GO:0022904 [respiratory electron transport chain]
GO:0032981 [mitochondrial respiratory chain complex I assembly]
GO:0044237 [cellular metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
GO:0048038 [quinone binding]
GO:0051536 [iron-sulfur cluster binding]
GO:0051539 [4 iron, 4 sulfur cluster binding]
GO:0055114 [oxidation-reduction process]
Show all
 206 aa
22.2 kDa 		No 0
NDUFS7-002
ENSP00000233627
ENST00000233627
O75251 [Direct mapping]
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial
Q7LD69 [Target identity:100%; Query identity:100%]
NADH-ubiquinone oxidoreductase Fe-S protein 7 variant; NADH:ubiquinone oxidoreductase PSST subunit
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002020 [protease binding]
GO:0003954 [NADH dehydrogenase activity]
GO:0005515 [protein binding]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005747 [mitochondrial respiratory chain complex I]
GO:0005759 [mitochondrial matrix]
GO:0006120 [mitochondrial electron transport, NADH to ubiquinone]
GO:0008137 [NADH dehydrogenase (ubiquinone) activity]
GO:0016655 [oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor]
GO:0022904 [respiratory electron transport chain]
GO:0032981 [mitochondrial respiratory chain complex I assembly]
GO:0043005 [neuron projection]
GO:0043025 [neuronal cell body]
GO:0044237 [cellular metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
GO:0048038 [quinone binding]
GO:0051536 [iron-sulfur cluster binding]
GO:0051539 [4 iron, 4 sulfur cluster binding]
GO:0055114 [oxidation-reduction process]
GO:0097060 [synaptic membrane]
Show all
 213 aa
23.6 kDa 		No 0
NDUFS7-005
ENSP00000443273
ENST00000539480
F5H5N1 [Direct mapping]
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial
Show all
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008137 [NADH dehydrogenase (ubiquinone) activity]
GO:0046872 [metal ion binding]
GO:0048038 [quinone binding]
GO:0051536 [iron-sulfur cluster binding]
GO:0051539 [4 iron, 4 sulfur cluster binding]
GO:0055114 [oxidation-reduction process]
Show all
 182 aa
19.8 kDa 		No 0
NDUFS7-016
ENSP00000406630
ENST00000414651
F5GXJ1 [Direct mapping]
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial
Show all
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008137 [NADH dehydrogenase (ubiquinone) activity]
GO:0046872 [metal ion binding]
GO:0048038 [quinone binding]
GO:0051536 [iron-sulfur cluster binding]
GO:0051539 [4 iron, 4 sulfur cluster binding]
GO:0055114 [oxidation-reduction process]
Show all
 236 aa
25.4 kDa 		No 0
NDUFS7-020
ENSP00000364262
ENST00000313408
O75251 [Direct mapping]
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003954 [NADH dehydrogenase activity]
GO:0005515 [protein binding]
GO:0005747 [mitochondrial respiratory chain complex I]
GO:0005759 [mitochondrial matrix]
GO:0006120 [mitochondrial electron transport, NADH to ubiquinone]
GO:0008137 [NADH dehydrogenase (ubiquinone) activity]
GO:0016655 [oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor]
GO:0022904 [respiratory electron transport chain]
GO:0032981 [mitochondrial respiratory chain complex I assembly]
GO:0044237 [cellular metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
GO:0048038 [quinone binding]
GO:0051536 [iron-sulfur cluster binding]
GO:0051539 [4 iron, 4 sulfur cluster binding]
GO:0055114 [oxidation-reduction process]
Show all
 206 aa
22.2 kDa 		No 0
NDUFS7-201
ENSP00000477895
ENST00000618074
A0A087WTI3 [Direct mapping]
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial
Show all
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0051536 [iron-sulfur cluster binding]
GO:0055114 [oxidation-reduction process]
Show all
 214 aa
23.7 kDa 		No 0
NDUFS7-202
ENSP00000480984
ENST00000620479
A0A087WXF6 [Direct mapping]
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial
Show all
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0051536 [iron-sulfur cluster binding]
GO:0055114 [oxidation-reduction process]
Show all
 214 aa
23.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.