Cell atlas - MRPL19 - The Human Protein Atlas

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MRPL19

TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Mitochondria

Human cell
	Mitochondria

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GENERAL INFORMATION
Gene name	MRPL19
Gene description	Mitochondrial ribosomal protein L19
Protein class	Plasma proteins Predicted intracellular proteins Ribosomal proteins
Predicted localization	Intracellular
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the mitochondria.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Mitochondria (supported)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA046805
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the mitochondria.

Main location

Mitochondria (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA046805	HEK 293	Mitochondria
	HPA046805	RH-30	Mitochondria
	HPA046805	U-2 OS	Mitochondria

GENE INFORMATION
Gene name	MRPL19 (HGNC Symbol)
Synonyms	KIAA0104, MRP-L15, RLX1, RPML15
Description	Mitochondrial ribosomal protein L19 (HGNC Symbol)
Entrez gene summary	Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. [provided by RefSeq, Jul 2008]
Chromosome	2
Cytoband	p12
Chromosome location (bp)	75646783 - 75690851
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000115364 (version 83.38)
Entrez gene	9801
UniProt	P49406 (UniProt - Evidence at protein level)
neXtProt	NX_P49406
Antibodypedia	MRPL19 antibodies

PROTEIN BROWSER

MRPL19-001	MRPL19-002	MRPL19-004	MRPL19-005	MRPL19-006	MRPL19-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MRPL19-001 ENSP00000377486 ENST00000393909	P49406 [Direct mapping] 39S ribosomal protein L19, mitochondrial Show all	Ribosomal proteins Phobius predicted secreted proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003735 [structural constituent of ribosome] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0005762 [mitochondrial large ribosomal subunit] GO:0005840 [ribosome] GO:0006412 [translation] GO:0006996 [organelle organization] GO:0031965 [nuclear membrane] GO:0032543 [mitochondrial translation] GO:0070124 [mitochondrial translational initiation] GO:0070125 [mitochondrial translational elongation] GO:0070126 [mitochondrial translational termination] Show all	292 aa 33.5 kDa	No	0
MRPL19-002 ENSP00000387284 ENST00000409374	P49406 [Direct mapping] 39S ribosomal protein L19, mitochondrial Show all	Ribosomal proteins Phobius predicted secreted proteins Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003735 [structural constituent of ribosome] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0005743 [mitochondrial inner membrane] GO:0005762 [mitochondrial large ribosomal subunit] GO:0005840 [ribosome] GO:0006412 [translation] GO:0006996 [organelle organization] GO:0031965 [nuclear membrane] GO:0032543 [mitochondrial translation] GO:0070124 [mitochondrial translational initiation] GO:0070125 [mitochondrial translational elongation] GO:0070126 [mitochondrial translational termination] Show all	292 aa 33.5 kDa	No	0
MRPL19-004 ENSP00000474821 ENST00000476622	S4R3W9 [Direct mapping] 39S ribosomal protein L19, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003735 [structural constituent of ribosome] GO:0005622 [intracellular] GO:0005840 [ribosome] GO:0006412 [translation] Show all	143 aa 16.6 kDa	No	0
MRPL19-005 ENSP00000351639 ENST00000358788	A0A0A0MRF4 [Direct mapping] 39S ribosomal protein L19, mitochondrial Show all	Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003735 [structural constituent of ribosome] GO:0005622 [intracellular] GO:0005840 [ribosome] GO:0006412 [translation] Show all	173 aa 19.1 kDa	No	0
MRPL19-006 ENSP00000406267 ENST00000453233	H7C2J0 [Direct mapping] 39S ribosomal protein L19, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003735 [structural constituent of ribosome] GO:0005840 [ribosome] GO:0006412 [translation] Show all	79 aa 9.7 kDa	No	0
MRPL19-007 ENSP00000475090 ENST00000492255	S4R455 [Direct mapping] 39S ribosomal protein L19, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		58 aa 6.5 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.