Expression of GALNT3 in cancer - Summary

CANCER ATLAS

Gene description

Polypeptide N-acetylgalactosaminyltransferase 3

Protein class

Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Pancreatic cancer

STAINING SUMMARY

HPA007613

GENE INFORMATION
Gene name	GALNT3 (HGNC Symbol)
Synonyms	GalNAc-T3, HFTC, HHS
Description	Polypeptide N-acetylgalactosaminyltransferase 3 (HGNC Symbol)
Entrez gene summary	This gene encodes UDP-GalNAc transferase 3, a member of the GalNAc-transferases family. This family transfers an N-acetyl galactosamine to the hydroxyl group of a serine or threonine residue in the first step of O-linked oligosaccharide biosynthesis. Individual GalNAc-transferases have distinct activities and initiation of O-glycosylation is regulated by a repertoire of GalNAc-transferases. The protein encoded by this gene is highly homologous to other family members, however the enzymes have different substrate specificities. [provided by RefSeq, Jul 2008]
Chromosome	2
Cytoband	q24.3
Chromosome location (bp)	165747591 - 165794682
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000115339 (version 83.38)
Entrez gene	2591
UniProt	Q14435 (UniProt - Evidence at protein level)
neXtProt	NX_Q14435
Antibodypedia	GALNT3 antibodies

PROTEIN BROWSER

GALNT3-001	GALNT3-002	GALNT3-003	GALNT3-004	GALNT3-005	GALNT3-006	GALNT3-010

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GALNT3-001 ENSP00000376465 ENST00000392701	Q14435 [Direct mapping] Polypeptide N-acetylgalactosaminyltransferase 3 Show all	Enzymes ENZYME proteins Transferases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0004653 [polypeptide N-acetylgalactosaminyltransferase activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005794 [Golgi apparatus] GO:0005975 [carbohydrate metabolic process] GO:0006493 [protein O-linked glycosylation] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016266 [O-glycan processing] GO:0018242 [protein O-linked glycosylation via serine] GO:0018243 [protein O-linked glycosylation via threonine] GO:0030145 [manganese ion binding] GO:0030246 [carbohydrate binding] GO:0032580 [Golgi cisterna membrane] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0048471 [perinuclear region of cytoplasm] GO:0070062 [extracellular exosome] Show all	633 aa 72.6 kDa	No	0
GALNT3-002 ENSP00000413477 ENST00000414977	C9JXX2 [Direct mapping] Polypeptide N-acetylgalactosaminyltransferase 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	57 aa 7.1 kDa	No	1
GALNT3-003 ENSP00000413694 ENST00000422973	C9JW45 [Direct mapping] Polypeptide N-acetylgalactosaminyltransferase 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		25 aa 3.1 kDa	No	0
GALNT3-004 ENSP00000412643 ENST00000412248	C9J2C3 [Direct mapping] Polypeptide N-acetylgalactosaminyltransferase 3 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	464 aa 53.4 kDa	No	0
GALNT3-005 ENSP00000397112 ENST00000431484	C9J388 [Direct mapping] Polypeptide N-acetylgalactosaminyltransferase 3 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	90 aa 10.8 kDa	No	0
GALNT3-006 ENSP00000399880 ENST00000447156	C9JY57 [Direct mapping] Polypeptide N-acetylgalactosaminyltransferase 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		11 aa 1.3 kDa	No	0
GALNT3-010 ENSP00000386955 ENST00000409882	E7EUL0 [Direct mapping] Polypeptide N-acetylgalactosaminyltransferase 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		371 aa 42.5 kDa	No	0