Cell atlas - LOXL3 - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

LOXL3

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION

GENE/PROTEIN

Dictionary

Human cell

Please wait until image is loaded before changing channels

GENERAL INFORMATION
Gene name	LOXL3
Gene description	Lysyl oxidase-like 3
Protein class	Plasma proteins Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	7
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary
RNA cell category	Cell line enhanced (WM-115, U-138 MG)
Protein evidence	Evidence at protein level
Main location	Not available

DATA RELIABILITY
Reliability score	Pending cell analysis.

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (WM-115, U-138 MG) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

GENE INFORMATION
Gene name	LOXL3
Synonyms
Description	Lysyl oxidase-like 3 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family. Alternatively spliced transcript variants of this gene have been reported but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]
Chromosome	2
Cytoband	p13.1
Chromosome location (bp)	74532414 - 74555690
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000115318 (version 83.38)
Entrez gene	84695
UniProt	P58215 (UniProt - Evidence at transcript level)
neXtProt	NX_P58215
Antibodypedia	LOXL3 antibodies

PROTEIN BROWSER

LOXL3-001	LOXL3-002	LOXL3-003	LOXL3-004	LOXL3-005	LOXL3-007	LOXL3-009

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LOXL3-001 ENSP00000264094 ENST00000264094	P58215 [Direct mapping] Lysyl oxidase homolog 3 Show all	THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001837 [epithelial to mesenchymal transition] GO:0004720 [protein-lysine 6-oxidase activity] GO:0005044 [scavenger receptor activity] GO:0005507 [copper ion binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006898 [receptor-mediated endocytosis] GO:0016020 [membrane] GO:0016641 [oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0055114 [oxidation-reduction process] Show all	753 aa 83.2 kDa	Yes	0
LOXL3-002 ENSP00000377512 ENST00000393937	P58215 [Direct mapping] Lysyl oxidase homolog 3 Show all	THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001837 [epithelial to mesenchymal transition] GO:0004720 [protein-lysine 6-oxidase activity] GO:0005044 [scavenger receptor activity] GO:0005507 [copper ion binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006898 [receptor-mediated endocytosis] GO:0016020 [membrane] GO:0016641 [oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0055114 [oxidation-reduction process] Show all	608 aa 67.4 kDa	Yes	0
LOXL3-003 ENSP00000386545 ENST00000409986	B9A025 [Direct mapping] Lysyl oxidase homolog 3 Show all	THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005044 [scavenger receptor activity] GO:0005507 [copper ion binding] GO:0006898 [receptor-mediated endocytosis] GO:0016020 [membrane] GO:0016641 [oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor] GO:0055114 [oxidation-reduction process] Show all	586 aa 64.8 kDa	Yes	0
LOXL3-004 ENSP00000386696 ENST00000409549	E7END4 [Direct mapping] Lysyl oxidase homolog 3 Show all	THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005044 [scavenger receptor activity] GO:0005507 [copper ion binding] GO:0006898 [receptor-mediated endocytosis] GO:0016020 [membrane] GO:0016641 [oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor] GO:0055114 [oxidation-reduction process] Show all	697 aa 77.2 kDa	Yes	0
LOXL3-005 ENSP00000387103 ENST00000409249	B8ZZT6 [Direct mapping] Lysyl oxidase homolog 3 Show all	THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005044 [scavenger receptor activity] GO:0005507 [copper ion binding] GO:0006898 [receptor-mediated endocytosis] GO:0016020 [membrane] GO:0016641 [oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor] GO:0055114 [oxidation-reduction process] Show all	471 aa 51.9 kDa	Yes	0
LOXL3-007 ENSP00000398260 ENST00000413469	C9J5M1 [Direct mapping] Lysyl oxidase homolog 3 Show all	THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005044 [scavenger receptor activity] GO:0006898 [receptor-mediated endocytosis] GO:0016020 [membrane] Show all	303 aa 32.9 kDa	Yes	0
LOXL3-009 ENSP00000404026 ENST00000420535	H7C248 [Direct mapping] Lysyl oxidase homolog 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005044 [scavenger receptor activity] GO:0006898 [receptor-mediated endocytosis] GO:0016020 [membrane] Show all	180 aa 19.5 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.