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RTN4

CANCER ATLAS

Gene description

 Reticulon 4

Protein class

 Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Glioma

STAINING SUMMARY
HPA023977
CAB005388

GENE INFORMATION

Gene name

 RTN4 (HGNC Symbol)

Synonyms

 ASY, KIAA0886, NOGO, NSP-CL

Description

 Reticulon 4 (HGNC Symbol)

Entrez gene summary

 This gene belongs to the family of reticulon encoding genes. Reticulons are associated with the endoplasmic reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. The product of this gene is a potent neurite outgrowth inhibitor which may also help block the regeneration of the central nervous system in higher vertebrates. Alternatively spliced transcript variants derived both from differential splicing and differential promoter usage and encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Chromosome

 2

Cytoband

 p16.1

Chromosome location (bp)

 54972187 - 55112621

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000115310 (version 83.38)

Entrez gene

 57142

UniProt

 Q9NQC3 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NQC3

Antibodypedia

 RTN4 antibodies

PROTEIN BROWSER
«
RTN4-001
RTN4-002
RTN4-003
RTN4-004
RTN4-006
RTN4-007
RTN4-008
RTN4-009
RTN4-012
RTN4-013
RTN4-014
RTN4-201
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RTN4-001
ENSP00000337838
ENST00000337526
Q9NQC3 [Direct mapping]
Reticulon-4
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005635 [nuclear envelope]
GO:0005783 [endoplasmic reticulum]
GO:0005886 [plasma membrane]
GO:0006915 [apoptotic process]
GO:0007399 [nervous system development]
GO:0007409 [axonogenesis]
GO:0007413 [axonal fasciculation]
GO:0012505 [endomembrane system]
GO:0021801 [cerebral cortex radial glia guided migration]
GO:0030176 [integral component of endoplasmic reticulum membrane]
GO:0030308 [negative regulation of cell growth]
GO:0030334 [regulation of cell migration]
GO:0030517 [negative regulation of axon extension]
GO:0042981 [regulation of apoptotic process]
GO:0042995 [cell projection]
GO:0044822 [poly(A) RNA binding]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0050770 [regulation of axonogenesis]
GO:0050771 [negative regulation of axonogenesis]
GO:0051960 [regulation of nervous system development]
GO:0060317 [cardiac epithelial to mesenchymal transition]
GO:0070062 [extracellular exosome]
GO:0071786 [endoplasmic reticulum tubular network organization]
GO:0097481 [neuronal postsynaptic density]
GO:2000172 [regulation of branching morphogenesis of a nerve]
Show all
 1192 aa
129.9 kDa 		No 2
RTN4-002
ENSP00000322147
ENST00000317610
Q9NQC3 [Direct mapping]
Reticulon-4
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005635 [nuclear envelope]
GO:0005783 [endoplasmic reticulum]
GO:0005886 [plasma membrane]
GO:0006915 [apoptotic process]
GO:0007409 [axonogenesis]
GO:0007413 [axonal fasciculation]
GO:0012505 [endomembrane system]
GO:0021801 [cerebral cortex radial glia guided migration]
GO:0030176 [integral component of endoplasmic reticulum membrane]
GO:0030308 [negative regulation of cell growth]
GO:0030334 [regulation of cell migration]
GO:0030517 [negative regulation of axon extension]
GO:0042981 [regulation of apoptotic process]
GO:0044822 [poly(A) RNA binding]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0050770 [regulation of axonogenesis]
GO:0050771 [negative regulation of axonogenesis]
GO:0070062 [extracellular exosome]
GO:0071786 [endoplasmic reticulum tubular network organization]
GO:2000172 [regulation of branching morphogenesis of a nerve]
Show all
 373 aa
40.3 kDa 		No 2
RTN4-003
ENSP00000384471
ENST00000405240
Q9NQC3 [Direct mapping]
Reticulon-4
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005635 [nuclear envelope]
GO:0005783 [endoplasmic reticulum]
GO:0005886 [plasma membrane]
GO:0006915 [apoptotic process]
GO:0007409 [axonogenesis]
GO:0007413 [axonal fasciculation]
GO:0012505 [endomembrane system]
GO:0021801 [cerebral cortex radial glia guided migration]
GO:0030176 [integral component of endoplasmic reticulum membrane]
GO:0030308 [negative regulation of cell growth]
GO:0030334 [regulation of cell migration]
GO:0030517 [negative regulation of axon extension]
GO:0042981 [regulation of apoptotic process]
GO:0044822 [poly(A) RNA binding]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0050770 [regulation of axonogenesis]
GO:0050771 [negative regulation of axonogenesis]
GO:0070062 [extracellular exosome]
GO:0071786 [endoplasmic reticulum tubular network organization]
GO:2000172 [regulation of branching morphogenesis of a nerve]
Show all
 986 aa
108.4 kDa 		No 2
RTN4-004
ENSP00000411628
ENST00000427710
C9J685 [Direct mapping]
Reticulon-4
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0007409 [axonogenesis]
GO:0007413 [axonal fasciculation]
GO:0012505 [endomembrane system]
Show all
 91 aa
9.9 kDa 		No 0
RTN4-006
ENSP00000385650
ENST00000404909
Q9NQC3 [Direct mapping]
Reticulon-4
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005635 [nuclear envelope]
GO:0005783 [endoplasmic reticulum]
GO:0005886 [plasma membrane]
GO:0006915 [apoptotic process]
GO:0007409 [axonogenesis]
GO:0007413 [axonal fasciculation]
GO:0012505 [endomembrane system]
GO:0021801 [cerebral cortex radial glia guided migration]
GO:0030176 [integral component of endoplasmic reticulum membrane]
GO:0030308 [negative regulation of cell growth]
GO:0030334 [regulation of cell migration]
GO:0030517 [negative regulation of axon extension]
GO:0042981 [regulation of apoptotic process]
GO:0044822 [poly(A) RNA binding]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0050770 [regulation of axonogenesis]
GO:0050771 [negative regulation of axonogenesis]
GO:0070062 [extracellular exosome]
GO:0071786 [endoplasmic reticulum tubular network organization]
GO:2000172 [regulation of branching morphogenesis of a nerve]
Show all
 986 aa
108.4 kDa 		No 2
RTN4-007
ENSP00000350365
ENST00000357732
Q9NQC3 [Direct mapping]
Reticulon-4
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005635 [nuclear envelope]
GO:0005783 [endoplasmic reticulum]
GO:0005886 [plasma membrane]
GO:0006915 [apoptotic process]
GO:0007409 [axonogenesis]
GO:0007413 [axonal fasciculation]
GO:0012505 [endomembrane system]
GO:0021801 [cerebral cortex radial glia guided migration]
GO:0030176 [integral component of endoplasmic reticulum membrane]
GO:0030308 [negative regulation of cell growth]
GO:0030334 [regulation of cell migration]
GO:0030517 [negative regulation of axon extension]
GO:0042981 [regulation of apoptotic process]
GO:0044822 [poly(A) RNA binding]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0050770 [regulation of axonogenesis]
GO:0050771 [negative regulation of axonogenesis]
GO:0070062 [extracellular exosome]
GO:0071786 [endoplasmic reticulum tubular network organization]
GO:2000172 [regulation of branching morphogenesis of a nerve]
Show all
 392 aa
42.3 kDa 		No 2
RTN4-008
ENSP00000378107
ENST00000394609
Q9NQC3 [Direct mapping]
Reticulon-4
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005635 [nuclear envelope]
GO:0005783 [endoplasmic reticulum]
GO:0005886 [plasma membrane]
GO:0006915 [apoptotic process]
GO:0007409 [axonogenesis]
GO:0007413 [axonal fasciculation]
GO:0012505 [endomembrane system]
GO:0021801 [cerebral cortex radial glia guided migration]
GO:0030176 [integral component of endoplasmic reticulum membrane]
GO:0030308 [negative regulation of cell growth]
GO:0030334 [regulation of cell migration]
GO:0030517 [negative regulation of axon extension]
GO:0042981 [regulation of apoptotic process]
GO:0044822 [poly(A) RNA binding]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0050770 [regulation of axonogenesis]
GO:0050771 [negative regulation of axonogenesis]
GO:0070062 [extracellular exosome]
GO:0071786 [endoplasmic reticulum tubular network organization]
GO:2000172 [regulation of branching morphogenesis of a nerve]
Show all
 199 aa
22.4 kDa 		No 2
RTN4-009
ENSP00000489133
ENST00000486085
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 127 aa
14.1 kDa 		No 0
RTN4-012
ENSP00000397808
ENST00000438462
H7C106 [Direct mapping]
Reticulon
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005789 [endoplasmic reticulum membrane]
GO:0007409 [axonogenesis]
GO:0007413 [axonal fasciculation]
GO:0012505 [endomembrane system]
GO:0016021 [integral component of membrane]
Show all
 203 aa
22.7 kDa 		No 2
RTN4-013
ENSP00000378109
ENST00000394611
Q9NQC3 [Direct mapping]
Reticulon-4
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005635 [nuclear envelope]
GO:0005783 [endoplasmic reticulum]
GO:0005886 [plasma membrane]
GO:0006915 [apoptotic process]
GO:0007409 [axonogenesis]
GO:0007413 [axonal fasciculation]
GO:0012505 [endomembrane system]
GO:0021801 [cerebral cortex radial glia guided migration]
GO:0030176 [integral component of endoplasmic reticulum membrane]
GO:0030308 [negative regulation of cell growth]
GO:0030334 [regulation of cell migration]
GO:0030517 [negative regulation of axon extension]
GO:0042981 [regulation of apoptotic process]
GO:0044822 [poly(A) RNA binding]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0050770 [regulation of axonogenesis]
GO:0050771 [negative regulation of axonogenesis]
GO:0070062 [extracellular exosome]
GO:0071786 [endoplasmic reticulum tubular network organization]
GO:2000172 [regulation of branching morphogenesis of a nerve]
Show all
 986 aa
108.4 kDa 		No 2
RTN4-014
ENSP00000349944
ENST00000357376
Q9NQC3 [Direct mapping]
Reticulon-4
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005635 [nuclear envelope]
GO:0005783 [endoplasmic reticulum]
GO:0005886 [plasma membrane]
GO:0006915 [apoptotic process]
GO:0007409 [axonogenesis]
GO:0007413 [axonal fasciculation]
GO:0012505 [endomembrane system]
GO:0021801 [cerebral cortex radial glia guided migration]
GO:0030176 [integral component of endoplasmic reticulum membrane]
GO:0030308 [negative regulation of cell growth]
GO:0030334 [regulation of cell migration]
GO:0030517 [negative regulation of axon extension]
GO:0042981 [regulation of apoptotic process]
GO:0044822 [poly(A) RNA binding]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0050770 [regulation of axonogenesis]
GO:0050771 [negative regulation of axonogenesis]
GO:0070062 [extracellular exosome]
GO:0071786 [endoplasmic reticulum tubular network organization]
GO:2000172 [regulation of branching morphogenesis of a nerve]
Show all
 986 aa
108.4 kDa 		No 2
RTN4-201
ENSP00000384825
ENST00000402434
F8W914 [Direct mapping]
Reticulon
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005789 [endoplasmic reticulum membrane]
GO:0007409 [axonogenesis]
GO:0007413 [axonal fasciculation]
GO:0012505 [endomembrane system]
GO:0016021 [integral component of membrane]
Show all
 345 aa
37.1 kDa 		No 2

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.